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Pharmaceutics
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Application of Metal-Based Complexes in Cancer Treatment
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Application of Metal-Based Complexes in Cancer Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4010

Special Issue Editors

Prof. Dr. Lena Ruíz-Azuara

E-Mail Website
Guest Editor
Facultad de Quimica, Universidad Nacional Autónoma de México, Mexico City, Mexico
Interests: metallodrugs; cancer; activity descriptors; tropical neglected diseases
Prof. Dr. Carmen Mejía

E-Mail Website
Guest Editor
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Campus Juriquilla C.P. 76230, Querétaro, Mexico
Interests: cancer; apoptosis; molecular biology; cellular biology; action mechanism

Special Issue Information

Dear Colleagues,

We pleased to invite you to a Special Issue of Pharmaceutics (MDPI) entitled “Application of Metal-Based Complexes in Cancer Treatment”. The aim of this Special Issue is to compile the most recent innovative approaches on metallodrugs that include the design of new molecules with particular properties that may improve cancer treatment. The manuscripts can present studies of new targets, mechanisms of action, molecular and cellular studies, omics advances and differential gene expression, among other mechanisms. High-quality original research articles and reviews are welcome. Any approach to improve cancer treatment with a special type of formulation in order to preserve the activity of metallodrugs for cancer treatment is of interest. Research areas of this SI may include (but are not limited to) the following:

  1. Adult tumors;
  2. Child tumors;
  3. Essential metals;
  4. Non-essential metals.

We look forward to receiving your contributions.

Prof. Dr. Lena Ruíz-Azuara
Prof. Dr. Carmen Mejía
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallodrugs
  • mechanism of action
  • targets
  • pharmaceutical formulation

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Published Papers (3 papers)

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Research

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26 pages, 7005 KiB  
Article
L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity
by Diego Ramírez-Contreras, Sergio Vázquez-Rodríguez, Amalia García-García, Lisset Noriega, Angel Mendoza, Brenda L. Sánchez-Gaytán, Francisco J. Meléndez, María Eugenia Castro, Maura Cárdenas-García and Enrique González-Vergara
Pharmaceutics 2024, 16(6), 747; https://doi.org/10.3390/pharmaceutics16060747 - 31 May 2024
Cited by 2 | Viewed by 908
Abstract
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal [...] Read more.
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2′-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties. Full article
(This article belongs to the Special Issue Application of Metal-Based Complexes in Cancer Treatment)
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11 pages, 772 KiB  
Article
Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100
by Barbara Happl, Marie Brandt, Theresa Balber, Katarína Benčurová, Zeynep Talip, Alexander Voegele, Petra Heffeter, Wolfgang Kandioller, Nicholas P. Van der Meulen, Markus Mitterhauser, Marcus Hacker, Bernhard K. Keppler and Thomas L. Mindt
Pharmaceutics 2023, 15(11), 2626; https://doi.org/10.3390/pharmaceutics15112626 - 15 Nov 2023
Cited by 2 | Viewed by 1524
Abstract
The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer. A radiolabeled version of the compound could present a helpful diagnostic tool. Thus, this study [...] Read more.
The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer. A radiolabeled version of the compound could present a helpful diagnostic tool. Thus, this study investigated the pharmacokinetics of BOLD-100 in more detail to facilitate the stratification of patients for the therapy. The synthesis of [103Ru]BOLD-100, radiolabeled with carrier added (c.a.) ruthenium-103, was established and the product was characterized by HPLC and UV/Vis spectroscopy. In order to compare the radiolabeled and non-radioactive versions of BOLD-100, both complexes were fully evaluated in vitro and in vivo. The cytotoxicity of the compounds was determined in two colon carcinoma cell lines (HCT116 and CT26) and biodistribution studies were performed in Balb/c mice bearing CT26 allografts over a time period of 72 h post injection (p.i.). We report herein preclinical cytotoxicity and pharmacokinetic data for BOLD-100, which were found to be identical to those of its radiolabeled analog [103Ru]BOLD-100. Full article
(This article belongs to the Special Issue Application of Metal-Based Complexes in Cancer Treatment)
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Review

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44 pages, 5021 KiB  
Review
Capped Plasmonic Gold and Silver Nanoparticles with Porphyrins for Potential Use as Anticancer Agents—A Review
by Nthabeleng Hlapisi, Sandile P. Songca and Peter A. Ajibade
Pharmaceutics 2024, 16(10), 1268; https://doi.org/10.3390/pharmaceutics16101268 - 28 Sep 2024
Viewed by 1003
Abstract
Photothermal therapy (PTT) and photodynamic therapy (PDT) are potential cancer treatment methods that are minimally invasive with high specificity for malignant cells. Emerging research has concentrated on the application of metal nanoparticles encapsulated in porphyrin and their derivatives to improve the efficacy of [...] Read more.
Photothermal therapy (PTT) and photodynamic therapy (PDT) are potential cancer treatment methods that are minimally invasive with high specificity for malignant cells. Emerging research has concentrated on the application of metal nanoparticles encapsulated in porphyrin and their derivatives to improve the efficacy of these treatments. Gold and silver nanoparticles have distinct optical properties and biocompatibility, which makes them efficient materials for PDT and PTT. Conjugation of these nanoparticles with porphyrin derivatives increases their light absorption and singlet oxygen generation that create a synergistic effect that increases phototoxicity against cancer cells. Porphyrin encapsulation with gold or silver nanoparticles improves their solubility, stability, and targeted tumor delivery. This paper provides comprehensive review on the design, functionalization, and uses of plasmonic silver and gold nanoparticles in biomedicine and how they can be conjugated with porphyrins for synergistic therapeutic effects. Furthermore, it investigates this dual-modal therapy’s potential advantages and disadvantages and offers perspectives for future prospects. The possibility of developing gold, silver, and porphyrin nanotechnology-enabled biomedicine for combination therapy is also examined. Full article
(This article belongs to the Special Issue Application of Metal-Based Complexes in Cancer Treatment)
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