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Pharmaceutics
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Colloidal Nanocarriers for Dermatological Diseases Therapy
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Colloidal Nanocarriers for Dermatological Diseases Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 8389

Special Issue Editor

Dr. Małgorzata Miastkowska

E-Mail Website
Guest Editor
Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Interests: lipid nanocarriers; hydrogels; wound healing; skin disorders; skin regeneration; drug release kinetics; design of experiments (DOE); molecular dynamics (MD)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Designing novel drug delivery systems that can accurately and safely deliver a drug to a target in a controlled manner with maximum therapeutic effect continues to be the main focus of pharmaceutical and medical research. In recent years, there has been significant development in nanomedicine and nanotechnology for the treatment of skin disorders, including wound healing. In particular, colloidal nanocarriers (nanoemulsions, nanocapsules, lipid nanoparticles, nanoemulgels, etc.) have gained much attention due to their biocompatibility, biodegradability, low toxicity, and ability to encapsulate hydrophobic active substances that are difficult to formulate, thereby increasing their bioavailability. Prolonged and controlled drug release, characteristic of colloidal nanocarriers, allows us to reduce the required amount of active substances and, consequently, eliminate potential side effects. Thanks to these properties, they can be used as effective drug carriers for skin diseases such as local inflammation, bacterial infections, cancer, psoriasis, atopic/contact dermatitis, rosacea and acne.

Dr. Małgorzata Miastkowska
Guest Editor

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Keywords

  • nanoemulsions
  • nanocapsules
  • lipid nanoparticles
  • nanoemulgels
  • skin diseases
  • psoriasis
  • atopic dermatisis
  • skin regeneration
  • controlled drug release

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Published Papers (3 papers)

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Research

26 pages, 3595 KiB  
Article
Novel Transethosomal Gel Containing Miconazole Nitrate; Development, Characterization, and Enhanced Antifungal Activity
by Zara Asghar, Talha Jamshaid, Muhammad Sajid-ur-Rehman, Usama Jamshaid and Heba A. Gad
Pharmaceutics 2023, 15(11), 2537; https://doi.org/10.3390/pharmaceutics15112537 - 27 Oct 2023
Cited by 10 | Viewed by 3259
Abstract
Miconazole nitrate (MCNR) is a BCS class II antifungal drug with poor water solubility. Although numerous attempts have been made to increase its solubility, formulation researchers struggle with this significant issue. Transethosomes are promising novel nanocarriers for improving the solubility and penetration of [...] Read more.
Miconazole nitrate (MCNR) is a BCS class II antifungal drug with poor water solubility. Although numerous attempts have been made to increase its solubility, formulation researchers struggle with this significant issue. Transethosomes are promising novel nanocarriers for improving the solubility and penetration of drugs that are inadequately soluble and permeable. Thus, the objective of this study was to develop MCNR-loaded transethosomal gel in order to enhance skin permeation and antifungal activity. MCNR-loaded transethosomes (MCNR-TEs) were generated using the thin film hydration method and evaluated for their zeta potential, particle size, polydispersity index, and entrapment efficiency (EE%). SEM, FTIR, and DSC analyses were also done to characterize the optimized formulation of MCNR-TEs (MT-8). The optimized formulation of MCNR-TEs was incorporated into a carbopol 934 gel base to form transethosomal gel (MNTG) that was subjected to ex vivo permeation and drug release studies. In vitro antifungal activity was carried out against Candida albicans through the cup plate technique. An in vivo skin irritation test was also performed on Wistar albino rats. MT-8 displayed smooth spherical transethosomal nanoparticles with the highest EE% (89.93 ± 1.32%), lowest particle size (139.3 ± 1.14 nm), polydispersity index (0.188 ± 0.05), and zeta potential (−18.1 ± 0.10 mV). The release profile of MT-8 displayed an initial burst followed by sustained release, and the release data were best fitted with the Korsmeyer-Peppas model. MCNR-loaded transethosomal gel was stable and showed a non-Newtonian flow. It was found that ex vivo drug permeation of MNTG was 48.76%, which was significantly higher than that of MNPG (plain gel) (p ≤ 0.05) following a 24-h permeation study. The prepared MCNR transethosomal gel exhibited increased antifungal activity, and its safety was proven by the results of an in vivo skin irritation test. Therefore, the developed transethosomal gel can be a proficient drug delivery system via a topical route with enhanced antifungal activity and skin permeability. Full article
(This article belongs to the Special Issue Colloidal Nanocarriers for Dermatological Diseases Therapy)
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17 pages, 1559 KiB  
Article
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application
by Michał Dymek, Karolina Olechowska, Katarzyna Hąc-Wydro and Elżbieta Sikora
Pharmaceutics 2023, 15(10), 2485; https://doi.org/10.3390/pharmaceutics15102485 - 18 Oct 2023
Cited by 3 | Viewed by 2840
Abstract
Liposomes are self-assembled spherical systems composed of amphiphilic phospholipids. They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine). Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were obtained as GHK-Cu [...] Read more.
Liposomes are self-assembled spherical systems composed of amphiphilic phospholipids. They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine). Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were obtained as GHK-Cu skin delivery systems using the thin-film hydration method combined with freeze–thaw cycles and the extrusion process. The influence of total lipid content, lipid composition and GHK-Cu concentration on the physicochemical properties of liposomes was studied. The lipid bilayer fluidity and the peptide encapsulation efficiency (EE) were also determined. Moreover, in vitro assays of tyrosinase and elastase inhibition were performed. Stable GHK-Cu-loaded liposome systems of small sizes (approx. 100 nm) were obtained. The bilayer fluidity was higher in the case of cationic liposomes. As the best carriers, 25 mg/cm3 CL and AL hydrated with 0.5 mg/cm3 GHK-Cu were selected with EE of 31.7 ± 0.9% and 20.0 ± 2.8%, respectively. The obtained results confirmed that the liposomes can be used as carriers for biomimetic peptides such as copper-binding peptide and that the GHK-Cu did not significantly affect the tyrosinase activity but led to 48.90 ± 2.50% elastase inhibition, thus reducing the rate of elastin degeneration and supporting the structural integrity of the skin. Full article
(This article belongs to the Special Issue Colloidal Nanocarriers for Dermatological Diseases Therapy)
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17 pages, 4255 KiB  
Article
Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin
by Francesca Della Sala, Assunta Borzacchiello, Chiara Dianzani, Elisabetta Muntoni, Monica Argenziano, Maria Teresa Capucchio, Maria Carmen Valsania, Annalisa Bozza, Sara Garelli, Maria Di Muro, Franco Scorziello and Luigi Battaglia
Pharmaceutics 2023, 15(7), 1962; https://doi.org/10.3390/pharmaceutics15071962 - 16 Jul 2023
Cited by 2 | Viewed by 1691
Abstract
Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum corneum. The efficacy of both phenomena correlates [...] Read more.
Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum corneum. The efficacy of both phenomena correlates with lower nanoparticle size and the increased skin permeation of loaded compounds. The so-called Polysorbate Sorbitan Phase-Inversion Temperature method has, therefore, been optimized in this experimental work, in order to engineer ultrasmall solid-lipid nanoparticles that were then loaded with α-tocopherol, as the anti-age ingredient for cosmetic application. Ultrasmall solid-lipid nanoparticles have been proven to be able to favor the skin absorption of loaded compounds via the aforementioned mechanisms. Full article
(This article belongs to the Special Issue Colloidal Nanocarriers for Dermatological Diseases Therapy)
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