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Pharmaceutics
Special Issues
Nano-Vaccine Systems for Anti-cancer Therapy
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Nano-Vaccine Systems for Anti-cancer Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 5443

Special Issue Editors

Prof. Dr. Chong-Su Cho

E-Mail Website
Guest Editor
Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, Korea
Interests: nanoparticle; nanotechnology; adjuvant; nanovaccinology; polymeric vaccine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. In-Kyu Park

E-Mail Website
Guest Editor
Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju 61469, Korea
Interests: nanoparticles mediated delivery of therapeutic drug and genes; bio-compatible hydrogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Even though chemotherapy is one of the commonly used therapeutic clinical strategies to treat cancer, its effectiveness is limited due to steep dose–response relationships, narrow therapeutic windows, and non-specific organ toxicity. Therefore, we need to develop more effective anti-cancer strategies. Preclinical findings regarding adaptive immune cancer therapy are very impressive, but their translation into clinics has not been very successful so far. One of the major reasons for this is the high complexity of the tumor microenvironment. The immune-suppressive property of tumors makes them inhospitable for anti-tumor immune effector cells, hindering their action against cancer cells. Recent advances in science and technology have led to the development of a variety of delivery systems such as cancer nano-vaccines capable of generating robust antitumor immune responses.  These systems are responsive to variations in pH, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasounds (US). They can even be tailored to be responsive to dual or multiple stimuli. Topics of interest for this Special Issue are natural and synthetic tumor microenvironment-responsive nanoparticles as cancer vaccine delivery systems, anti-tumor immunity-eliciting nanoparticles, and other nano-systems stimulating anti-cancer immune responses.

Prof. Dr. Chong-Su Cho
Prof. Dr. In-Kyu Park
Guest Editors

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Keywords

  • Nano-carriers for anti-cancer vaccine applications 
  • Tumor microenvironment-responsive anti-cancer nano-vaccines 
  • External and internal stimuli-responsive anti-cancer nano-vaccines 
  • Combinational anti-cancer vaccine therapy 
  • Remodeling of tumor microenvironment for anti-cancer nano-vaccines

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Published Papers (1 paper)

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Research

21 pages, 2421 KiB  
Article
Optimization of Liposomes for Antigen Targeting to Splenic CD169+ Macrophages
by Maarten K. Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J. Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm and Joke M.M. den Haan
Pharmaceutics 2020, 12(12), 1138; https://doi.org/10.3390/pharmaceutics12121138 - 25 Nov 2020
Cited by 17 | Viewed by 5020
Abstract
Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture particulate antigens from the blood and transfer these antigens to [...] Read more.
Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture particulate antigens from the blood and transfer these antigens to dendritic cells for the activation of CD8+ T cells. In this study, we incorporated a physiological ligand for CD169, the ganglioside GM3, into liposomes to enhance liposome uptake by CD169+ macrophages. We assessed how variation in the amount of GM3, surface-attached PEG and liposomal size affected the binding to, and uptake by, CD169+ macrophages in vitro and in vivo. As a proof of concept, we prepared GM3-targeted liposomes containing a long synthetic ovalbumin peptide and tested the capacity of these liposomes to induce CD8+ and CD4+ T-cell responses compared to control liposomes or soluble peptide. The data indicate that the delivery of liposomes to splenic CD169+ macrophages can be optimized by the selection of liposomal constituents and liposomal size. Moreover, optimized GM3-mediated liposomal targeting to CD169+ macrophages induces potent immune responses and therefore presents as an interesting delivery strategy for cancer vaccination. Full article
(This article belongs to the Special Issue Nano-Vaccine Systems for Anti-cancer Therapy)
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