Extraction, Characterization, and Biological Activity of Natural Products—2nd Edition

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (1 November 2024) | Viewed by 2009

Special Issue Editors


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Guest Editor
Fraculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia
Interests: bioactive molecules; extraction; subcritical water; supercritical carbon dioxide; natural deep eutectic solvents; green chemistry
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Guest Editor
Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China
Interests: bioactive molecules; extraction; antioxidant; subcritical water
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Special Issue Information

Dear Colleagues,

After the successful and comprehensive Special Issue "Extraction, Characterization, and Biological Activity of Natural Products", it is our great pleasure to invite you to collaborate on a second volume of this Special Issue.

The great importance of bioactive molecules has elicited a high degree of interest among scientists around the world in this topic, and the Special Issue II aims to unite the most important achievements in this field.

The process of extracting and isolating bioactive principles is a crucial step in effectively utilizing their potential. In recent years, significant attention has been paid to modern extraction techniques, primarily those that rely on the use of green solvents, but also processes that seek to minimize waste generation. In this connection, the circular economy is of utmost importance in utilizing bioactive principles. The chemical characterization of extracts, as an important tool in the field of bioactive molecules, is an indispensable element that gives us insight into establishing the connection between chemical composition and certain activities, and represents the starting point for a deeper understanding of the action of bioactive principles. The application of bioactive principles is based on their biological activity, and in vitro and in vivo analyses represent a very important segment that often plays a decisive role in directing the application of plant extracts and isolates. Until recently, the most common application of extracts was in the food industry, pharmacy, medicine, and the cosmetics industry, but recently there are more and more areas in which plant extracts have been applied, including the industry of modern materials, packaging, water purification, and many others.

Special Issue II aims to showcase the latest findings in the isolation, characterization, and application of bioactive principles. Authors are encouraged to submit original papers and review articles.

Dr. Aleksandra Cvetanović Kljakić
Dr. Linlin Yan
Guest Editors

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Keywords

  • natural bioactive compounds
  • bioactivities
  • green extraction technology
  • separation and purification
  • extract application

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Published Papers (1 paper)

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Research

20 pages, 3200 KiB  
Article
Antioxidant, Anti-Inflammation, and Melanogenesis Inhibition of Sang 5 CMU Rice (Oryza sativa) Byproduct for Cosmetic Applications
by Pichchapa Linsaenkart, Warintorn Ruksiriwanich, Anurak Muangsanguan, Sarana Rose Sommano, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Juan M. Castagnini, Romchat Chutoprapat and Korawinwich Boonpisuttinant
Plants 2024, 13(13), 1795; https://doi.org/10.3390/plants13131795 - 28 Jun 2024
Cited by 1 | Viewed by 1310
Abstract
Prolonged exposure to environmental oxidative stress can result in visible signs of skin aging such as wrinkles, hyperpigmentation, and thinning of the skin. Oryza sativa variety Sang 5 CMU, an inbred rice cultivar from northern Thailand, contains phenolic and flavonoid compounds in its [...] Read more.
Prolonged exposure to environmental oxidative stress can result in visible signs of skin aging such as wrinkles, hyperpigmentation, and thinning of the skin. Oryza sativa variety Sang 5 CMU, an inbred rice cultivar from northern Thailand, contains phenolic and flavonoid compounds in its bran and husk portions that are known for their natural antioxidant properties. In this study, we evaluated the cosmetic properties of crude extracts from rice bran and husk of Sang 5 CMU, focusing on antioxidant, anti-inflammatory, anti-melanogenesis, and collagen-regulating properties. Our findings suggest that both extracts possess antioxidant potential against DPPH, ABTS radicals, and metal ions. Additionally, they could downregulate TBARS levels from 125% to 100% of the control, approximately, while increasing the expression of genes related to the NRF2-mediated antioxidant pathway, such as NRF2 and HO-1, in H2O2-induced human fibroblast cells. Notably, rice bran and husk extracts could increase mRNA levels of HO-1 more greatly than the standard L-ascorbic acid, by about 1.29 and 1.07 times, respectively. Furthermore, the crude extracts exhibited anti-inflammatory activity by suppressing nitric oxide production in both mouse macrophage and human fibroblast cells. Specifically, the bran and husk extracts inhibited the gene expression of the inflammatory cytokine IL-6 in LPS-induced inflammation in fibroblasts. Moreover, both extracts demonstrated potential for inhibiting melanin production and intracellular tyrosinase activity in human melanoma cells by decreasing the expression of the transcription factor MITF and the pigmentary genes TYR, TRP-1, and DCT. They also exhibit collagen-stimulating effects by reducing MMP-2 expression in H2O2-induced fibroblasts from 135% to 80% of the control, approximately, and increasing the gene associated with type I collagen production, COL1A1. Overall, the rice bran and husk extracts of Sang 5 CMU showed promise as effective natural ingredients for cosmetic applications. Full article
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