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Polymers
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Functional Polymers Applied to Bioactive Delivery Systems
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Functional Polymers Applied to Bioactive Delivery Systems

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 1948

Special Issue Editors

Prof. Dr. Classius Ferreira Da Silva

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Guest Editor
Departamento de Engenharia Química, Universidade Federal de São Paulo (UNIFESP), Rua São Nicolau, 210, Diadema CEP 09913-030, São Paulo, Brazil
Interests: biopolymers; wound dressings; cosmetic mask sheets; drug delivery systems; packaging systems
Special Issues, Collections and Topics in MDPI journals
Dr. Cristiana Maria Pedroso Yoshida

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Guest Editor
Department of Exact and Earth Science, Universidade Federal de São Paulo (UNIFESP), Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil
Interests: active and biodegradable films; active and intelligent packaging; natural active compounds; delivery of active compounds; use of agro-industrial waste
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Anna Cecilia Venturini

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Guest Editor
Department of Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil
Interests: biopolymers; packaging systems; food science
Prof. Dr. Patrícia Severino

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Guest Editor
Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes (UNIT), Aracaju 49032-490, Brazil
Interests: nanotechnology; biomaterials; drug delivery systems

Special Issue Information

Dear Colleagues,

Polymers are widely used to develop bioactive delivery systems such as particles (nano and microspheres, nano and microcapsules), gels (nano and microgels), micelles, etc. Such delivery systems have been used in medical-pharmaceutical, foods, and cosmetic applications. In medical-pharmaceutical applications, delivery systems may have advantages such as reduced dose frequency, dosage reduction concerning conventional dosage form, specific target, reduction in side effects, etc. In food applications, they can be used as active packaging systems to extend shelf life or improve safety by maintaining the quality of packaged food through delivery; for example, bioactive antioxidant or antimicrobial agents on the surface of the food. In cosmetics, delivery systems can enhance bioactive penetration into the skin layers. However, most conventional polymers do not reach these advantages in bioactive delivery systems. In this sense, it is possible to make chemical modifications to the polymers, making them functional polymers. The functionalization of the polymers confers many properties such as stealth characteristics, environmental stimuli response, reduces toxicity, bioadhesiveness, and provides site-specific delivery (targeting). In this Special Issue, articles will be published on the most recent scientific advances in applying functional polymers in bioactive delivery systems.

Prof. Dr. Classius Ferreira Da Silva
Prof. Dr. Cristiana Maria Pedroso Yoshida
Prof. Dr. Anna Cecilia Venturini
Prof. Dr. Patrícia Severino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cosmetics
  • medical devices
  • drug delivery systems
  • packaging systems
  • intelligent packaging
  • functionalization
  • environmental stimuli response
  • encapsulation
  • nanosystems
  • targeting

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Published Papers (1 paper)

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Research

13 pages, 1789 KiB  
Article
Drug Release Property of Poly 3-Hydroxybutyrate 4-Hydroxybutyrate (P34HB) as Drug-Eluting Coatings on Metal Coronary Stents
by Yihui Jian and Yufang Zhu
Polymers 2022, 14(15), 3018; https://doi.org/10.3390/polym14153018 - 26 Jul 2022
Cited by 3 | Viewed by 1631
Abstract
Drug-eluting stents (DES) have become the main method of interventional therapy for coronary heart disease, because their drug coating can effectively reduce the incidence of restenosis after stent implantation. Biodegradable polymers for coatings are the latest development direction for coating polymers, because they [...] Read more.
Drug-eluting stents (DES) have become the main method of interventional therapy for coronary heart disease, because their drug coating can effectively reduce the incidence of restenosis after stent implantation. Biodegradable polymers for coatings are the latest development direction for coating polymers, because they can be degraded into small molecules in the human body. In this study, the polymer P34HB(P34HB-1:4HB% = 1 mol%, Mw: 225,000; P34HB-10:4HB% = 10 mol%, Mw: 182,000), the fourth generation of biodegradable Polyhydroxy alkanoates (PHAs), was coated on stents to evaluate the drug release properties of the DES. Both P34HB-1 and P34HB-10 coatings showed increased drug release rates, as the polymer concentrations were gradually increased from 8 mg/mL to 28 mg/mL. Both P34HB-1 and P34HB-10 coatings showed increased drug release rates as the drug polymer ratios were gradually changed from 1:10 to 1:2. The drug release rates of the P34HB-1 coatings became slower than P34HB-10, thus showing sustained drug release effects. The drug release rates of the P34HB-1 coatings decreased when Rates of solution flow increased, decreased when Focusing pressures decreased, and decreased when Mandrel moving speeds increased. P34HB-1 coatings prepared with CHCl3/NPA (10:1) mixed solvents had better controlled drug release rates compared to Firebird2®. The drug release rates of P34HB-1 coatings prepared with CHCl3 solutions decreased as the outer layer weights were increased from 0 to 800 μg. When the outer layer weights reached 800 μg, the drug release rates of P34HB-1 coatings were slower than Firebird2®. P34HB-1 coatings prepared with both CHCl3/NPA (10:1) mixed solvents and double layers had more effectively controlled drug release rates than P34HB-1 coatings prepared with only mixed solvents or double layers and these effects were far greater than Firebird2@; thus, P34HB-1 represents a latent polymer for DES. Full article
(This article belongs to the Special Issue Functional Polymers Applied to Bioactive Delivery Systems)
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