Design and Preparation of Pharmaceutical Formulation

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 4183

Special Issue Editor


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Guest Editor
Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan
Interests: drug formulation design; drug formulation preparation; physicochemical characteristics of drug formulations; drug formulation performance; drug formulation development

Special Issue Information

Dear Colleagues,

Many drugs have been developed for the numerous diseases that occur in humans.  However, most drugs typically face two problems—biocompatibility and bio-availability—in clinical cases. To solve such problems and to maximize therapeutic effects, drug formulation development is necessary.

The Special Issue, Design and Preparation of Pharmaceutical Formulation, aims to publish articles in the rapidly developing area of smart drug delivery systems.  The scope of the issue covers topics related to colloidal carriers for drug delivery, such as liposomes, vesicles, emulsions, micelles, nanoparticles, and nano-emulsions, and other smart assembly systems for the improvement in drug delivery. This Special Issue is focused on manufacturing parameters and formulation variables that affect the performance of drug delivery systems. It is our pleasure to invite you submit a new manuscript to this Special Issue. Full papers, communications and reviews are welcome.

Prof. Dr. Tzung-Han Chou
Guest Editor

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Keywords

  • formulation design and preparation
  • physicochemical characteristics of drug formulations
  • manufacturing parameters
  • drug encapsulation and drug release
  • in vitro bioassay

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Published Papers (1 paper)

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Research

24 pages, 7196 KiB  
Article
Polyethylenimine/cGAMP Nanocomplexes for STING-Mediated Cancer Immunotherapy: Formulation and Characterization Using Orthogonal Techniques
by Marija Petrovic, Gerrit Borchard and Olivier Jordan
Processes 2022, 10(5), 882; https://doi.org/10.3390/pr10050882 - 29 Apr 2022
Cited by 3 | Viewed by 2339
Abstract
Cyclic GMP-AMP (cGAMP) has lately been extensively investigated in cancer immunotherapy due its activation of the innate immunity stimulation of interferon genes (STING) pathway within antigen presenting cells (APC) leading to an increase in tumor specific CD8+ T cells. As negatively charged dinucleotides [...] Read more.
Cyclic GMP-AMP (cGAMP) has lately been extensively investigated in cancer immunotherapy due its activation of the innate immunity stimulation of interferon genes (STING) pathway within antigen presenting cells (APC) leading to an increase in tumor specific CD8+ T cells. As negatively charged dinucleotides are prone to enzymatic degradation before being taken up by APC, there is a need for an appropriate carrier. Therefore, polyethylenimine (PEI), a gold standard for oligonucleotide delivery, was selected. Molecular weight, type of PEI and N/P ratio between PEI/cGAMP were investigated in terms of toxicity, efficacy and physicochemical properties of the nanocomplexes (NCs) such as size, zeta potential and shape. Due to lack of nano-medicine regulations and the need for a case-by case assessment, here we examine these parameters by several orthogonal methods, such as dynamic light scattering (DLS), nanoparticle tracking analysis (NTA) and online asymmetric flow field flow fractionation (AF4) connected to DLS. N/P ratio of 2/1 ratio using linear PEI 25 kDa resulted in larger, positively charged particles of elongated shape, which were shown to have the best toxicity/efficacy ratio among different PEIs and ratios tested. Full article
(This article belongs to the Special Issue Design and Preparation of Pharmaceutical Formulation)
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