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Electrochemical Sensors and (Bio)assays for Health Applications
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Electrochemical Sensors and (Bio)assays for Health Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 16681

Special Issue Editors

Prof. Dr. Cristina Delerue-Matos

E-Mail Website
Guest Editor
Instituto Superior de Engenharia do Porto, 4249-015 Porto, Portugal
Interests: chromatographic determinations; electrochemistry; sensors/biosensors; sample preparation; environment and food control; environmental monitoring; contaminant detection; PAHs; pesticides; pharmaceuticals; heavy metals; allergens
Special Issues, Collections and Topics in MDPI journals
Dr. Hendrikus Petrus Antonius Nouws

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal
Interests: electroanalytical methodologies for pharmaceutical, clinical, environmental and food applications
Special Issues, Collections and Topics in MDPI journals
Dr. João G. Pacheco

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal
Interests: molecularly imprinted polymers; electrochemical sensors; inkjet imprinted electrodes; environmental applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of analytical methodologies based on electrochemical (bio)sensing tools is constantly growing but remains a current challenge despite their high sensitivity, simplicity, and the availability of user-friendly portable equipment. Different types of transducers must be tested to develop innovative (bio)assays (e.g., immuno-, geno- and enzymatic sensors; molecular imprinted polymers (MIPs)). The possibility to integrate nanomaterials in sensor construction leads to novel sensing strategies by exploring their unique characteristics. The possibility to use them for in situ single- and multiparametric control increases their demand for a wide range of applications in health care.

This Special Issue will include original research articles and state-of-the-art reviews from academia and industry regarding electrochemical (bio)sensors or (bio)assays for heath applications. Manuscripts with a focus on (bio)sensors and (bio)assays for the early diagnosis of diseases or for patient monitoring and follow-up are welcome. Particular attention will be given to manuscripts that improve the analytical performance and robustness of sensing devices.

Prof. Dr. Cristina Delerue-Matos
Prof. Dr. Hendrikus Nouws
Dr. João Pacheco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemistry
  • (bio)sensors
  • bioassays
  • immunosensors
  • genosensors
  • enzymatic sensors
  • molecularly imprinted polymers
  • disease diagnosis
  • patient follow-up

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Published Papers (4 papers)

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Research

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9 pages, 2136 KiB  
Communication
Fully Integrated 3D-Printed Electronic Device for the On-Field Determination of Antipsychotic Drug Quetiapine
by Katerina Ragazou, Rallis Lougkovois, Vassiliki Katseli and Christos Kokkinos
Sensors 2021, 21(14), 4753; https://doi.org/10.3390/s21144753 - 12 Jul 2021
Cited by 9 | Viewed by 2399
Abstract
In this work, we developed a novel all-3D-printed device for the simple determination of quetiapine fumarate (QF) via voltammetric mode. The device was printed through a one-step process by a dual-extruder 3D printer and it features three thermoplastic electrodes (printed from a carbon [...] Read more.
In this work, we developed a novel all-3D-printed device for the simple determination of quetiapine fumarate (QF) via voltammetric mode. The device was printed through a one-step process by a dual-extruder 3D printer and it features three thermoplastic electrodes (printed from a carbon black-loaded polylactic acid (PLA)) and an electrode holder printed from a non-conductive PLA filament. The integrated 3D-printed device can be printed on-field and it qualifies as a ready-to-use sensor, since it does not require any post-treatment (i.e., modification or activation) before use. The electrochemical parameters, which affect the performance of the sensor in QF determination, were optimized and, under the selected conditions, the quantification of QF was carried out in the concentration range of 5 × 10−7–80 × 10−7 mol × L−1. The limit of detection was 2 × 10−9 mol × L−1, which is lower than that of existing electrochemical QF sensors. The within-device and between-device reproducibility was 4.3% and 6.2% (at 50 × 10−7 mol × L−1 QF level), respectively, demonstrating the satisfactory operational and fabrication reproducibility of the device. Finally, the device was successfully applied for the determination of QF in pharmaceutical tablets and in human urine, justifying its suitability for routine and on-site analysis. Full article
(This article belongs to the Special Issue Electrochemical Sensors and (Bio)assays for Health Applications)
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13 pages, 1547 KiB  
Article
Magnetic Lateral Flow Immunoassay for Small Extracellular Vesicles Quantification: Application to Colorectal Cancer Biomarker Detection
by Amanda Moyano, Esther Serrano-Pertierra, José María Duque, Virginia Ramos, Estefanía Teruel-Barandiarán, María Teresa Fernández-Sánchez, María Salvador, José Carlos Martínez-García, Luis Sánchez, Luis García-Flórez, Montserrat Rivas and María del Carmen Blanco-López
Sensors 2021, 21(11), 3756; https://doi.org/10.3390/s21113756 - 28 May 2021
Cited by 15 | Viewed by 5148
Abstract
Colorectal cancer (CRC) is the third leading cause of cancer death and the fourth most common cancer in the world. Colonoscopy is the most sensitive test used for detection of CRC; however, their procedure is invasive and expensive for population mass screening. Currently, [...] Read more.
Colorectal cancer (CRC) is the third leading cause of cancer death and the fourth most common cancer in the world. Colonoscopy is the most sensitive test used for detection of CRC; however, their procedure is invasive and expensive for population mass screening. Currently, the fecal occult blood test has been widely used as a screening tool for CRC but displays low specificity. The lack of rapid and simple methods for mass screening makes the early diagnosis and therapy monitoring difficult. Extracellular vesicles (EVs) have emerged as a novel source of biomarkers due to their contents in proteins and miRNAs. Their detection would not require invasive techniques and could be considered as a liquid biopsy. Specifically, it has been demonstrated that the amount of CD147 expressed in circulating EVs is significant higher for CRC cell lines than for normal colon fibroblast cell lines. Moreover, CD147-containing EVs have been used as a biomarker to monitor response to therapy in patients with CRC. Therefore, this antigen could be used as a non-invasive biomarker for the detection and monitoring of CRC in combination with a Point-of-Care platform as, for example, Lateral Flow Immunoassays (LFIAs). Here, we propose the development of a quantitative lateral flow immunoassay test based on the use of magnetic nanoparticles as labels coupled to inductive sensor for the non-invasive detection of CRC by CD147-positive EVs. The results obtained for quantification of CD147 antigen embedded in EVs isolated from plasma sample have demonstrated that this device could be used as a Point-of-Care tool for CRC screening or therapy monitoring thanks to its rapid response and easy operation. Full article
(This article belongs to the Special Issue Electrochemical Sensors and (Bio)assays for Health Applications)
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Graphical abstract

12 pages, 3784 KiB  
Communication
Deciphering the Disaggregation Mechanism of Amyloid Beta Aggregate by 4-(2-Hydroxyethyl)-1-Piperazinepropanesulfonic Acid Using Electrochemical Impedance Spectroscopy
by Hien T. Ngoc Le and Sungbo Cho
Sensors 2021, 21(3), 788; https://doi.org/10.3390/s21030788 - 25 Jan 2021
Cited by 8 | Viewed by 3324
Abstract
Aggregation of amyloid-β (aβ) peptides into toxic oligomers, fibrils, and plaques is central in the molecular pathogenesis of Alzheimer’s disease (AD) and is the primary focus of AD diagnostics. Disaggregation or elimination of toxic aβ aggregates in patients is important for delaying the [...] Read more.
Aggregation of amyloid-β (aβ) peptides into toxic oligomers, fibrils, and plaques is central in the molecular pathogenesis of Alzheimer’s disease (AD) and is the primary focus of AD diagnostics. Disaggregation or elimination of toxic aβ aggregates in patients is important for delaying the progression of neurodegenerative disorders in AD. Recently, 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid (EPPS) was introduced as a chemical agent that binds with toxic aβ aggregates and transforms them into monomers to reduce the negative effects of aβ aggregates in the brain. However, the mechanism of aβ disaggregation by EPPS has not yet been completely clarified. In this study, an electrochemical impedimetric immunosensor for aβ diagnostics was developed by immobilizing a specific anti-amyloid-β (aβ) antibody onto a self-assembled monolayer functionalized with a new interdigitated chain-shaped electrode (anti-aβ/SAM/ICE). To investigate the ability of EPPS in recognizing AD by extricating aβ aggregation, commercially available aβ aggregates (aβagg) were used. Electrochemical impedance spectroscopy was used to probe the changes in charge transfer resistance (Rct) of the immunosensor after the specific binding of biosensor with aβagg. The subsequent incubation of the aβagg complex with a specific concentration of EPPS at different time intervals divulged AD progression. The decline in the Rct of the immunosensor started at 10 min of EPPS incubation and continued to decrease gradually from 20 min, indicating that the accumulation of aβagg on the surface of the anti-aβ/SAM/ICE sensor has been extricated. Here, the kinetic disaggregation rate k value of aβagg was found to be 0.038. This innovative study using electrochemical measurement to investigate the mechanism of aβagg disaggregation by EPPS could provide a new perspective in monitoring the disaggregation periods of aβagg from oligomeric to monomeric form, and then support for the prediction and handling AD symptoms at different stages after treatment by a drug, EPPS. Full article
(This article belongs to the Special Issue Electrochemical Sensors and (Bio)assays for Health Applications)
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Review

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26 pages, 3807 KiB  
Review
Paper-Based Enzymatic Electrochemical Sensors for Glucose Determination
by Olaya Amor-Gutiérrez, Estefanía Costa-Rama and M. Teresa Fernández-Abedul
Sensors 2022, 22(16), 6232; https://doi.org/10.3390/s22166232 - 19 Aug 2022
Cited by 18 | Viewed by 4769
Abstract
The general objective of Analytical Chemistry, nowadays, is to obtain best-quality information in the shortest time to contribute to the resolution of real problems. In this regard, electrochemical biosensors are interesting alternatives to conventional methods thanks to their great characteristics, both those intrinsically [...] Read more.
The general objective of Analytical Chemistry, nowadays, is to obtain best-quality information in the shortest time to contribute to the resolution of real problems. In this regard, electrochemical biosensors are interesting alternatives to conventional methods thanks to their great characteristics, both those intrinsically analytical (precision, sensitivity, selectivity, etc.) and those more related to productivity (simplicity, low costs, and fast response, among others). For many years, the scientific community has made continuous progress in improving glucose biosensors, being this analyte the most important in the biosensor market, due to the large amount of people who suffer from diabetes mellitus. The sensitivity of the electrochemical techniques combined with the selectivity of the enzymatic methodologies have positioned electrochemical enzymatic sensors as the first option. This review, focusing on the electrochemical determination of glucose using paper-based analytical devices, shows recent approaches in the use of paper as a substrate for low-cost biosensing. General considerations on the principles of enzymatic detection and the design of paper-based analytical devices are given. Finally, the use of paper in enzymatic electrochemical biosensors for glucose detection, including analytical characteristics of the methodologies reported in relevant articles over the last years, is also covered. Full article
(This article belongs to the Special Issue Electrochemical Sensors and (Bio)assays for Health Applications)
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