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Integration and Application of Microfluidic Sensors
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Integration and Application of Microfluidic Sensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 2487

Special Issue Editors

Dr. Zhen Cao

E-Mail Website
Guest Editor
College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China
Interests: wearable electronics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Weipeng Xuan

E-Mail Website
Guest Editor
Ministry of Education Key Laboratory of RF Circuits and Systems, College of Electronics & Information, Hangzhou Dianzi University, Hangzhou 310000, China
Interests: microdevices based on piezoelectric devices; wireless and passive sensors; self-powered sensors; RF MEMS devices and systems
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shurong Dong

E-Mail Website
Guest Editor
College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China
Interests: resonators; SAW; FBAR; wearable/implantable electronics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics has emerged as a powerful tool that makes substantial contributions in modern chemistry or biology research. Conceptually, the idea of microfluidics precisely manipulates minute amounts of fluids (pL-nL) in microscale chips fabricated with standard semiconductor industry or other microfabrication approaches. These microfluidic devices, or so-called micro total analysis systems (μTAS), show great potentials in broad applications including sensing, separation, analysis, detection, synthesis and diagnosis, with the advantages of sample economy, rapid analysis time, cost effectiveness, compactness and portability, high throughput, and the ability to multiplex and automate. The aim of this Special Issue is to collect new ideas in the integration and application of microfluidic devices. We invite innovative and original researchers to contribute to the Special Issue with their prestigious work in the related topics, including but not limited to:

  • advanced micro/nanofabrication
  • electrokinetics, electrowetting and dielectrophoresis
  • acoustofluidics and optofluidics
  • sensor technology
  • diagnostics and therapy
  • other microfluidic applications

Dr. Zhen Cao
Prof. Dr. Weipeng Xuan
Prof. Dr. Shurong Dong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced micro/nanofabrication
  • electrokinetics, electrowetting and dielectrophoresis
  • acoustofluidics and optofluidics
  • sensor technology
  • diagnostics and therapy
  • other microfluidic applications

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Published Papers (2 papers)

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Research

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12 pages, 1978 KiB  
Communication
Optimizing Sensitivity in a Fluid-Structure Interaction-Based Microfluidic Viscometer: A Multiphysics Simulation Study
by Adil Mustafa, Merve Ertas Uslu and Melikhan Tanyeri
Sensors 2023, 23(22), 9265; https://doi.org/10.3390/s23229265 - 18 Nov 2023
Viewed by 1285
Abstract
Fluid-structure interactions (FSI) are used in a variety of sensors based on micro- and nanotechnology to detect and measure changes in pressure, flow, and viscosity of fluids. These sensors typically consist of a flexible structure that deforms in response to the fluid flow [...] Read more.
Fluid-structure interactions (FSI) are used in a variety of sensors based on micro- and nanotechnology to detect and measure changes in pressure, flow, and viscosity of fluids. These sensors typically consist of a flexible structure that deforms in response to the fluid flow and generates an electrical, optical, or mechanical signal that can be measured. FSI-based sensors have recently been utilized in applications such as biomedical devices, environmental monitoring, and aerospace engineering, where the accurate measurement of fluid properties is critical to ensure performance and safety. In this work, multiphysics models are employed to identify and study parameters that affect the performance of an FSI-based microfluidic viscometer that measures the viscosity of Newtonian and non-Newtonian fluids using the deflection of flexible micropillars. Specifically, we studied the impact of geometric parameters such as pillar diameter and height, aspect ratio of the pillars, pillar spacing, and the distance between the pillars and the channel walls. Our study provides design guidelines to adjust the sensitivity of the viscometer toward specific applications. Overall, this highly sensitive microfluidic sensor can be integrated into complex systems and provide real-time monitoring of fluid viscosity. Full article
(This article belongs to the Special Issue Integration and Application of Microfluidic Sensors)
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Review

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25 pages, 3167 KiB  
Review
Microfluidic-Based Electrical Operation and Measurement Methods in Single-Cell Analysis
by Xing Liu and Xiaolin Zheng
Sensors 2024, 24(19), 6359; https://doi.org/10.3390/s24196359 - 30 Sep 2024
Viewed by 669
Abstract
Cellular heterogeneity plays a significant role in understanding biological processes, such as cell cycle and disease progression. Microfluidics has emerged as a versatile tool for manipulating single cells and analyzing their heterogeneity with the merits of precise fluid control, small sample consumption, easy [...] Read more.
Cellular heterogeneity plays a significant role in understanding biological processes, such as cell cycle and disease progression. Microfluidics has emerged as a versatile tool for manipulating single cells and analyzing their heterogeneity with the merits of precise fluid control, small sample consumption, easy integration, and high throughput. Specifically, integrating microfluidics with electrical techniques provides a rapid, label-free, and non-invasive way to investigate cellular heterogeneity at the single-cell level. Here, we review the recent development of microfluidic-based electrical strategies for single-cell manipulation and analysis, including dielectrophoresis- and electroporation-based single-cell manipulation, impedance- and AC electrokinetic-based methods, and electrochemical-based single-cell detection methods. Finally, the challenges and future perspectives of the microfluidic-based electrical techniques for single-cell analysis are proposed. Full article
(This article belongs to the Special Issue Integration and Application of Microfluidic Sensors)
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