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Separations
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Application of Separation and/or Purification Technology in Natural Products, Newly...
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Application of Separation and/or Purification Technology in Natural Products, Newly Synthetic Candidates, and Pharmaceuticals

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 4366

Special Issue Editors

Dr. Yasser A. El-Amier

E-Mail Website
Guest Editor
Department of Botany, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Interests: chemical ecology; plant conservation; biological activity; chemical contamination
Special Issues, Collections and Topics in MDPI journals
Dr. Ahmed A. Al-karmalawy

E-Mail Website
Guest Editor
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt
Interests: medicinal chemistry; organic chemistry; computational chemistry; drug design; drug repurposing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wild plants are a source of biologically active substances with therapeutic benefits that have been reported and utilized over time by a wide range of individuals to treat a wide range of disorders. Plant-derived medicinal products have attracted the attention of scientists around the world for many years due to their minimal side effects and positive effects on human health. Nowadays, separation and/or purification technology constitute a crucial step in the process of new drug development. The separation of new isolates from natural and/or synthetic sources requires a consecutive purification technique to be available for biological evaluations. The advances in both separation and purification techniques lead to great advances in the process of drug discovery. Therefore, the introduction of new pharmaceuticals requires efficient pathways for separation and/or purification.

This Special Issue focuses on the methods employed in the separation and purification of new isolates, drug candidates, or pharmaceuticals from natural or synthetic sources. Manuscripts should focus on—but are not limited to—the following topics:

  • Application of separation and/or purification technology.
  • Separation and purification of  natural products.
  • Purification of  newly synthetic candidates and pharmaceuticals.
  • Novel separation and/or purification techniques.
  • Separation and purification in the process of drug discovery.
  • Antimicrobial and antiviral activities of plant extracts.
  • Antioxidant, allelopathic, and insecticidal activities plant extracts.

Original research papers, reviews and short communications are welcome.

Dr. Yasser A. El-Amier
Dr. Ahmed A. Al-karmalawy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • separation
  • purification
  • natural products
  • synthetic candidates
  • drug development
  • green chemistry
  • natural products
  • bioactivity

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Published Papers (2 papers)

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Research

11 pages, 626 KiB  
Article
Phytotoxicity of Rich Oxygenated Terpenes Essential Oil of Prosopis farcta against the Weed Dactyloctenium aegyptium
by Ahmed M. Abd-ElGawad, Abdulaziz M. Assaeed, Abd El-Nasser El Gendy, Luisa Pistelli, Basharat A. Dar and Abdelsamed I. Elshamy
Separations 2023, 10(6), 361; https://doi.org/10.3390/separations10060361 - 18 Jun 2023
Cited by 1 | Viewed by 1752
Abstract
Weeds are considered the main reason for crop yield loss in the world. Weed control and management include various treatments such as cultural, physical, chemical, and biological methods. Chemical control of weeds is the most common method; however, the application of commercial synthetic [...] Read more.
Weeds are considered the main reason for crop yield loss in the world. Weed control and management include various treatments such as cultural, physical, chemical, and biological methods. Chemical control of weeds is the most common method; however, the application of commercial synthetic herbicides caused several dangerous hazards in the environment including the appearance of resistant weed biotypes. Prosopis farcta (Banks & Sol.) J.F.Macbr. (Family: Fabaceae), is a common weed plant in the Middle East, where it is hard to eliminate due to its deep and overlapped roots. On the other side, it has many traditional uses around the world. Herein, the essential oil (EO) of P. farcta above-ground parts was extracted via hydrodistillation techniques and then analyzed using gas chromatography-mass spectroscopy (GC-MS). From the GC-MS analysis, 47 compounds were identified with a relative concentration of 98.02%, including terpenes as the main components (95.08%). From overall identified compounds, cubenol (19.07%), trans-chrysanthenyl acetate (17.69%), torreyol (8.28%), davana ether (3.50%), camphor (3.35%), and farnesyl acetone (3.13%) represented the abundant constituents. Furthermore, the phytotoxic activity of the P. farcta EO was assessed against the weed Dactyloctenium aegyptium (L.) Willd. The EO of P. farcta, at a concentration of 100 µL L−1, significantly inhibited the germination, seedling shoot growth, and seedling root growth by 64.1, 64.0, and 73.4%, respectively. The results exhibited that the seedling root growth is the most affected followed by the seed germination and seedling shoot growth with respective IC50 at 64.5, 80.5, and 92.9 µL L−1. It can be concluded that weeds are not absolutely harmful, but they may have beneficial uses, such as, for example as a source of phytochemicals with application in weed control practices (bioherbicides). It is advised to conduct additional research to characterize the allelopathic action of the major chemicals in their pure form, either alone or in combination, against a variety of weeds. Full article
(This article belongs to the Special Issue Application of Separation and/or Purification Technology in Natural Products, Newly Synthetic Candidates, and Pharmaceuticals)
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17 pages, 4852 KiB  
Article
Rational Design, Synthesis, Separation, and Characterization of New Spiroxindoles Combined with Benzimidazole Scaffold as an MDM2 Inhibitor
by Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Abdullah Saleh Alamary, Marwa M. Abu-Serie, Alexander Dömling, Muhammad Shafiq, Zaheer Ul-Haq and Assem Barakat
Separations 2023, 10(4), 225; https://doi.org/10.3390/separations10040225 - 24 Mar 2023
Cited by 5 | Viewed by 1651
Abstract
Rational design for a new spiroxindoles, combined with a benzimidazole scaffold to identify a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The desired spiroxindoles were achieved via a [3+2] cycloaddition reaction approach which afforded the cycloadducts with four asymmetric [...] Read more.
Rational design for a new spiroxindoles, combined with a benzimidazole scaffold to identify a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The desired spiroxindoles were achieved via a [3+2] cycloaddition reaction approach which afforded the cycloadducts with four asymmetric centers separated in an excellent regioselective and diastereoselective compound. The separated spiroxindoles were subjected to a set of biochemical assays including an NCI cell panel assay, MTT assay, and MDM2 binding analysis by a microscale thermophoresis assay. The anticancer reactivity for the tested compounds showed IC50 (µM) in the range between 3.797–6.879 µM, and compound 7d with IC50 = 3.797 ± 0.205 µM was the most active candidate between the series. The results showed promising results that identified that compound 7a could be inhibited the MDM2 with KD = 2.38 μm. Compound 7a developed a network of interactions with the MDM2 receptor studied in silico by molecular docking. Full article
(This article belongs to the Special Issue Application of Separation and/or Purification Technology in Natural Products, Newly Synthetic Candidates, and Pharmaceuticals)
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