Green Extraction Processes to Recover Natural Bioactive Compounds from Food By-Products

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: 10 May 2025 | Viewed by 961

Special Issue Editors


E-Mail Website
Guest Editor
Department of Agronomy, Food, Natural Resources, Animals, and Environment—DAFNAE, University of Padova, 35020 Legnaro, Italy
Interests: polyphenols; green technologies; nonthermal technologies; polyphenol oxidase; functional foods; food by-products
Department of Agronomy, Food, Natural Resources, Animals and Environment—DAFNAE, University of Padova, Viale Università 16, 35020 Agripolis, Italy
Interests: food quality; food enzymology; natural antioxidants; valorisation of food by-products; functional foods

Special Issue Information

Dear Colleagues,

One major and growing portion of the world's food production is the generation of food by-products. While these by-products pose challenges, they offer a unique opportunity as low-cost, renewable, and abundant resources for extracting natural bioactive compounds. However, the challenge lies in identifying the most efficient extraction processes that preserve the integrity of these sensitive bioactive compounds. Traditional extraction techniques often degrade the quality and potency of these components, making it critical to explore alternative approaches. Emerging green technologies—such as microwave-assisted extraction, ultrasound-assisted extraction, etc.,—are increasingly being recognized for their ability to overcome these limitations, offering innovative and sustainable solutions.

Despite the benefits, even these novel techniques must be applied correctly to optimize the quality of the extracted compounds. Achieving this requires careful attention to various process aspects, including the extraction parameters (e.g., choice of solvent, temperature, solid–liquid ratio, etc.), sample preparation methods, and the implementation of pre- and post-treatments. In this respect, developing more effective and sustainable extraction processes is essential to fully realize the potential of novel technologies.

This Special Issue aims to fill the gap in the literature by sharing cutting-edge knowledge on optimizing these processes and utilizing food by-products. We invite you to contribute your research articles, communications, or reviews exploring novel bioactive compounds extraction processes from food by-products.

Dr. Peyman Ebrahimi
Dr. Anna Lante
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green technologies
  • extraction methods
  • polyphenols
  • natural antioxidants
  • food by-products

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 4538 KiB  
Article
Antimicrobial Profiling of Piper betle L. and Piper nigrum L. Against Methicillin-Resistant Staphylococcus aureus (MRSA): Integrative Analysis of Bioactive Compounds Based on FT-IR, GC-MS, and Molecular Docking Studies
by Budiman Yasir, Suwahyuni Mus, Sitti Rahimah, Rein Mostatian Tandiongan, Kasandra Putri Klara, Nurul Afrida, Nur Rezky Khairun Nisaa, Risna Risna, Agum Wahyudha Jur, Gemini Alam and Abdul Rohman
Separations 2024, 11(11), 322; https://doi.org/10.3390/separations11110322 - 8 Nov 2024
Viewed by 758
Abstract
This study explored the antimicrobial potential of Piper betle L. (PBL) and Piper nigrum L. (PNL) extracts against MRSA. Plant parts including stem, leaf, and fruit were extracted using aquadest, methanol, and hexane, resulting in 18 distinct extracts. FT-IR combined with cluster analysis [...] Read more.
This study explored the antimicrobial potential of Piper betle L. (PBL) and Piper nigrum L. (PNL) extracts against MRSA. Plant parts including stem, leaf, and fruit were extracted using aquadest, methanol, and hexane, resulting in 18 distinct extracts. FT-IR combined with cluster analysis (CA) categorized the extracts, and anti-MRSA activity was assessed through the paper disk diffusion method. The most potent extracts were further analyzed using GC-MS to identify bioactive compounds. Additionally, molecular docking studies were conducted for MRSA protein targets (4DKI, 6H5O, and 4CJN). The hexane extract of PNL and the aqueous extract of PBL fruit showed the strongest inhibitory effects. GC-MS identified piperine (14.22%) and diisooctyl phthalate (14.67%) as major compounds, with piperolein B, piperanine, β-caryophyllene oxide, and α-caryophylladienol as minor compounds in the hexane extract of PNL, while hydroxychavicol (81.89%) and chavibetol (12.01%) were predominant in the aquadest extract of PBL. Molecular docking revealed that piperolein B and piperine had strong binding affinities to MRSA proteins 4DKI, 6H5O, and 4CJN, comparable to ciprofloxacin. In conclusion, this study confirms the potential of PBL and PNL as sources of novel anti-MRSA agents, supporting further research to develop new therapies. Full article
Show Figures

Figure 1

Back to TopTop