Green Separation and Purification Technology

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Separation Engineering".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1518

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School of Chemical Engineering, Sichuan University, Chengdu 650061, China
Interests: green chemistry; applied chemistry; pharmaceutics; natural products; polymers
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Special Issue Information

Dear Colleagues,

There is significant interest from the scientific community and increasing industrial demand to research and develop green separation technologies. The road toward sustainable and cleaner strategies depends on the development and application of methods, solvents, and materials that have fewer risks to the environment and health and consume less energy. This Special Issue aims to provide some instructive reviews and research in the following areas: green chemistry, separation science, analytical tests, chemical engineering, environmental science, natural chemicals, pharmaceutical chemistry, agricultural products, functional foods, traditional herbs, nutraceuticals, cosmetics, biorefinery, etc.

This Special Issue, “Green Separation and Purification Technology”, seeks to cover the latest developments in friendly separation mediums, strategies, processes and technologies. The topics include, but are not limited to, the following:

  • Applications of new green solvents;
  • New solvent-free technologies;
  • Green extraction and purification techniques;
  • Combined and hybrid extraction/enrichment/purification/post-treatment techniques;
  • Green sampling and pre-treatment techniques;
  • Life cycle assessment, energy consumption and comprehensive evaluation for green separation strategies;
  • Challenges and bottlenecks in the current development of green separation technologies;
  • Innovative materials for green separation techniques.

Prof. Dr. Shun Yao
Guest Editor

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Published Papers (2 papers)

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Research

13 pages, 1988 KiB  
Article
Extraction and Counter-Current Separation of Phenylpropanoid Glycosides from Pedicularis oederi Vahl by Deep Eutectic Solvent
by Yao Wang, Jun Dai, Xiaoting Zhang, Yuhan Wang, Fangfang He, Lu Liang, Duojie Longzhu and Denglang Zou
Separations 2024, 11(11), 323; https://doi.org/10.3390/separations11110323 - 8 Nov 2024
Viewed by 418
Abstract
Deep eutectic solvents (DESs) are mixtures of organic compounds displaying excellent solvent properties while keeping an ecofriendly character. In this study, DESs have been applied to the extraction of phenylpropanoid glycosides from Pedicularis oederi Vahl, successively separated by means of counter-current chromatography. Firstly, [...] Read more.
Deep eutectic solvents (DESs) are mixtures of organic compounds displaying excellent solvent properties while keeping an ecofriendly character. In this study, DESs have been applied to the extraction of phenylpropanoid glycosides from Pedicularis oederi Vahl, successively separated by means of counter-current chromatography. Firstly, the ultrasonic-assisted extraction conditions were optimized by response surface methodology, and the results showed phenylpropanoid glycosides could be well extracted under the optimized extraction conditions with deep eutectic solvents. Then, the sample was separated by counter-current chromatography using ethyl acetate/aqueous solution of choline chloride and glycerol (6:6, v/v) as the solvent system. In about 360 min, four phenylpropanoid glycosides, including 31.6 mg of echinacoside, 65.3 mg of Jionoside A1, 28.9 mg of Forsythoside B, 74.1 mg of verbascoside, and 21.2 mg of kaempferol-3-O-rutinoside were obtained from about 900 mg of the sample. It revealed deep eutectic solvents could be well employed as a green solvent for the extraction and counter-current separation of natural products. Full article
(This article belongs to the Special Issue Green Separation and Purification Technology)
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15 pages, 2136 KiB  
Article
Development, Validation, and Greenness Assessment of Eco-Friendly Analytical Methods for the Determination of Abiraterone Acetate in Pure Form and Pharmaceutical Formulations
by Erten Akbel
Separations 2024, 11(10), 290; https://doi.org/10.3390/separations11100290 - 11 Oct 2024
Viewed by 757
Abstract
This study presents the development and validation of environmentally friendly analytical methods for quantifying Abiraterone Acetate (AA) in both its pure form and commercial pharmaceutical formulations. An optimized High-Performance Liquid Chromatography (HPLC) method was developed using an Agilent Extend C18 column (250 mm [...] Read more.
This study presents the development and validation of environmentally friendly analytical methods for quantifying Abiraterone Acetate (AA) in both its pure form and commercial pharmaceutical formulations. An optimized High-Performance Liquid Chromatography (HPLC) method was developed using an Agilent Extend C18 column (250 mm × 4.6 mm, 5 μm) at 25 °C. The mobile phase consisted of formic acid and ethanol in isocratic mode, with a flow rate of 1.0 mL min−1, and detection was performed at 253 nm. The spectrophotometric method involved a comprehensive evaluation of AA’s spectral properties in various solvents, with ultrapure water providing the most suitable spectra for analysis at 253 nm. Both methods were validated according to ICH guidelines, demonstrating selectivity, linearity, accuracy, precision, detection and quantification limits, and robustness, with correlation coefficients exceeding 0.999 across the 5–30 μg mL−1 concentration range. Comparative statistical analysis using Student’s t-test and Fisher’s F-test showed no significant differences between the two methods. The environmental impact of both methods was assessed using AGREE and GAPI software, confirming their sustainability. These validated methods offer reliable and eco-friendly approaches for the quantitative analysis of AA in tablet formulations, promoting safer and greener laboratory practices in pharmaceutical analysis. Full article
(This article belongs to the Special Issue Green Separation and Purification Technology)
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