Regio- and Stereoselectivity in Cycloaddition Reactions
A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".
Deadline for manuscript submissions: closed (30 August 2022) | Viewed by 8434
Special Issue Editor
Interests: cycloaddition reactions; nitrocompounds; cycloaddition; heterocycles; reaction mechanisms; organic reactivity; DFT calculations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Cycloaddition reactions are the most universal protocol for the preparation of a wide range of carbo- and heterocyclic molecular systems. In this way, it is possible to synthesize three-, four-, five-, six- (etc.) membered cyclic molecules, including almost any combination of heteroatoms. Most of these types of processes proceed with high yields and selectivity. Additionally, cycloaddition reactions are realized with full atomic economy. Therefore, this class of organic processes is valuable from the point of view of green chemistry.
The latest discoveries shed new insight into the mechanisms of cycloaddition processes, as well as the factors that stimulate chemo-, regio-, and stereoselectivity. It should be noted that in the case of reactions involving functionalized addents, the cycloaddition process can take place on two regioisomeric paths, within which two stereoisomeric forms are possible. Sometimes there is a perfect symmetry between the yields of the individual pair of isomers. This symmetry may be broken due to the occurrence of certain electronic and steric effects. Further symmetry breakdown in the regio- and stereochemistry of cycloaddition can take place when the one-step mechanism gives way to the stepwise mechanism with a biradical or zwitterionic intermediate. So, this issue should attract significant attention from organic chemists.
This Special Issue is especially dedicated to the presentation of new, important discoveries in the mentioned field. In particular, we invite short laboratory notes, including rare cases of the reaction course, full papers with comprehensive studies, kinetic considerations about substituent and/or solvent effects, as well as activation parameters, preparation of analogs of natural products, mechanistic experimental and/or theoretical studies, prediction of the reactivity and selectivity on the basis of modern organic theories. Review articles by experts in the field are also welcome.
Prof. Dr. Radomir Jasiński
Guest Editor
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Keywords
- Cycloaddition
- Regio- and stereoselectivity
- Reaction mechanisms
- Zwitterions and biradicals
- Quantum-chemical computational study
- Molecular electron density theory
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