Dinoflagellate Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Marine and Freshwater Toxins".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 8236
Special Issue Editor
Special Issue Information
Dear Colleagues,
Almost a century ago, the source of the deadly marine toxin saxitoxin was finally discovered to be a dinoflagellate. However it was many years after that before the chemical structure of saxitoxin was characterized. Following this breakthrough, additional saxitoxin congeners were reported, and many new and different dinoflagellate toxins were discovered. These toxins are structurally different from most other natural products, often displaying novel biological activity. Concurrently, the number of toxic dinoflagellate species has also expanded. Biochemical studies show that many of these dinoflagellate toxins are derived from acetate, albeit by novel non-traditional pathways that result in polyketides and hybrid polyketides representing linear, macrocyclic, and ladder-frame compounds. As the list of new dinoflagellate toxins and sources continues to grow, there is a two-fold outcome. Firstly, a compilation of these new toxins and their toxicity is critical for monitoring seafood safety, and secondly, their study will lead to a better understanding of the enzymatic and genetic factors that control their production.
Prof. Jeffrey L. Wright
Guest Editor
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Keywords
- new structural classes
- new structures
- bioactivity
- producing species
- new locations
- biosynthesis
- genetics
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