HIV Vaccine Development and Clinical Trails

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "HIV Vaccines".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1766

Special Issue Editor


E-Mail Website
Guest Editor
Animal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, Bethesda, MD, USA
Interests: HIV vaccine development; immunology of HIV vaccines; non-human primate model for HIV vaccine development and testing; Innate response to anti-HIV vaccines; T cell response to anti-HIV vaccines; anti-HIV immune responses targeting V1V2

Special Issue Information

Dear Colleagues,

The HIV pandemic still remains a burden for many people worldwide. In 2022, approximately 1.3 million new HIV infections were recorded globally, yet only 76% of people living with the virus had access to antiretroviral therapy in that same year. It is clear that the development of an effective anti-HIV vaccine will be essential to control the HIV pandemic. Pre-clinical and clinical studies conducted in animals and human volunteers are pivotal to develop novel anti-HIV vaccine strategies and to test their safety and immunogenicity.

Vaccines is a peer-reviewed international journal focused on clinical vaccine research, utilization, and immunization and we are pleased to invite you to submit your manuscripts to one of this journal’s Special Issue titled ‘HIV Vaccine Development and Clinical Trials.’

The aim of this Special Issue is to share pre-clinical and clinical studies pertaining to new anti-HIV vaccine technologies, improvement in already tested anti-HIV vaccines, and the implementation of novel strategies, such as the use of different immunogens or adjuvants, to increase the immune responses elicited by anti-HIV vaccines. 

We welcome both original research articles and reviews. Research areas may include (but not limited to) the following:

  • Development of novel anti-HIV vaccines and immunogens;
  • Development of novel adjuvants in the contest of anti-HIV vaccines;
  • Induction of anti-HIV broadly neutralizing antibodies;
  • Testing of novel anti-HIV vaccines in preclinical studies in animal models;
  • Testing of novel anti-HIV vaccines in clinical trials in human volunteers;
  • Development of assays to investigate immune responses to anti-HIV vaccination;
  • Investigation of immune correlates of protection in preclinical and clinical studies.

We look forward to receiving your contributions.

Dr. Massimiliano Bissa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV vaccine
  • HIV vaccine clinical trial
  • HIV vaccine adjuvant
  • correlate of decreased HIV risk
  • HIV immunogen
  • broadly neutralizing antibodies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 4717 KiB  
Article
Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates
by Bhawna Sharma, Elena Bekerman, Hoa Truong, Johnny Lee, Maria Gamez-Guerrero, Archana Boopathy, Rohit Mital, Katell Bidet Huang, Sarah Ahmadi-Erber, Raphaela Wimmer, Sophie Schulha, Henning Lauterbach, Klaus Orlinger, Silpa Suthram, Mark G. Lewis, Wade Blair, Tariro Makadzange, Romas Geleziunas, Jeffrey P. Murry and Sarah Schmidt
Vaccines 2024, 12(7), 735; https://doi.org/10.3390/vaccines12070735 - 2 Jul 2024
Viewed by 1401
Abstract
Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV) arenavirus-based vectors expressing simian immunodeficiency virus (SIV) Gag and Envelope (Env) [...] Read more.
Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV) arenavirus-based vectors expressing simian immunodeficiency virus (SIV) Gag and Envelope (Env) immunogens in treatment-naïve non-human primates. Heterologous regimens with non-replicating and replicating vectors elicited more robust SIV IFN-γ responses than a homologous regimen, and replicating vectors elicited significantly higher cellular immunogenicity than non-replicating vectors. The heterologous regimen elicited high anti-Env antibody titers when administered intravenously, with replicating vectors inducing significantly higher titers than non-replicating vectors. Intramuscular immunization resulted in more durable antibody responses than intravenous immunization for both vector platforms, with no difference between the replicating and non-replicating vectors. Overall, both replicating and non-replicating arenavirus vectors generated robust T- and B-cell-mediated immunity to SIV antigens in treatment-naïve non-human primates, supporting further evaluation of these vectors in a clinical setting for HIV therapy. Full article
(This article belongs to the Special Issue HIV Vaccine Development and Clinical Trails)
Show Figures

Figure 1

Back to TopTop