Microbial Antigen Delivery
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (31 July 2018) | Viewed by 10341
Special Issue Editor
Interests: extremophiles; haloarchaea; microbial genomics; purple membrane; gas vesicle nanoparticles; vaccines and therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many strategies are currently being developed to expand the repertoire of preventative and therapeutic vaccines against a variety of diseases. Diverse microbial systems are being utilized, from Archaea to Bacteria, Fungi, and Viruses, which offer advantages over traditional vaccines. Notable among them are recombinant vectors, liposomes and nanoparticles, and other customizable delivery vehicles that are designed to increase immunogenicity and efficacy, while reducing toxicity and adverse effects. Compared to live-attenuated, inactivated or killed pathogens, microbial antigen delivery systems may offer greater safety, increased stability, optimized presentation, enhanced adjuvant effect, and improved immunogenicity, potentially reducing the immunization and dosage requirements. They hold the promise of eliciting a full adaptive immune response as well as long-term systemic humoral and cell-mediated immunity. As a result, microbial antigen delivery systems may help cure some of the most widespread and pervasive as well as rare and orphaned diseases. Of particular importance in the 21st century are emerging and re-emerging infectious diseases, long-standing tropical infectious diseases, and hematological malignancies and solid tumors. This special issue of Vaccines will cover topics relevant to new and developing systems for microbial antigen delivery.
Prof. Dr. Shiladitya DasSarma
Guest Editor
Manuscript Submission Information
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Keywords
- expression systems
- customizable delivery vehicles
- adjuvant effects
- immunogenicity
- therapeutic vaccines
- cancer vaccines
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