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Veterinary Sciences
Special Issues
Genetic Biomarkers, Molecular Markers and Pathogenesis of Livestock Disease
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Genetic Biomarkers, Molecular Markers and Pathogenesis of Livestock Disease

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 6129

Special Issue Editor

Prof. Dr. Yafei Cai

E-Mail Website
Guest Editor
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Interests: animal genetic regulation; animal breeding and reproduction; cattle science; animal physiology

Special Issue Information

Dear Colleagues,

Along with our understanding of diseases, the incidence of hereditary diseases in livestock has been increasing year by year. In 1980, there were 346 known hereditary diseases (110 in cattle, 148 in pigs and 88 in sheep). There are more than 400 kinds of diseases, such as: bovine umbilical hernia, penis and foreskin defects, hydrocephalus, tendon contracture, inguinal hernia, cryptorchidism, umbilical hernia, anal and rectal atresia in pigs, etc. In hereditary diseases, they belong to the gene or chromosome disease. However, we know very little about the scientific reasons behind the phenotypes. To promote the diagnosis, treatment and prevention of animal genetic disease, it is indispensable for scientists to identify new molecular markers and seek the real mechanisms of the incidence of disease.

In this Special Issue, we welcome summaries on the up-to-date findings about novel genetic biomarkers, molecular mechanisms or new technology, focusing on livestock disease. Moreover, we want to define novel genetic or molecular mechanisms of animal disease. We will highlight searching for the relevant and novel targets or drugs and apply them to animal breeding and reduce the burden of animal disease. The above research will lead to new and exciting future studies.

We welcome contributions in various forms (original research, reviews, mini-reviews, methods, perspective articles, etc.) highlighting, but not limited to, the following subjects:

  1. Updating the knowledge about the regulatory mechanism of animal breeding in multiple stress responses.
  2. Elucidating the novel endocrine regulatory mechanism of animal pathological physiology.
  3. Seeking the molecular mechanisms of animal genetic disease.
  4. Identifying new molecular markers linking animal economic traits (via various omics methods: proteomics, genomics, transcriptomics, metabolomics, multiple omics analysis, etc.).
  5. Making innovative and challenging hypotheses aimed at reducing the burden of animal breeding or disease, based on the existing scientific evidence.

Prof. Dr. Yafei Cai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • livestock
  • molecular genetics
  • molecular biological technology
  • animal breeding
  • animal genetic disease
  • pathological physiology
  • biomarker

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Published Papers (2 papers)

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Research

12 pages, 993 KiB  
Article
Case–Control Study: Endogenous Procalcitonin and Protein Carbonylated Content as a Potential Biomarker of Subclinical Mastitis in Dairy Cows
by Giulia Sala, Chiara Orsetti, Valentina Meucci, Lucia De Marchi, Micaela Sgorbini and Francesca Bonelli
Vet. Sci. 2023, 10(12), 670; https://doi.org/10.3390/vetsci10120670 - 24 Nov 2023
Cited by 1 | Viewed by 2924
Abstract
Procalcitonin (PCT) and protein carbonylated content (PCC) are promising biomarkers for bacterial infection and inflammation in veterinary medicine. This study examined plasma PCT and PCC levels in healthy cows (H) and cows with subclinical mastitis (SCM). A total of 130 cows (65 H [...] Read more.
Procalcitonin (PCT) and protein carbonylated content (PCC) are promising biomarkers for bacterial infection and inflammation in veterinary medicine. This study examined plasma PCT and PCC levels in healthy cows (H) and cows with subclinical mastitis (SCM). A total of 130 cows (65 H and 65 SCM) were included in this study. Blood samples were collected, and plasma was frozen at −80 °C. PCT levels were determined using a bovine procalcitonin ELISA kit, while PCC was measured following the methodology of Levine et al. Statistical analysis revealed a significant difference in PCT levels between H (75.4 pg/mL) and SCM (107.3 pg/mL) cows (p < 0.001) and significantly lower concentrations of PCC in the SCM group (H: 0.102 nmol/mL/mg, SCM: 0.046 nmol/mL/mg; p < 0.001). The PCT cut-off value for distinguishing healthy and subclinical mastitis animals was >89.8 pg/mL (AUC 0.695), with a sensitivity of 66.2% and specificity of 69.2%. PCT showed potential value as a diagnostic tool to help in decision making for subclinical mastitis cases, while PCC requires further studies to investigate the trend of this biomarker during localized pathology. Full article
(This article belongs to the Special Issue Genetic Biomarkers, Molecular Markers and Pathogenesis of Livestock Disease)
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17 pages, 6451 KiB  
Article
Transcriptome Profile Analysis Identifies Candidate Genes for the Melanin Pigmentation of Skin in Tengchong Snow Chickens
by Xiannian Zi, Xuehai Ge, Yixuan Zhu, Yong Liu, Dawei Sun, Zijian Li, Mengqian Liu, Zhengrong You, Bo Wang, Jiajia Kang, Tengfei Dou, Changrong Ge and Kun Wang
Vet. Sci. 2023, 10(5), 341; https://doi.org/10.3390/vetsci10050341 - 11 May 2023
Cited by 4 | Viewed by 2268
Abstract
Tengchong Snow chickens are one of the most precious, black-boned chickens in Yunnan province and usually produce black meat. However, we found a small number of white meat traits in the chicken population during feeding. In order to determine the pattern of melanin [...] Read more.
Tengchong Snow chickens are one of the most precious, black-boned chickens in Yunnan province and usually produce black meat. However, we found a small number of white meat traits in the chicken population during feeding. In order to determine the pattern of melanin deposition and the molecular mechanism of formation in the Tengchong Snow chicken, we measured the luminance value (L value) and melanin content in the skin of black meat chickens (Bc) and white meat chickens (Wc) using a color colorimeter, ELISA kit, and enzyme marker. The results showed that the L value of skin tissues in black meat chickens was significantly lower than that of white meat chickens, and the L value of skin tissues gradually increased with an increase in age. The melanin content of skin tissues in black meat chickens was higher than that of white meat chickens, and melanin content in the skin tissues gradually decreased with an increase in age, but this difference was not significant (p > 0.05); the L value of skin tissues in black meat chickens was negatively correlated with melanin content, and the correlation coefficient was mostly above −0.6. In addition, based on the phenotypic results, we chose to perform the comparative transcriptome profiling of skin tissues at 90 days of age. We screened a total of 44 differential genes, of which 32 were upregulated and 12 were downregulated. These DEGs were mainly involved in melanogenesis, tyrosine metabolism and RNA transport. We identified TYR, DCT, and EDNRB2 as possible master effector genes for skin pigmentation in Tengchong Snow black meat chickens through DEGs analysis. Finally, we measured the mRNA of TYR, DCT, MC1R, EDNRB2, GPR143, MITF, and TYRP1 genes through a quantitative real-time polymerase chain reaction (qPCR) and found that the mRNA of all the above seven genes decreased with increasing age. In conclusion, our study initially constructed an evaluation system for the black-boned traits of Tengchong Snow chickens and found key candidate genes regulating melanin deposition, which could provide an important theoretical basis for the selection and breeding of black-boned chickens. Full article
(This article belongs to the Special Issue Genetic Biomarkers, Molecular Markers and Pathogenesis of Livestock Disease)
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