Herpesvirus Latency
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (15 December 2020)
Special Issue Editors
Interests: viral persistence; viral latency; mechanisms of transcriptional control; epigenetic regulation of latency; herpesvirus pathogenesis; herpesvirus latency; viral neurovirulence and neuroinvasion
Special Issue Information
Dear Colleagues,
Herpesviruses are a large family of DNA viruses that infect a wide range of animals, including mollusks and vertebrates. They share the ability to persist in their hosts and establish lifelong latent infections from which they periodically reactivate and produce infectious virus. This Special Issue will focus on herpesvirus infections of humans and specifically focus on mechanisms of how these viruses maintain and regulate latency. Recent advances in model systems to study latency in vitro as well as sensitive techniques to analyses populations of latently infected cells in vivo have illuminated the dynamic state of latent infections. This issue will include a survey of advances in our understanding of the epigenetic control of latency, single-cell analyses of latency, as well as the role of noncoding RNAs in regulating the fine balance of latency and reactivation. New models of in vitro latency, such as iPSC cultures and organoids, as well as new in vivo models, such of humanized mice, will also be highlighted. Finally, this issue will discuss the correlations of these experimental approaches with recent high-resolution analyses of the dynamic state of herpesvirus infections in humans in an attempt to provide a comprehensive view of herpesvirus latency.
Dr. David C. Bloom
Guest Editor
Dr. Jasbir Singh
Co-Guest Editor
Manuscript Submission Information
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Keywords
- herpesvirus
- latency
- persistence
- chromatin
- scRNAseq
- epigenetics
- ncRNA
- lncRNA
- miRNA
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