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Molecules, Volume 10, Issue 12 (December 2005) – 4 articles , Pages 1429-1461

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36 KiB

Open AccessArticle

Chromate Oxidation of α-Nitro Alcohols to α-Nitro Ketones: Significant Improvements to a Classic Method

by Tarek Abou Elmaaty and Lyle W. Castle

Molecules 2005, 10(12), 1458-1461; https://doi.org/10.3390/10121458 - 31 Dec 2005

Cited by 7 | Viewed by 7262

Abstract

A series of eight alkyl and aryl α-nitro ketones were prepared by the potassium dichromate oxidation of the corresponding nitro alcohols. Short reaction times allowed for the easy isolation of pure nitro ketones that are devoid of starting materials and/or other oxidation side [...] Read more.

143 KiB

Open AccessArticle

Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

by Naim H. Al-Said, Khaled Q. Shawakfeh and Wasim N. Abdullah

Molecules 2005, 10(12), 1446-1457; https://doi.org/10.3390/10121446 - 31 Dec 2005

Cited by 11 | Viewed by 9657

Abstract

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode. Full article

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131 KiB

Open AccessArticle

An Efficient Protocol for the Solid-phase Synthesis of Malondiamides

by Markus M. Vögtle and Andreas L. Marzinzik

Molecules 2005, 10(12), 1438-1445; https://doi.org/10.3390/10121438 - 31 Dec 2005

Viewed by 7689

Abstract

A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries. Full article

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179 KiB

Open AccessArticle

Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives

by Sonja Merkas, Mladen Litvic, Ivica Cepanec and Vladimir Vinkovic

Molecules 2005, 10(12), 1429-1437; https://doi.org/10.3390/10121429 - 31 Dec 2005

Cited by 19 | Viewed by 10900

Abstract

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries. Full article

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Molecules, Volume 10, Issue 12 (December 2005) – 4 articles , Pages 1429-1461

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