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Article

Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions

by
Gholamhassan Imanzadeh
*,
Farzaneh Ahmadi
,
Mohammadreza Zamanloo
and
Yagoub Mansoori
Department of Chemistry, College of Science, University of Mohaghegh Ardabili, 56199-11367, Ardabil, Iran
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(10), 7353-7362; https://doi.org/10.3390/molecules15107353
Submission received: 19 September 2010 / Revised: 11 October 2010 / Accepted: 11 October 2010 / Published: 21 October 2010
Browse Figures
Versions Notes

Abstract

:
The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a base in the presence of tetrabutylammonium bromide (TBAB). The products were obtained in good to high yields within 2.5-7.0 h. This reaction worked well on linear alkyl fumarates and was not effective with nonlinear alkyl fumarates. Although the reaction was also applicable to acrylates such as n-butyl acrylate, methacrylates and crotonates were not suitable Michael acceptors for this reaction.

Graphical Abstract

1. Introduction

Over the past decade, protection of the environment and waste prevention have been increasingly emphasized by researchers from both academia and industry [1]. For this reason, the elimination or reduce of volatile solvents in organic synthesis is a most important goal in green chemistry [2,3,4]. In this context the replacement of hazardous solvents with environmentally benign solvents or the development of solvent-free synthesis methods have become an important and popular research topic in recent years [5,6,7,8,9,10,11,12,13,14,15]. One of the most fundamental reactions in synthetic organic chemistry is the conjugate addition of nucleophilic species to the β-carbon of α,β-unsaturated systems. Because this process allows the construction of carbon backbones it is very valuable from a synthetic point of view [16]. Along this line, the aza-Michael addition reaction is widely recognized as one of the most important carbon-nitrogen bond–forming reaction in organic synthesis [17]. Most of the products of these reactions have special properties [18]. For instance the β-amino acids that can be obtained from aza-Michael additions between amines and α,β-unsaturated esters are attractive precursors in preparation of a variety of bioactive molecules such as taxol which is an anticancer drug in clinical use [19,20]. The Michael addition reactions of amines to α,β-unsaturated systems are usually carried out in the presence suitable catalysts, including silica-gel [21], ionic liquids [22], palladium [23], BiX3 (X=NO3, OTF) [24,25], pyrolidine-thiourea [26], Amberlyst-15 [27], and Cu-nanoparticles [28].
Neutral amides and imides have very restricted nucleophilicity, but under strong basic conditions, nitrogen anions derived from them can become more convenient nucleophiles in Michael-type additions to α,β-unsaturated compounds [29]. In a literature survey of the use of amides and imides as Michael donors, a few reports were found [30,31,32,33]. For these reasons, and in keeping with our ongoing program on the development of cleaner pathways, we recently reported the aza-Michael additions between phthalimide and alkyl or aryl acrylates in the presence of tetrabutylammonium bromide (TBAB) and 1,4-diazabicyclo[2.2.2]octane (DABCO) under solvent–free conditions [34]. We also studied the Michael addition of phthalimide to symmetrical fumaric esters in ionic liquid media [35].
Herein, we report that aza-Michael addition of 1,2,3,6-tetrahydrophthalimide (1) to symmetrical fumaric esters in the presence of tetrabutylammonium bromide (TBAB) and 1,4-diazabicyclo[2.2.2]-octane (DABCO) provides the corresponding Michael adducts in good yields (Scheme 1). The reaction was carried out under solvent-free conditions at 100 °C with conventional heating. Both the ionic liquid used in our previous work [35], and the TBAB in the present work were found to be recyclable, however recovery of TBAB was easier than recovery of ionic liquid and the latter showed a slight decrease in catalytic activity do in this reaction we decided to replace the ionic liquid with TBAB.
Molecules 15 07353 g001 550
Scheme 1. Aza-Michael addition of imide (1) to fumaric esters.
Scheme 1. Aza-Michael addition of imide (1) to fumaric esters.
Molecules 15 07353 g001

2. Results and Discussion

As a first example, the addition of 1,2,3,6-tetrahydrophthalimide to diethyl fumarate was selected as a model reaction for the optimization reaction conditions and others parameters, such as nature of base and role of solvent. The obtained results of this typical reaction are presented in Table 1. From these results, it was observed that this reaction did not proceed in acetone under the reflux conditions (Table 1, entries 6-9) and other solvents like DMSO, DMF and acetonitrile provided lower yields under similar conditions (Table 1, entries 1-5 and 10-15). The results of Table 1 also show that under solvent-free conditions, in the presence of TBAB, bases like Na2CO3, K2CO3, triethylamine and pyridine all produced the desired product in low yield, while the use of DABCO as base afforded the desired products in excellent yields within a shorter reaction time (2.5 h) (Table 1, entry 20). The reaction did not proceed at all in the absence of solvent and TBAB (Table 1, entries 21-25). Therefore, the use of DABCO, in the presence of TBAB, under solvent-free conditions was selected as the optimal conditions for this model reaction because is advantageous thanks to the elimination of solvents while giving the desired product in excellent yield.
Table
Table 1. Influence of reaction parameters on the addition of 1,2,3,6-tetrahydrophthalimide to diethyl fumarate .
Table 1. Influence of reaction parameters on the addition of 1,2,3,6-tetrahydrophthalimide to diethyl fumarate .
EntrySolventaBaseTime (h)Yield (%)
1DMSONa2CO32410
2DMSOK2CO32415
3DMSOTriethylamine2410
4DMSOPyridine2412
5DMSODABCO2423
6AcetoneNa2CO324-
7AcetoneK2CO324-
8AcetoneTriethylamine24-
9AcetonePyridine24-
10AcetoneDABCO2417
11DMFNa2CO32410
12DMFK2CO32410
13DMFTriethylamine2416
14DMFPyridine2410
15DMFDABCO2420
16TBABbNa2CO32430
17TBABbK2CO32440
18TBABbTriethylamine2425
19TBABbPyridine2418
20TBABbDABCO2:585
21NonecNa2CO324-
22NonecK2CO324-
23NonecTriethylamine24-
24NonecPyridine24-
25NonecDABCO24-
a Reactions were carried out on 1.0 mmol scale of 1,2,3,6-tetrahydrophthalimide with 1.2 equiv of diethylfumarate in the presence of 1.0 equiv base under reflux conditions.b With 0.5 equiv of TBAB at 100 °C.c At 100 °C.
Encouraged by this initial result, the reaction was repeated using the various fumarates in TBAB medium and using DABCO as a base, in the absence of any solvent. The results are summarized in Table 2. The method worked well on linear alkyl fumarates (Table 2, entries 2, 4-11) but did not work on nonlinear alkyl fumarates (Table 2, entries 3, 12). Perhaps the steric factors are responsible for this selectivity.
Table
Table 2. Michael additions of 1,2,3,6-tetahydrophthalimide to fumaric esters in thepresence of DABCO and TBAB.
Table 2. Michael additions of 1,2,3,6-tetahydrophthalimide to fumaric esters in thepresence of DABCO and TBAB.
EntryEsterProductTime(h)Yield(%)a,b
1 Molecules 15 07353 i001 Molecules 15 07353 i0162.0—
2 Molecules 15 07353 i002 Molecules 15 07353 i0172.585
3 Molecules 15 07353 i003 Molecules 15 07353 i0183.0—
4 Molecules 15 07353 i004 Molecules 15 07353 i0193.576
5 Molecules 15 07353 i005 Molecules 15 07353 i0203.572
6 Molecules 15 07353 i006 Molecules 15 07353 i0214.070
7 Molecules 15 07353 i007 Molecules 15 07353 i0224.568
8 Molecules 15 07353 i008 Molecules 15 07353 i0235.063
9 Molecules 15 07353 i009 Molecules 15 07353 i0245.560
10 Molecules 15 07353 i010 Molecules 15 07353 i0256.057
11 Molecules 15 07353 i011 Molecules 15 07353 i0266.555
12 Molecules 15 07353 i012 Molecules 15 07353 i0277.0—
13 Molecules 15 07353 i013 Molecules 15 07353 i0281.590
14 Molecules 15 07353 i014 Molecules 15 07353 i02924.0—
15 Molecules 15 07353 i015 Molecules 15 07353 i03024.0—
a Isolated yield. b All products were novel and characterized by their 1H-NMR, 13C-NMR, IR, MS and elemental analysis data.
Our attempts to react methyl fumarate with Michael donor 1 under the model reaction conditions was unsuccessful (Table 2, entry 1). The reaction gave fumaric acid and imide 1 without the formation of any Michael adduct. We believe that methyl fumarate is more susceptible to hydrolysis under the reaction conditions, due to its smaller groups. The reaction was also successfully applied for the addition of alkyl acrylates such as n-butyl acrylate which gave a 90% yield of the corresponding Michael adduct under the model reaction conditions (Table 1, entry 13). However, it was observed that sterically hindered α,β-unsaturated esters, like methyl methacrylate and ethyl crotonate, were not suitable Michael acceptors for this reaction and the starting materials were completely recovered after 24 h under the model reaction conditions (Table 2, entries 14, 15).

3. Conclusions

We have developed an efficient, simple and new method for aza-Michael addition of 1,2,3,6-tetrahydrophthalimide to symmetrical fumarates in the presence of TBAB under solvent-free conditions. We found that DABCO is the most suitable base for this reaction. It was found that this method selectively works on linear alkyl fumarates and did not occur with non linear alkyl fumarates as well as methyl methacrylate and ethyl crotonoate. Our studies showed that when TBAB was eliminated or replaced with a solvent, no reaction is observed.

4. Experimental

4.1. General

TBAB was purchased from Fluka and DABCO, 1,2,3,6-tetrahydrophthalimide, fumaric acid and alcohols were purchased from Merck. All alkyl fumarates were synthesized in our laboratory according to the literature procedure [36] and their structures were confirmed by IR and 1H-NMR spectroscopy. The progress of the reactions was followed by TLC using silica gel SILIG/UV 254 plates. 1H-NMR (300 MHz) and 13C-NMR (75 MHz) spectra were recorded on a Bruker 300 MHz instrument. IR spectra were recorded on a Buck-Scientific 500 instrument. Mass spectra were recorded on a Shimadzu GC-MS-QP 1000PX. Elemental analysis for C, H, and N were performed using a Heraeus CHN-O-Rapid analyzer. The melting points were determined in open capillaries with a Stuart Melting Point Apparatus and are uncorrected.

4.2. General procedure for Michael addition of 1,2,3,6-tetrahydrophthalimide to symmetrical fumaric esters

A mixture of 1,2,3,6-tetrahydrophthalimide (1.0 mmol), DABCO (1.0 mmol), TBAB (0.5 mmol), and fumaric ester (1.2 mmol) was kept at 100 ˚C in an oil bath for the stipulated time (Table 2). The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to room temperature and dissolved in chloroform (40 mL). TBAB was recovered by the addition of water (15 mL), then collected and dried under vacuum. The chloroform layer was washed with water (3 × 15 ml). The organic layer was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure and the resulting crude material was purified on short silica-gel column with ethyl acetate/n-hexane (2:8) as the eluent.
Diethyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2a): Colorless solid; mp 45-47 ˚C; IR νmax(KBr)/cm-1 2952, 1726, 1458, 985. 1H-NMR (CDCl3) δ ppm: 5.79-5.80 (m, 2H), 5.04 (dd, J = 8.40 Hz and 6.00 Hz, 1H ) 3.97-4.13 (m, 4H), 3.12 (dd, J = 16.50 Hz and 6.00 Hz, 1H), 3.03-3.05 (m, 2H), 2.78 (dd, J = 16.50 Hz and 8.40 Hz, 1H ), 2.44-2.50 (m, 2H), 2.13-2.20 (m, 2H), 1.09-1.21 (m, 6H). 13C-NMR (CDCl3 ) δ ppm: 14.02, 23.28, 33.26, 40.21, 48.76, 60.85, 62.19, 127.38, 167.54, 169.75, 178.84. MS, m/z (%): 324 (37.0, M+ + 1), 277 (61.0), 249 (55.0), 203 (100.0), 177 (8.0), 99 (54.0), 79 (91.0), 70 (24.0), 43 (64.0). Anal. calcd for C16H21NO6: C 59.45, H 6.5, N 4.33; found C 59.71, H 6.34, N 4.69.
Dipropyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2b): Colorless solid; mp 40-41 ˚C; IR νmax(KBr)/cm-1 2955, 1739, 1427, 985. 1H-NMR (CDCl3) δ ppm: 5.78-5.80 (m, 2H). 5.08 (dd, J = 8.40 Hz and 6.35 Hz, 1H), 3.88-4.03 (m, 4H), 3.14 (dd, J = 16.64 Hz and 6.35 Hz, 1H), 3.02-3.04 (m, 2H), 2.80 (dd, J = 16.64 Hz and 8.40 Hz, 1H ), 2.44-2.51 (m, 2H), 2.14-2.20 (m, 2H), 1.47-1.59 (m, 4H), 0.77-0.88 (m, 6H). 13C-NMR (CDCl3) δ ppm: 10.20, 21.78, 23.22, 33.31, 38.90, 48.89, 66.55, 67.66, 127.42, 167.67, 169.90, 178.85. MS, m/z (%): 352 (100.0, M+ + 1 ), 291 (78.5), 363 (26.0), 249 (86.50), 221 (69.0), 203 (83.0), 177 (40.50), 113 (23.50), 79 (87.0), 43 (84.0). Anal. calcd for C18H25NO6: C 61.52, H 7.17, N 3.99; found C 61.15, H 6.92, N 4.22.
Dibutyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2c): Yellow oil; IR νmax(neat)/cm-1 2843, 1727, 1460, 973. 1H-NMR (CDCl3) δ ppm: 5.82-5.89 (m, 2H), 5.54 (dd, J = 8.48 and 6.24 Hz, 1H), 3.98-4.08 (m, 4H), 3.77 (dd, J = 16.80 Hz and 6.24 Hz, 1H), 3.04-3.09 (m, 4H), 2.83 (dd, J = 16.80 Hz, 8.48 Hz, 1H), 2.48-2.55 (m, 2H), 2.18-2.23 (m, 2H), 1.49-1.55 (m, 4H), 1.25-1.31 (m, 4H), 0.83-0.88 (m, 6H). 13C-NMR (CDCl3) δ ppm: 13.62, 18.97, 23.32, 30.45, 33.34, 38.92, 48.92, 64.89, 66.01, 127.45, 167.70, 169.49, 178.88. MS, m/z (%): 379 (17.0, M+), 305 (26.0), 249 (100.0), 221 (64.0), 203 (32.0), 177 (24.0), 79 (47.0), 57 (22.0), 41 (30.0). Anal. calcd for C20H29NO6: C 63.31, H 7.70, N 3.69; found C 63.58, H 7.12, N 3.91.
Dipentyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2d): Pale yellow oil; IR νmax(neat)/cm-1 2924, 1714, 1450, 985. 1H-NMR (CDCl3) δ ppm: 5.85-5.86 (m, 2H), 5.14 (dd, J = 8.48 Hz and 6.30 Hz, 1H), 4.00-4.10 (m, 4H), 3.20 (dd, J = 16.50 Hz and 6.30 Hz, 1H), 3.05-3.08 (m, 2H), 2.87 (dd, 1H, J = 16.50 Hz and 8.48 Hz), 2.52-2.57 (m, 2H), 2.20-2.27 (m, 2H), 1.53-1.60 (m, 4H), 1.24-1.30 (m, 8H), 0.84- 0.88 (m, 6H). 13C-NMR (CDCl3) δ ppm: 17.80, 22.20, 23.24, 28.03, 33.31, 38.90, 48.87, 65.14, 66.25, 127.40, 167.67, 169.91, 178.82. MS, m/z (%): 408 (80.0, M+ + 1), 319 (24.0), 249 (100.0), 221 (56.0), 203 (26.3), 177 (26.0), 79 (48.5), 43 (53.0), 41 (21.0). Anal. calcd for C22H33NO6: C 64.83, H 8.16, N 3.44; found C 64.53, H 7.91, N 3.82.
Dihexyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2e): Yellow oil; IR νmax(neat)/cm-1 2943, 1727, 1472, 985. 1H-NMR (CDCl3) δ ppm: 5.81-5.82 (m, 2H), 5.10 (dd, J = 8.46 Hz and 6.28 Hz, 1H), 3.96-4.08 (m, 4H), 3.16 (dd, J = 16.0 Hz and 6.28 Hz, 1H), 3.04-3.05 (m, 2H), 2.82 (dd, J = 16.0 Hz and 8.46 Hz, 1H), 2.21-2.22 (m, 2H), 2.90-2.11 (m, 2H), 1.48-1.54 (m, 4H), 1.21-1.30 (m, 12H), 0.80-0.87 (m, 6H). 13C-NMR (CDCl3) δ ppm: 20.00, 20.12, 23.32, 25.40, 28.30, 30.40, 31.45, 33.33, 38.91, 48.90, 65.01, 66.15, 127.35, 167.70, 169.94, 178.85. MS, m/z (%): 435 (12.0, M+), 305 (8.0), 249 (100.0), 221 (68.0), 203 (33.5), 177 (29.5), 79 (71.0), 57 (29.0), 43 (63.0), 41 (45.5). Anal. calcd for C24H37NO6: C 66.18, H 8.56, N 3.22; found C 66.23, H 8.18, N 3.61.
Diheptyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2f): Pale yellow oil; IR νmax(neat)/cm-1 2915, 1711, 1462, 976. 1H-NMR (CDCl3) δ ppm: 5.86-5.87 (m, 2H), 5.15 (dd, J = 8.70 Hz and 6.30 Hz, 1H), 4.01-4.11 (m, 4H), 3.21 (dd, J = 16.80 Hz and 6.30 Hz, 1H), 3.10-3.18 (m, 2H), 2.88 (dd, J = 16.80 Hz and 8.70 Hz, 1H), 2.53-2.59 (m, 2H), 2.21-2.28 (m, 2H), 1.53-1.58 (m, 4H), 1.23-1.29 (m, 16H), 0.84-0.86 (m, 6H). 13C-NMR (CDCl3) δ ppm: 18.01, 23.34, 25.72, 28.60, 31.65, 33.31, 38.90, 48.88, 65.18, 66.29, 127.39, 127.48, 167.68, 169.92, 178.83. MS, m/z (%): 464 (35.0, M+ + 1), 347 (9.0), 249 (100.0), 221 (40.0), 204 (14.0), 177 (15.0), 79 (26.0), 57 (51.0), 43 (27.0). Anal. calcd for C26H41NO6: C 67.36, H 8.91, N 3.03; found C 67.82, H 9.14, N 3.78.
Dioctyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2g): Pale yellow oil; IR νmax(neat)/cm-1 2925, 1739, 1465, 973. 1H-NMR (CDCl3) δ ppm: 5.87 -5.89 (m, 2H), 5.17 (dd, , J = 8.70 Hz and 6.00 Hz, 1H), 4.02-4.12 (m, 4H), 3.23 (dd, J = 18.00 and 6.00 Hz, 1H), 3.11-3.17 (m, 2H), 2.90 (dd, J = 18.00 Hz, 8.70 Hz, 1H), 2.56-2.60 (m, 2H), 2.22-2.29 (m, 2H), 1.55-1.59 (m, 4H), 1.25-1.27 (m, 20H), 0.85-0.90 (m, 6H). 13C-NMR (CDCl3 ) δ ppm: 14.06, 22.61, 25.69, 25.81, 23.20, 25.75, 29.10, 31.74, 33.33, 38.90, 48.91, 65.25, 127.45, 167.70, 169.94, 178.84. MS, m/z (%): 492 (39.5, M+ + 1), 380 (5.0), 361 (8.0), 249 (100.0), 221 (36.0), 204 (12.5), 177 (13.0), 71 (21.0), 57 (23.5), 43 (29.9). Anal. calcd for C28H45NO6: C 68.91, H 9.23, N 2.85; found C 68.61, H 9.18, N 2.65.
Dinonyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2h): Yellow oil; IR νmax(neat)/cm-1 2925, 1745, 1450, 973. 1H-NMR (CDCl3) δ ppm: 5.83-5.88 (m, 2H), 5.12 (dd, J = 8.40 Hz and 6.20 Hz, 1H), 3.97-4.10 (m, 4H), 3.17 (dd, J = 16.70 Hz, 6.20 Hz, 1H), 3.00-3.06 (m, 2H), 2.87 (dd, J = 16.70 Hz and 8.40 Hz, 1H), 2.50-2.52 (m, 2H), 2.19-2.24 (m, 2H), 1.50-1.56 (m, 4H), 1.21-1.32 (m, 24H), 0.81-0.89 (m, 6H). 13C-NMR (CDCl3) δ ppm: 19.10, 23.34, 25.69, 25.89, 28.37, 29.14, 29.17, 31.61, 33.33, 38.90, 48.92, 65.18, 66.29, 127.40, 167.68, 169.91, 178.78. MS, m/z (%): 520 (17.0, M+ + 1), 305 (15.3), 249 (100.0), 221 (51.0), 203 (29.0), 177(26.0), 79(52.0), 57(40.0), 41(49.0).Anal. calcd for C30H49NO6: C 69.33, H 9.50, N 2.70; found C 69.74, H 9.12, N 2.91.
Didecyl 2-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)succinate (2i): Pale yellow oil; IR νmax(neat)/cm-1 2925, 1733, 1460, 979. 1H-NMR (CDCl3) δ ppm: 5.86-5.87 (m, 2H), 5.15 (dd, J = 8.40 Hz and 6.30 Hz, 1H), 4.01-4.11 (m, 4H), 3.21 (dd, J = 16.65 Hz and 6.30 Hz, 1H ), 3.07-3.09 (m, 2H), 2.89 (dd, J = 16.65 Hz and 8.40 Hz, 1H), 2.53-2.58 (m, 2H), 2.21-2.28 (m, 2H), 1.56-1.58 (m, 4H), 1.24-1.30 (m, 28H), 0.84-0.88 (m, 6H). 13C-NMR (CDCl3) δ ppm: 17.04, 21.15, 27.10, 28.47, 29.14, 29.40, 31.20, 31.84, 32.78, 33.32, 38.87, 48.91, 59.49, 62.98, 65.17, 66.27, 127.40, 167.66, 169.90, 178.79. MS, m/z (%): 548 (42.3, M+ + 1), 408 (6.6), 389 (8.0), 249 (100.0), 221 (31.5), 204 (11.0), 177 (13.0), 71 (19.0), 57 (33.0), 43 (37.0). Anal. calcd for C32H53NO6: C 70.17, H 9.75, N 2.56; found C 70.85, H 9.26, N 2.24.
Dipropyl 3-(3a,4,7,7a-tetrahydro-1,3-dioxo-1H-isoindol-2(3H)-yl)propanoate (3a): Colorless oil; IR νmax(neat)/cm-1 2949, 1727, 1447, 979. 1H-NMR (CDCl3) δ ppm: 5.75-5.76 (m, 2H). 3.93 (d, J = 6.6 Hz, 2H) 3.63 (t, J = 7.20 Hz, 2H), 2.96-2.98 (m, 2H), 2.41-2.48 (m, 4H), 2.10 (t, J = 7.20 Hz, 2H), 1.43-1.52 (m, 2H), 1.19-1.31 (m, 2H), 0.78-0.83 (m, 3H). 13C-NMR (CDCl3) δ ppm: 13.54, 18.95, 23.35, 30.41, 31.98, 34.46, 38.91, 64.50, 127.56, 170.51, 179.56. MS, m/z (%): 280 (18.0, M+ + 1), 279 (11.0), 205 (100.0), 177 (13.0), 163 (14.0), 99 (15.0), 79 (37.0), 55 (31.0). Anal. calcd for C15H21NO4: C 64.50, H 7.58, N 5.02; found C 64.87, H 7.85, N 5.61.
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MDPI and ACS Style

Imanzadeh, G.; Ahmadi, F.; Zamanloo, M.; Mansoori, Y. Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions. Molecules 2010, 15, 7353-7362. https://doi.org/10.3390/molecules15107353

AMA Style

Imanzadeh G, Ahmadi F, Zamanloo M, Mansoori Y. Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions. Molecules. 2010; 15(10):7353-7362. https://doi.org/10.3390/molecules15107353

Chicago/Turabian Style

Imanzadeh, Gholamhassan, Farzaneh Ahmadi, Mohammadreza Zamanloo, and Yagoub Mansoori. 2010. "Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions" Molecules 15, no. 10: 7353-7362. https://doi.org/10.3390/molecules15107353

APA Style

Imanzadeh, G., Ahmadi, F., Zamanloo, M., & Mansoori, Y. (2010). Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions. Molecules, 15(10), 7353-7362. https://doi.org/10.3390/molecules15107353

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