Next Article in Journal
Challenges and Opportunities of Implementing Data Fusion in Process Analytical Technology—A Review
Next Article in Special Issue
Lipase-Catalyzed Synthesis, Antioxidant Activity, Antimicrobial Properties and Molecular Docking Studies of Butyl Dihydrocaffeate
Previous Article in Journal
Classification of Polish Natural Bee Honeys Based on Their Chemical Composition
Previous Article in Special Issue
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 27
Issue 15
10.3390/molecules27154842
Review Report
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond

Molecules 2022, 27(15), 4842; https://doi.org/10.3390/molecules27154842
by Shuqin Liu 1,†, Xican Li 1,*,†, Ban Chen 1, Xiaojian Ouyang 1, Yulu Xie 1 and Dongfeng Chen 2,*
Reviewer 1:
Eun Ju Shin
Reviewer 2:
Mosad Ghareeb
Molecules 2022, 27(15), 4842; https://doi.org/10.3390/molecules27154842
Submission received: 7 July 2022 / Revised: 23 July 2022 / Accepted: 26 July 2022 / Published: 28 July 2022
(This article belongs to the Special Issue Chemistry, Biology, and Pharmacology of Natural Phenolic Compounds and Their Synthetic Derivatives)

Round 1

Reviewer 1 Report

This manuscript describes the radical-mediated dimerization reaction of 13 phytophenols and in situ product identification using UHPLC-ESI-Q-TOF-MS/MS. The authors found out four basic rules governing phytophenol dimerization reaction: meta-exclusion, C-C bonding domination, ortho-di-OH coactivation, and exocyclic C=C bond involvement. This study was systematically described and presented reasonable conclusions from the comparison of MS data between reaction products and authentic samples. However, it is recommended to provide supporting evidence by isolating the dimerization reaction products of at least one of the 13 phytophenols and confirming their structures with other spectroscopic data. Also, please, change disassociation(p 2  line 88) to dissociation. This paper is recommended for publication in Molecules.

Author Response

Please kindly see the attached pdf file.

Author Response File: Author Response.pdf

Reviewer 2 Report

Review comments to the author

Title: ''Phytophenol Dimerization Reaction: from Basic Rules to Diastereoselectivity and Beyond''.

 

Manuscript ID: molecules-1829639.

Introduction:

1- Page 1, Line 38: The citations [2], [3] should be written as [2, 3]. Please, apply this concept for all coming citations.

2- Page 2, Line 54: Add one space before the citation [6, 7]. Please, apply this concept for all coming citations.

Results and discussion:

1- Page 4, Line 143, Table 1: The title of the first column should be written as ''Phytophenol probe''. 

2- Page 5, Line 192: Add one space after the citation [19-21].

3- Page 5, Line 196: Add one space before the citation [11].

4- Page 5, Line 166-177: This section should be reinforced by relevant citations.

Abbreviations:

- List of abbreviations should be inserted by the end of the manuscript before references.

 

References:

1- Page 8, Line 338: The species names ''Bacillus megaterium'' and ''Curvularia lunata'' should be written in italic font. 

 

Supplementary Materials:   

Chemicals and reagents

1- It is necessary to add a new section containing all the chemicals and reagents used and their sources (Company name, city and country).

 

Author Response

Please kindly see the attached.

Author Response File: Author Response.pdf

Back to TopTop