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Article

Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations

1
Department of Chemistry and Innovation Center of Pesticide Research, College of Science, China Agricultural University, Beijing 100193, China
2
Department of Nutrition and Health, China Agricultural University, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(19), 6789; https://doi.org/10.3390/molecules28196789
Submission received: 5 September 2023 / Revised: 19 September 2023 / Accepted: 20 September 2023 / Published: 24 September 2023
(This article belongs to the Section Organic Chemistry)

Abstract

:
Iodine is a well-known oxidant that is widely used in organic syntheses. Thiol oxidation by stoichiometric iodine is one of the most commonly employed strategies for the synthesis of valuable disulfides. While recent advancements in catalytic aerobic oxidation conditions have eliminated the need for stoichiometric oxidants, concerns persist regarding the use of toxic or expensive catalysts. In this study, we discovered that iodine can be used as a cheap, low-toxicity catalyst in the aerobic oxidation of thiols. In the catalytic cycle, iodine can be regenerated via HI oxidation by O2 at 70 °C in EtOAc. This protocol harnesses sustainable oxygen as the terminal oxidant, enabling the conversion of primary and secondary thiols with remarkable efficiency. Notably, all 26 tested thiols, encompassing various sensitive functional groups, were successfully converted into their corresponding disulfides with yields ranging from >66% to 98% at a catalyst loading of 5 mol%.

1. Introduction

Disulfide bonds are a valuable functional group known for their remarkable biological significance. They are widely prevalent in various natural compounds, biological formulations, biomaterials, and pharmaceuticals in Figure 1 [1,2,3,4,5,6]. The oxidation of thiols offers a straightforward and viable approach for synthesizing disulfides. Traditionally, thiol oxidation has entailed the use of various stoichiometric oxidizing agents, including iodine, hydrogen peroxide, metal salts or metal oxides [7,8], halogens [9,10], high-valent sulfur oxidants [11,12,13], diethyl azodicarboxylate [14], etc. To avoid the use of stoichiometric oxidants, chemists are increasingly exploring catalytic oxidation methodologies that utilize oxygen [6]. Despite the fact that oxygen is attractive due to its natural abundance, cost-effectiveness, and eco-friendliness, its relatively low reactivity poses a challenge to its application in thiol oxidation [15,16,17,18]. As a result, various transition metal catalysts and organic catalysts have been developed for the aerobic oxidation of thiols. Transition metal catalysts used always contain organic ligands such as Co (II) phthalocyanines [19], Mn(III) Schiff-base complex [20], CoSalen [21], and Fe(Pc) [22]. Meanwhile, organic catalysts like tert-butyl nitrite [23], diisopropylamine [24], and TEMPO [25] suffer from difficulties in oxidizing secondary thiols. Recently, non-metallic inorganic catalysts like SiO2-Cl have also been developed, while the tedious preparation process has limited their applications [26].
Herein, we have established a novel I2-catalyzed aerobic oxidative thiol coupling strategy. I2, due to its readily available and low toxicity attributes, emerges as a highly suitable catalyst within environmentally benign processes [27,28,29,30]. The oxidation of thiols to disulfides using iodine has demonstrated a wide range of reactive groups tolerated [31]. Additionally, iodine has previously been employed as a catalyst in thiol oxidation combined with additives like DMSO, H2O2, and flavin [32,33,34]. This study showcases its effectiveness as a catalyst in catalyzing aerobic thiol oxidation at elevated temperatures using only 5 mol% of iodine, which is more cost-effective and environmentally friendly compared to previous studies. Notably, this green protocol exhibits good tolerance toward a diverse array of primary and secondary thiols bearing various functional groups.

2. Results and Discussion

This study commenced with reaction condition optimization of the iodine-catalyzed aerobic oxidation of thiols (Table 1). Dodecane-1-thiol 1a was selected as the model substrate. The initial trial of the aerobic oxidation with 10 mol% I2 gave 2a in >98% yield at 70 °C in EtOAc (Entry 1, Table 1). The high yield of 2a was maintained when the amount of I2 was reduced to 5.0 mol% (Entry 2, Table 1). However, decreasing the catalyst loading of I2 to 1.0 mol% resulted in an incomplete conversion of 1a (Entry 3, Table 1). The influence of reaction duration was investigated. Decreasing the reaction time from 4 h to 1 h resulted in a reduction in the reaction yield from >98% to 49%, which indicated extending the reaction time to 4 h can ensure the complete conversion of 1a to 2a (Entry 4, Table 1). Following the determination of optimal catalyst loading and reaction time, the impact of varying solvents on the reaction was explored. Substituting EtOAc with dichloromethane or N,N-dimethylformamide resulted in notably diminished yields (Entries 5 and 6, Table 1). This observation indicates the solvent’s pronounced influence on this catalytic reaction. Subsequently, the impact of temperature was examined. The findings revealed that the reaction conducted at room temperature (r.t.) yielded 53% of 2a (Entry 7, Table 1), whereas the reaction conducted at 70 °C exhibited a significantly higher yield of >98%. Therefore, the optimal temperature for the experimental reaction was established at 70 °C. Finally, a control reaction with no catalyst was conducted. Significantly, only a trace amount of 2a was formed in the control reaction, providing compelling evidence that I2 serves as an indispensable element for the synthesis of disulfide 2a (Entry 8, Table 1).
Based on the comprehensive investigation of reaction conditions, we concluded that 5.0 mol% of I2 in EtOAc at 70 °C for a duration of 4 h was suitable for the substrate scope investigation (Figure 2). The substrate scope demonstrated that the I2-catalyzed aerobic oxidation protocol can convert all 23 tested primary and secondary thiols into disulfides in good to excellent yields. Notably, the aerobic oxidation process demonstrated a notable capacity to overcome the inherent challenges typically associated with secondary thiols, as exemplified by the good efficacy observed in the transformation of 1d to 2d. A variety of thiols with various functional groups were tested for the synthesis of symmetrical disulfides. Aryl thiols bearing both electron-withdrawing groups, including fluoride (2e, 2j), chloride (2f, 2g, and 2k), and bromide (2l, 2m, and 2n), as well as electron-donating functional groups such as methoxyl (2o, 2p, and 2q), isopropyl (2r), methyl (2s), and amide (2t), afforded the corresponding disulfides in good to excellent yields. Extending the scope beyond the aforementioned substrates, the protocol effectively facilitated the conversion of ploy-aromatic (2u) and heteroaromatic (2v and 2w) thiols into their respective disulfides. To underscore the practical utility of this approach, we have employed it in the oxidation of bioactive thiols, namely N-(tert-butoxycarbonyl)-L-cysteine methyl ester 1x and N-acetyl-L-cystine 1y (Figure 3), which have been used as treatments for acute paracetamol toxicity and peptide synthesis, respectively [35,36]. This resulted in the formation of the corresponding disulfides 2x and 2y in 66% and 98% yields, respectively. In addition, this method has also been applied to the oxidation of dithiol, dithiothreitol 1z (Figure 4). The exclusive formation of the cyclized disulfide 2z was achieved with an impressive yield of 98%, and there was no observed formation of the dimerized by-product. Notably, the formed trans-4,5-dihydroxy-1,2-dithiane 2z is an inducer of ER stress proteins, which protects the kidney from chemical stress in vivo [37]. These results not only emphasize the method’s effectiveness but also highlight its potential for synthesizing intricate bioactive disulfides.
In order to explore the possible mechanism of this reaction, a series of control reactions was conducted in Scheme 1. In the control reaction using 5 mol% HI to replace 5 mol% I2, 2a was also formed in >98% yield (Scheme 1(AI)). This result indicated that the catalyst iodine was regenerated from the oxidation of HI by oxygen. In the presence of TEMPO, a powerful free radical scavenger, the oxidation of thiols by stoichiometric iodine remained unaffected (Scheme 1(AII,AIII)). Interestingly, TEMPO completely halted the iodine-catalyzed aerobic oxidation of thiols (Scheme 1(AIV)). This observation strongly suggests that the oxidation of thiols might follow a distinct pathway within the catalytic cycle, contrasting with the oxidation process involving stoichiometric iodine.

3. Materials and Methods

3.1. General Information

Reagents and solvents were purchased from commercial suppliers and used directly without further purification, unless otherwise noted. All water was deionized before use. Unless otherwise noted, the glassware employed in the reactions was dried in an oven overnight before use. The oxygen purity used in the experiment is 99.999%.
NMR data were measured with a Bruker Avance NOE 500 and manipulated directly from the spectrometer or via a networked PC with appropriate software. Reference values for residual solvent were taken as δ = 7.27 (CDCl3) and δ = 2.50 (DMSO-d6) for 1H NMR; δ = 77.1 (CDCl3) and δ = 39.5 (DMSO-d6) for 13C{1H} NMR. Multiplicities for coupled signals were designated using the following abbreviations: s = singlet, d = doublet, t = triplet, q = quartet, quin = quintet, br = broad signal, and are given in Hz. Thin-layer chromatography was performed on SIL G/UV254 silica-glass plates, and the plates were visualized using ultra-violet light (254 nm) and KMnO4 solution. For flash column chromatography, silica gel (60, 35–70 μm) was used.

3.2. Calculation of the Yield by Internal Standard Using 1H NMR

The determination of yields by 1H NMR was according to the equation below:
Yield = Area product Area internal   standard n internal   standard n theoretical   product × 100 %
Areaproduct means the integration of the product peak; Areainternal standard means the integration of the internal standard peak; ninternal standard means the number of moles of the internal standard; ntheoretical product means the theoretical number of moles of the product.

3.3. Optimization Studies for the Oxidative Coupling of Thiols (Table 1)

To a round bottom flask were added I2 (0–7.61 mg, 0–10.0 mol%), dodecane-1-thiol (60.7 mg, 0.300 mmol, 1.00 equiv), and anhydrous EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 1–4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated. The crude product was purified by flash chromatography (silica, 0–12.5% EtOAc/Hexane). The sample was then analyzed by 1H NMR (CDCl3, 500 MHz) to obtain the yield using the internal standard (1,1,2,2-tetrachloroethane) and comparison with corresponding samples.

3.4. General Procedure for the Oxidative Coupling of Thiols

To a round bottom flask were added I2 (3.81 mg, 5.00 mol%), thiol (0.300 mmol, 1.00 equiv), and EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated to give the crude product. The crude product was purified by flash chromatography (silica, 0–12.5% EtOAc/Hexane). Notably, 1H NMR and 13C{1H} NMR data of 2a2z were presented at Supporting Information.
  • 1,2-Didodecyldisulfane (2a) [38]. According to the general procedure, the oxidation of dodecane-1-thiol (60.7 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane), afforded 59.2 mg of 2a in 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 2.68 (t, J = 7.4 Hz, 4H), 1.67 (m, 4H), 1.38 (m, 4H), 1.31–1.22 (m, 32H), 0.88 (t, J = 6.9 Hz, 6H); 13C{1H} NMR (126 MHz, CDCl3) δ 39.3, 32.0, 29.7 (×3), 29.6, 29.4, 29.3 (×2), 28.6, 22.8, 14.2.
  • 1,2-Diphenethyldisulfane (2b) [39]. According to the general procedure, the oxidation of 2-phenylethane-1-thiol (41.5 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 40.3 mg of 2b in 98% yield as a yellow oil. 1H NMR (500 MHz, CDCl3) δ 7.29 (m, 4H), 7.23–7.16 (m, 6H), 3.01–2.95 (m, 4H), 2.95–2.90 (m, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 140.1, 128.7, 128.6, 126.5, 40.3, 35.8.
  • 1,2-Dibenzyldisulfane (2c) [40]. According to the general procedure, the oxidation of phenylmethanethiol (37.3 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa), after chromatography (0–10% EtOAc/Hexane), afforded 36.2 mg of 2c in a 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.33–7.28 (m, 4H), 7.28–7.25 (m, 2H), 7.25–7.21 (m, 4H), 3.59 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 137.4, 129.5, 128.6, 127.5, 43.4.
  • 1,2-Dicyclohexyldisulfane (2d) [41]. According to the general procedure, the oxidation of cyclohexanethiol (34.9 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 33.9 mg of 2d in 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 2.68 (m, 2H), 2.12–1.94 (m, 4H), 1.86–1.71 (m, 4H), 1.67–1.52 (m, 2H), 1.39–1.16 (m, 10H); 13C{1H} NMR (126 MHz, CDCl3) δ 50.1, 32.9, 26.2, 25.8.
  • 1,2-Bis(4-fluorobenzyl)disulfane (2e) [42]. According to the general procedure, the oxidation of (4-fluorophenyl)methanethiol (42.6 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 41.5 mg of 2e in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.19 (m, 4H), 7.01 (m, 4H), 3.58 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 162.3 (d, JC-F = 246.4 Hz), 133.2 (d, JC-F = 3.1 Hz), 131.0 (d, J C-F= 8.1 Hz), 115.5 (d, JC-F= 21.5 Hz), 42.5.
  • 1,2-Bis(4-chlorobenzyl)disulfane (2f) [43]. According to the general procedure, the oxidation of (4-chlorophenyl)methanethiol (47.6 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 46.3 mg of 2f in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.29 (m, 4H), 7.15 (m, 4H), 3.57 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 135.9, 133.5, 130.7, 128.7, 42.6.
  • 1,2-Bis(2-chlorobenzyl)disulfane (2g) [38]. According to the general procedure, the oxidation of (2-chlorophenyl)methanethiol (47.6 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 46.3 mg of 2g in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.37 (m, 2H), 7.26 (m, 2H), 7.24–7.20 (m, 4H), 3.78 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 135.1, 134.2, 131.7, 129.8, 129.0, 126.8, 41.2.
  • 1,2-Bis(4-methoxybenzyl)disulfane (2h) [38]. According to the general procedure, the oxidation of (4-methoxyphenyl)methanethiol (46.3 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 45.0 mg of 2h in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.16 (m, 4H), 6.85 (m, 4H), 3.79 (s, 6H), 3.59 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 159.1, 130.6, 129.5, 114.0, 55.3, 42.8.
  • 1,2-Bis(4-(tert-butyl)benzyl)disulfane (2i) [42]. According to the general procedure, the oxidation of (4-(tert-butyl)phenyl)methanethiol (54.1 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 52.7 mg of 2i in 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.33 (m, 4H), 7.17 (m, 4H), 3.59 (s, 4H), 1.31 (s, 18H); 13C{1H} NMR (126 MHz, CDCl3) δ 150.5, 134.3, 129.2, 125.5, 43.1, 34.6, 31.4.
  • 1,2-Bis(4-fluorophenyl)disulfane (2j) [40]. According to the general procedure, the oxidation of 4-fluorobenzenethiol (38.4 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 37.4 mg of 2j in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.43 (m, 4H), 7.00 (m, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 162.7 (d, JC-F = 247.8 Hz), 132.3 (d, JC-F = 3.2 Hz), 131.4 (d, JC-F = 8.1 Hz), 116.4 (d, JC-F = 22.5 Hz).
  • 1,2-Bis(4-chlorophenyl)disulfane (2k) [40]. According to the general procedure, the oxidation of 4-chlorobenzenethiol (43.4 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 42.2 mg of 2k in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.39 (m, 4H), 7.27 (m, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 135.2, 133.7, 129.4 (×2).
  • 1,2-Bis(4-bromophenyl)disulfane (2l) [40]. According to the general procedure, the oxidation of 4-bromobenzenethiol (56.7 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 47.4 mg of 2l in 84% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.41 (m, 4H), 7.32 (m, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 135.8, 132.3, 129.4, 121.6.
  • 1,2-Bis(3-bromophenyl)disulfane (2m) [39]. According to the general procedure, the oxidation of 3-bromobenzenethiol (56.7 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 55.3 mg of 2m in a 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.62 (m, 2H), 7.41–7.33 (m, 4H), 7.17 (m, 2H); 13C{1H} NMR (126 MHz, CDCl3) δ 138.7, 130.6, 130.5, 130.0, 126.0, 123.2.
  • 1,2-Bis(2-bromophenyl)disulfane (2n) [41]. According to the general procedure, the oxidation of 2-bromobenzenethiol (56.7 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 53.6 mg of 2n in a 95% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.55–7.50 (m, 4H), 7.26 (m, 2H), 7.07 (m, 2H); 13C{1H} NMR (126 MHz, CDCl3) δ 136.2, 133.0, 128.3, 128.0, 127.0, 121.1.
  • 1,2-Bis(4-methoxyphenyl)disulfane (2o) [40]. According to the general procedure, the oxidation of 4-methoxybenzenethiol (42.1 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 40.9 mg of 2o in 98% yield as a yellow oil. 1H NMR (500 MHz, CDCl3) δ 7.39 (m, 4H), 6.83 (m, 4H), 3.79 (s, 6H); 13C{1H} NMR (126 MHz, CDCl3) δ 160.0, 132.7, 128.5, 114.7, 55.4.
  • 1,2-Bis(2-methoxyphenyl)disulfane (2p) [40]. According to the general procedure, the oxidation of 2-methoxybenzenethiol (42.1 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane), afforded 40.9 mg of 2p in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.53 (m, 2H), 7.17 (m, 2H), 6.90 (m, 2H), 6.84 (m, 2H), 3.88 (s, 6H); 13C{1H} NMR (126 MHz, CDCl3) δ 156.7, 127.8, 127.7, 124.6, 121.4, 110.6, 55.9.
  • 1,2-Bis(3,4-dimethoxyphenyl)disulfane (2q) [40]. According to the general procedure, the oxidation of 3,4-dimethoxybenzenethiol (51.1 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 49.8 mg of 2q in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.06 (d, J = 2.1 Hz, 1H), 7.04 (d, J = 2.1 Hz, 1H), 7.01 (m, 2H), 6.79 (s, 1H), 6.78 (s, 1H), 3.87 (s, 6H), 3.83 (s, 6H); 13C{1H} NMR (126 MHz, CDCl3) δ 149.6, 149.2, 128.7, 123.9, 114.1, 111.3, 56.0, 55.9.
  • 1,2-Bis(4-isopropylphenyl)disulfane (2r) [44]. According to the general procedure, the oxidation of 4-isopropylbenzenethiol (45.6 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 39.0 mg of 2r in 86% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.42 (m, 4H), 7.16 (m, 4H), 2.87 (m, 2H), 1.22 (d, J = 6.9 Hz, 12H); 13C{1H} NMR (126 MHz, CDCl3) δ 148.4, 134.4, 128.3, 127.3, 33.8, 24.0.
  • 1,2-Di-p-tolyldisulfane (2s) [40]. According to the general procedure, the oxidation of 4-methylbenzenethiol (37.3 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 32.2 mg of 2s in 87% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.38 (m, 4H), 7.10 (m, 4H), 2.32 (s, 6H); 13C{1H} NMR (126 MHz, CDCl3) δ 137.5, 134.0, 129.9, 128.6, 21.1.
  • N,N′-(Disulfanediylbis(4,1-phenylene))diacetamide (2t) [41]. According to the general procedure, the oxidation of N-(4-mercaptophenyl)acetamide (50.2 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–10% MeOH/EtOAc) afforded 40.4 mg of 2t in 81% yield as a white solid. 1H NMR (500 MHz, DMSO-d6) δ 10.07 (s, 2H), 7.59 (m, 4H), 7.42 (m, 4H), 2.04 (s, 6H); 13C{1H} NMR (126 MHz, DMSO-d6) δ 168.5, 139.5, 130.1, 129.4, 119.7, 24.0.
  • 1,2-Di(naphthalen-2-yl)disulfane (2u) [40]. According to the general procedure, the oxidation of naphthalene-2-thiol (48.1 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 46.8 mg of 2u in 98% yield as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.97 (m, 2H), 7.79–7.74 (m, 4H), 7.71 (m, 2H), 7.61 (m, 2H), 7.48–7.40 (m, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 134.3, 133.6, 132.6, 129.1, 127.8, 127.5, 126.8, 126.6, 126.3, 125.7.
  • 1,2-Di(thiophen-2-yl)disulfane (2v) [41]. According to the general procedure, the oxidation of thiophene-2-thiol (34.9 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (100% Hexane) afforded 28.3 mg of 2v in 82% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.48 (d, J = 5.2 Hz, 2H), 7.14 (d, J = 3.7 Hz, 2H), 7.00 (dd, J = 5.2, 3.7 Hz, 2H); 13C{1H} NMR (126 MHz, CDCl3) δ 135.8, 135.7, 132.3, 127.8.
  • 1,2-Bis(furan-2-ylmethyl)disulfane (2w) [39]. According to the general procedure, the oxidation of furan-2-ylmethanethiol (34.2 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–12.5% EtOAc/Hexane) afforded 33.3 mg of 2w in 98% yield as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.38 (m, 2H), 6.33 (dd, J = 3.2, 2.0 Hz, 2H), 6.22 (d, J = 3.2 Hz, 2H), 3.68 (s, 4H); 13C{1H} NMR (126 MHz, CDCl3) δ 150.3, 142.5, 110.8, 109.0, 35.7.
  • Dimethyl 3,3′-disulfanediyl(2R,2′R)-bis(2-((tert-butoxycarbonyl)amino)propanoate) (2x) [45]. According to the general procedure, the oxidation of N-(tert-butoxycarbonyl)-L-cysteine methyl ester (70.6 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–30% EtOAc/Hexane) afforded 46.4 mg of 2y in 66% yield as a white solid. 1H NMR (500 MHz, DMSO-d6) δ 7.36 (d, J = 8.2 Hz, 2H), 4.26 (m, 2H), 3.64 (s, 6H), 3.07 (m, 2H), 2.90 (m, 2H), 1.37 (s, 18H); 13C{1H} NMR (126 MHz, CDCl3) δ 171.4, 155.3, 78.6, 52.7, 52.1, 39.1, 28.1.
  • (2R,2′R)-3,3′-disulfanediylbis(2-acetamidopropanoic acid) (2y) [20]. According to the general procedure, the oxidation of N-acetyl-L-cysteine (49.0 mg, 0.300 mmol) is catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa). The reaction mixture was concentrated, then washed with EtOAc (20 mL), affording 47.7 mg of 2z in 98% yield as a white solid. 1H NMR (500 MHz, D2O) δ 4.68 (dd, J = 8.6, 4.3 Hz, 2H), 3.38 (dd, J = 14.1, 4.3 Hz, 2H), 3.02 (dd, J = 14.1, 8.6 Hz, 2H), 2.04 (s, 6H); 13C{1H} NMR (126 MHz, D2O) δ 177.7, 174.1, 53.2, 39.4, 21.8.
  • (4R,5R)-1,2-Dithiane-4,5-diol (2z) [46]. According to the general procedure, the oxidation of (2R,3R)-1,4-dimercaptobutane-2,3-diol (46.3 mg, 0.300 mmol) catalyzed by I2 (3.81 mg, 5.00 mol%) under an oxygen balloon (0.3 MPa) after chromatography (0–100% EtOAc/Hexane) afforded 44.8 mg of 2z in 98% yield as a white solid. 1H NMR (500 MHz, CD3OD) δ 3.48–3.31 (m, 2H), 3.02–2.89 (m, 2H), 2.84–2.73 (m, 2H); 13C{1H} NMR (126 MHz, CD3OD) δ 74.09, 40.4.

3.5. Procedure for Control Experiments (Scheme 1)

Scheme 1(AI): To a round bottom flask were added 55 wt% HI (3.49 mg, 5.00 mol%), dodecane-1-thiol (60.7 mg, 0.300 mmol, 1.00 equiv), and anhydrous EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated. The crude product was then analyzed by 1H NMR (CDCl3, 500 MHz) to obtain the yield using the internal standard (1,1,2,2-tetrachloroethane) and comparison with corresponding samples.
Scheme 1(AII): To a round bottom flask were added I2 (38.1mg, 50.0 mol%), dodecane-1-thiol (60.7 mg, 0.300 mmol, 1.00 equiv), and anhydrous EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated. The crude product was then analyzed by 1H NMR (CDCl3, 500 MHz) to obtain the yield using the internal standard (1,1,2,2-tetrachloroethane) and comparison with corresponding samples.
Scheme 1(AIII): To a round bottom flask were added I2 (38.1 mg, 50.0 mol%), dodecane-1-thiol (60.7 mg, 0.300 mmol, 1.00 equiv), TEMPO (1.00 equiv), and anhydrous EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated. The crude product was then analyzed by 1H NMR (CDCl3, 500 MHz) to obtain the yield using the internal standard (1,1,2,2-tetrachloroethane) and comparison with the corresponding sample.
Scheme 1(AIV): To a round bottom flask were added I2 (3.81 mg, 5.00 mol%), dodecane-1-thiol (60.7 mg, 0.300 mmol, 1.00 equiv), TEMPO (1.00 equiv), and anhydrous EtOAc (8.00 mL). The flask was filled with an oxygen balloon (0.3 MPa), and the reaction mixture was stirred at 70 °C for a duration of 4 h. Subsequently, the reaction mixture was cooled to r.t. The reaction mixture was diluted with EtOAc (10.0 mL) and washed with HCl solution (15.0 mL, 0.100 M, aq). The aqueous layer was extracted with EtOAc (3 × 15.0 mL). Organic layers were combined, dried over MgSO4, filtered, and concentrated. The crude product was then analyzed by 1H NMR (CDCl3, 500 MHz) to obtain the yield using the internal standard (1,1,2,2-tetrachloroethane) and comparison with corresponding samples.

4. Conclusions

In summary, we have established a cost-effective and environmentally friendly I2-catalyzed aerobic oxidative coupling of thiols for the synthesis of valuable disulfide. In contrast to reported catalytic aerobic oxidation methods, this protocol circumvented the need for transition-metal catalysts and reagents that are not commercially available. This novel method tolerates both primary and secondary alkyl thiols, as well as aryl thiols. All 26 tested substrates with various functional groups resulted in good yields, which highlighted the exceptional functional group compatibility of this approach. This sustainable methodology holds promise for widespread applicability across both academic and industrial realms.

Supplementary Materials

The following supporting information, including 1H NMR and 13C{1H} NMR data of 2a2z can be downloaded at: https://www.mdpi.com/article/10.3390/molecules28196789/s1.

Author Contributions

Conceptualization, J.A.; Synthesis, L.W., Z.Q., X.L., Z.Y. and Z.K.; NMR (Nuclear Magnetic Resonance), L.W. and L.C.; methodology, J.A., H.D. and L.W.; writing—original draft preparation, L.W., L.C., X.Q. and K.N.; writing—review and editing, J.A. and H.D. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the National Key Research and Development Program of China (2022YFF0710402) and Beijing Qi Dian Shi Neng Technology Co., Ltd. for support.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

Sample Availability

Data on the compounds are available from the authors.

References

  1. Eom, T.; Khan, A. Disulfides as Mercapto-Precursors in Nucleophilic Ring Opening Reaction of Polymeric Epoxides: Establishing Equimolar Stoichiometric Conditions in a Thiol–Epoxy ‘Click’ Reaction. Chem. Commun. 2020, 56, 7419–7422. [Google Scholar] [CrossRef]
  2. Yang, S.; Yu, X.; Szostak, M. Divergent Acyl and Decarbonylative Liebeskind−Srogl Cross-Coupling of Thioesters by Cu-Cofactor and Pd–NHC (NHC = N-Heterocyclic Carbene) Catalysis. ACS Catal. 2023, 13, 1848–1855. [Google Scholar] [CrossRef]
  3. Zhang, R.; Nie, T.; Fang, Y.; Huang, H.; Wu, J. Poly(Disulfide)s: From Synthesis to Drug Delivery. Biomacromolecules 2022, 23, 1–19. [Google Scholar] [CrossRef]
  4. Li, H.; Peng, M.; Li, J.; Do, H.; Ni, K.; Wang, M.; Yuan, Z.; Wang, L.; Zhao, T.; Zhang, X.; et al. Redox-Click Chemistry for Disulfide Formation from Thiols 2023. Available online: https://chemrxiv.org/engage/chemrxiv/article-details/6442481be4bbbe4bbf0117ad (accessed on 4 September 2023).
  5. Hou, X.; Li, Y.; Pan, Y.; Jin, Y.; Xiao, H. Controlled Release of Agrochemicals and Heavy Metal Ion Capture Dual-Functional Redox-Responsive Hydrogel for Soil Remediation. Chem. Commun. 2018, 54, 13714–13717. [Google Scholar] [CrossRef]
  6. Wang, M.; Jiang, X. Sulfur–Sulfur Bond Construction. Top. Curr. Chem. 2018, 376, 14. [Google Scholar] [CrossRef] [PubMed]
  7. Heravi, M.M.; Derikvand, F.; Oskooie, H.A.; Shoar, R.H.; Tajbakhsh, M. Silica-Supported Bis (Trimethylsilyl) Chromate: Oxidation of Thiols to Their Corresponding Disulfides. Synth. Commun. 2007, 37, 513–517. [Google Scholar] [CrossRef]
  8. Lenardão, E.J.; Silva, M.S.; Mendes, S.R.; de Azambuja, F.; Jacob, R.G.; Santos, P.C.S.d.; Perin, G. Synthesis of Beta-Phenylchalcogeno-Alpha, Beta-Unsaturated Esters, Ketones and Nitriles Using Microwave and Solvent-Free Conditions. J. Braz. Chem. Soc. 2007, 18, 943–950. [Google Scholar] [CrossRef]
  9. Bourles, E.; de Sousa, R.A.; Galardon, E.; Selkti, M.; Tomas, A.; Artaud, I. Cyclic Mono & Bis-Disulfide & Selective Conversion to Mono- and Bis-Thiosulfinate. Tetrahedron 2007, 63, 2466–2471. [Google Scholar]
  10. Ali, M.H.; McDermott, M. Oxidation of Thiols to Disulfides with Molecular Bromine on Hydrated Silica Gel Support. Tetrahedron Lett. 2002, 43, 6271–6273. [Google Scholar] [CrossRef]
  11. Karimi, B.; Zareyee, D. Hexamethyldisilazane (HMDS) Promotes Highly Efficient Oxidative Coupling of Thiols by DMSO Under Nearly Neutral Reaction Conditions. Synlett 2002, 2, 0346–0348. [Google Scholar] [CrossRef]
  12. Leino, R.; Lönnqvist, J.E. A Very Simple Method for the Preparation of Symmetrical Disulfides. Tetrahedron. Lett. 2004, 45, 8489–8491. [Google Scholar] [CrossRef]
  13. Hajipour, A.R.; Mallakpour, S.E.; Adibi, H. Selective and Efficient Oxidation of Sulfides and Thiols with Benzyltriphenylphosphonium Peroxymonosulfate in Aprotic Solvent. J. Org. Chem. 2002, 67, 8666–8668. [Google Scholar] [CrossRef] [PubMed]
  14. Harusawa, S.; Yoshida, K.; Kojima, C.; Araki, L.; Kurihara, T. Design and Synthesis of an Aminobenzo-15-Crown-5-Labeled Estradiol Tethered with Disulfide Linkage. Tetrahedron 2004, 60, 11911–11922. [Google Scholar] [CrossRef]
  15. Dou, Y.; Huang, X.; Wang, H.; Yang, L.; Li, H.; Yuan, B.; Yang, G. Reusable Cobalt-Phthalocyanine in Water: Efficient Catalytic Aerobic Oxidative Coupling of Thiols to Construct S–N/S–S Bonds. Green Chem. 2017, 19, 2491–2495. [Google Scholar] [CrossRef]
  16. Shi, Z.; Zhang, C.; Tang, C.; Jiao, N. Recent Advances in Transition-Metal Catalyzed Reactions Using Molecular Oxygen as the Oxidant. Chem. Soc. Rev. 2012, 41, 3381–3430. [Google Scholar] [CrossRef]
  17. Punniyamurthy, T.; Velusamy, S.; Iqbal, J. Recent Advances in Transition Metal Catalyzed Oxidation of Organic Substrates with Molecular Oxygen. Chem. Rev. 2005, 105, 2329–2364. [Google Scholar] [CrossRef] [PubMed]
  18. Obora, Y.; Ishii, Y. Palladium-Catalyzed Intermolecular Oxidative Amination of Alkenes with Amines, Using Molecular Oxygen as Terminal Oxidant. Catalysts 2013, 3, 794–810. [Google Scholar] [CrossRef]
  19. Chauhan, S.M.S.; Kumar, A.; Srinivas, K.A. Oxidation of Thiols with Molecular Oxygen Catalyzed by Cobalt(II) Phthalocyanines in Ionic Liquid. Chem. Commun. 2003, 18, 2348–2349. [Google Scholar] [CrossRef]
  20. Oba, M.; Tanaka, K.; Nishiyama, K.; Ando, W. Aerobic Oxidation of Thiols to Disulfides Catalyzed by Diaryl Tellurides under Photosensitized Conditions. J. Org. Chem. 2011, 76, 4173–4177. [Google Scholar] [CrossRef] [PubMed]
  21. Tan, C.X.; Pan, L.Y.; Zhang, G.F.; Li, Y.S. A Facile Oxidation of Thiols to Disulfides Catalyzed by CoSalen. Phosphorus Sulfur Silicon Relat. Elem. 2012, 187, 16–21. [Google Scholar] [CrossRef]
  22. Huang, H.; Ash, J.; Kang, J.Y. Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S–S and S–P(O) Bonds. Org. Biomol. Chem. 2018, 16, 4236–4242. [Google Scholar] [CrossRef] [PubMed]
  23. Yi, S.L.; Li, M.C.; Hu, X.Q.; Mo, W.-M.; Shen, Z.-L. An Efficient and Convenient Method for the Preparation of Disulfides from Thiols Using Oxygen as Oxidant Catalyzed by Tert-Butyl Nitrite. Chin. Chem Lett. 2016, 27, 1505–1508. [Google Scholar] [CrossRef]
  24. Kuciński, K.; Hreczycho, G. Diisopropylamine as a Single Catalyst in the Synthesis of Aryl Disulfides. Green Process. Synth. 2018, 7, 12–15. [Google Scholar] [CrossRef]
  25. Yang, L.; Li, S.; Dou, Y.; Zhen, S.; Li, H.; Zhang, P.; Yuan, B.; Yang, G. TEMPO-Catalyzed Aerobic Oxidative Coupling of Thiols for Metal-Free Formation of S−N/S−S Bonds. Asian J. Org. Chem. 2017, 6, 265–268. [Google Scholar] [CrossRef]
  26. Sathe, M.; Ghorpade, R.; Kaushik, M.P. Oxidation of Thiols to Disulfides Using Silica Chloride as a Heterogeneous Catalyst. Chem. Lett. 2006, 35, 1048–1049. [Google Scholar] [CrossRef]
  27. Breugst, M.; von der Heiden, D. Mechanisms in Iodine Catalysis. Chem. Eur. J. 2018, 24, 9187–9199. [Google Scholar] [CrossRef]
  28. Breugst, M.; Detmar, E.; von der Heiden, D. Origin of the Catalytic Effects of Molecular Iodine: A Computational Analysis. ACS Catal. 2016, 6, 3203–3212. [Google Scholar] [CrossRef]
  29. Li, Y.X.; Wang, H.X.; Ali, S.; Xia, X.F.; Liang, Y.M. Iodine-Mediated Regioselective C2-Amination of Indoles and a Concise Total Synthesis of (±)-Folicanthine. Chem. Commun. 2012, 48, 2343–2345. [Google Scholar] [CrossRef]
  30. Ishihara, K.; Muñiz, K. Iodine Catalysis in Organic Synthesis; Wiley-VCH: Weinheim, Germany, 2022; pp. 11–22. [Google Scholar]
  31. Witt, D. Recent developments in disulfide bond formation. Synthesis 2008, 16, 2491–2509. [Google Scholar] [CrossRef]
  32. Bettanin, L.; Saba, S.; Galetto, F.Z.; Mike, G.A.; Rafique, J.; Braga, A.L. Solvent and metal-free selective oxidation of thiols to disulfides using I2/DMSO catalytic system. Tetrahedron. Lett. 2017, 58, 4713–4716. [Google Scholar] [CrossRef]
  33. Kirihara, M.; Asai, Y.; Ogawa, S.; Noguchi, T.; Hatano, A.; Hirai, Y. A mild and environmentally benign oxidation of thiols to disulfides. Synthesis 2007, 21, 3286–3289. [Google Scholar] [CrossRef]
  34. Iida, H.; Kozako, R.; Iida, H. Green Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis. Synlett 2021, 32, 1227–1230. [Google Scholar] [CrossRef]
  35. Spiliopoulou, N.; Kokotos, C.G. Photochemical Metal-Free Aerobic Oxidation of Thiols to Disulfides. Green Chem. 2021, 23, 546–551. [Google Scholar] [CrossRef]
  36. Primas, N.; Lano, G.; Brun, D.; Curti, C.; Sallee, M.; Sampol-Manos, E.; Lamy, E.; Bornet, C.; Burtey, S.; Vanelle, P. Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization. Pharmaceuticals 2023, 16, 72. [Google Scholar] [CrossRef] [PubMed]
  37. Galanis, A.S.; Albericio, F.; Grotli, M. Solid-Phase Peptide Synthesis in Water Using Microwave-Assisted Heating. Org. Lett. 2009, 11, 4488–4491. [Google Scholar] [CrossRef] [PubMed]
  38. Asmellash, S.; Stevens, J.L.; Ichimura, T. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicol. Sci. 2005, 11, 576–584. [Google Scholar] [CrossRef]
  39. Yue, H.; Wang, J.; Xie, Z.; Tian, J.; Sang, D.; Liu, S. 1,3-Diisopropylcarbodiimide-Mediated Synthesis of Disulfides from Thiols. ChemistrySelect 2020, 5, 4273–4277. [Google Scholar] [CrossRef]
  40. Xu, H.; Zhang, Y.F.; Lang, X. TEMPO Visible Light Photocatalysis: The Selective Aerobic Oxidation of Thiols to Disulfides. Chin. Chem. Lett. 2020, 31, 1520–1524. [Google Scholar] [CrossRef]
  41. Song, L.; Li, W.; Duan, W.; An, J.; Tang, S.; Li, L.; Yang, G. Natural Gallic Acid Catalyzed Aerobic Oxidative Coupling with the Assistance of MnCO3 for Synthesis of Disulfanes in Water. Green Chem. 2019, 21, 1432–1438. [Google Scholar] [CrossRef]
  42. Bhattacherjee, D.; Sufian, A.; Mahato, S.K.; Begum, S.; Banerjee, K.; De, S.; Srivastava, H.K.; Bhabak, K.P. Trisulfides over Disulfides: Highly Selective Synthetic Strategies, Anti-Proliferative Activities and Sustained H2S Release Profiles. Chem. Commun. 2019, 55, 13534–13537. [Google Scholar] [CrossRef] [PubMed]
  43. Howard, J.L.; Schotten, C.; Alston, S.T.; Browne, D.L. Preparation of Difluoromethylthioethers through Difluoromethylation of Disulfides Using TMS-CF2H. Chem. Commun. 2016, 52, 8448–8451. [Google Scholar] [CrossRef] [PubMed]
  44. Hayashi, M.; Okunaga, K.; Nishida, S.; Kawamura, K.; Eda, K. Oxidative Transformation of Thiols to Disulfides Promoted by Activated Carbon–Air System. Tetrahedron. Lett. 2010, 51, 6734–6736. [Google Scholar] [CrossRef]
  45. Bottecchia, C.; Erdmann, N.; Tijssen, P.M.A.; Milroy, L.G.; Brunsveld, L.; Hessel, V.; Noel, T. Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis. Chemsuschem 2016, 9, 1781–1785. [Google Scholar] [CrossRef] [PubMed]
  46. Calandra, N.A.; Cheng, Y.L.; Kocak, K.A.; Miller, J.S. Total Synthesis of Spiruchostatin A via Chemoselective Macrocyclization using an Accessible Enantiomerically Pure Latent Thioester. Org. Lett. 2009, 11, 1971–1974. [Google Scholar] [CrossRef] [PubMed]
Figure 1. Representative applications of disulfides.
Figure 1. Representative applications of disulfides.
Molecules 28 06789 g001
Figure 2. The synthesis of disulfide occurs via I2-catalyzed aerobic oxidation. Reaction conditions: thiols (0.3 mM), I2 (5 mol%), EtOAc, oxygen balloon (0.3 MPa), 70 °C, 4 h.
Figure 2. The synthesis of disulfide occurs via I2-catalyzed aerobic oxidation. Reaction conditions: thiols (0.3 mM), I2 (5 mol%), EtOAc, oxygen balloon (0.3 MPa), 70 °C, 4 h.
Molecules 28 06789 g002
Figure 3. The application of I2-catalyzed aerobic oxidation for derivatives of cysteine.
Figure 3. The application of I2-catalyzed aerobic oxidation for derivatives of cysteine.
Molecules 28 06789 g003
Figure 4. The application of I2-catalyzed aerobic oxidation for dithiothreitol.
Figure 4. The application of I2-catalyzed aerobic oxidation for dithiothreitol.
Molecules 28 06789 g004
Scheme 1. Experimental strategy for determining the reaction mechanism. (A): Experimental strategy; (B): Catalytic cycle route.
Scheme 1. Experimental strategy for determining the reaction mechanism. (A): Experimental strategy; (B): Catalytic cycle route.
Molecules 28 06789 sch001
Table 1. Reaction condition optimization of the I2-catalyzed aerobic oxidative coupling of thiols.
Table 1. Reaction condition optimization of the I2-catalyzed aerobic oxidative coupling of thiols.
Molecules 28 06789 i001
EntrySolventCatalyst (mol%)Temperature
(°C)
Time
(h)
Yield a
(%)
1EtOAc10704>98
2EtOAc5.0704>98
3EtOAc1.070446
4EtOAc5.070149
5DCM5.070423
6DMF5.070422
7EtOAc5.0r.t.453
8EtOAcno7043
a Determined by 1H NMR.
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Wang, L.; Chen, L.; Qin, Z.; Ni, K.; Li, X.; Yu, Z.; Kuang, Z.; Qin, X.; Duan, H.; An, J. Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations. Molecules 2023, 28, 6789. https://doi.org/10.3390/molecules28196789

AMA Style

Wang L, Chen L, Qin Z, Ni K, Li X, Yu Z, Kuang Z, Qin X, Duan H, An J. Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations. Molecules. 2023; 28(19):6789. https://doi.org/10.3390/molecules28196789

Chicago/Turabian Style

Wang, Lijun, Lingxia Chen, Zixuan Qin, Ke Ni, Xiao Li, Zhiyuan Yu, Zichen Kuang, Xinshu Qin, Hongxia Duan, and Jie An. 2023. "Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations" Molecules 28, no. 19: 6789. https://doi.org/10.3390/molecules28196789

APA Style

Wang, L., Chen, L., Qin, Z., Ni, K., Li, X., Yu, Z., Kuang, Z., Qin, X., Duan, H., & An, J. (2023). Application of Iodine as a Catalyst in Aerobic Oxidations: A Sustainable Approach for Thiol Oxidations. Molecules, 28(19), 6789. https://doi.org/10.3390/molecules28196789

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