Molecules

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Industrial Organic Chemicals. Starting Materials and Intermediates

by Shu-Kun Lin

Molecules 1999, 4(12), 371-372; https://doi.org/10.3390/41200371 - 31 Dec 1999

Cited by 4 | Viewed by 5100

The encyclopedia of Industrial Organic Chemicals brings together around 200 detailed and thoroughly edited articles on organic starting materials and intermediates.[...] Full article

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Open AccessBook Review

Ullmann’s Encyclopedia of Industrial Chemistry. CD-ROM. 6th Edition 1999 Electronic Release

by Shu-Kun Lin

Molecules 1999, 4(12), 368-370; https://doi.org/10.3390/41200368 - 31 Dec 1999

Cited by 2 | Viewed by 7411

Abstract

When I was being trained in dyestuff research, development and production at Ciba-Geigy in 1994, my supervisors as senior dyestuff chemists, brought to my attention the Ullmann’s Encyclopedia of Industrial Chemistry.[...] Full article

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Open AccessBook Review

Molecular Catenanes, Rotaxanes and Knots. A Journey Through the World of Molecular Topology. Edited by J.-P. Sauvage

by Shu-Kun Lin

Molecules 1999, 4(12), 366-367; https://doi.org/10.3390/41200366 - 31 Dec 1999

Cited by 2 | Viewed by 4753

Abstract

The parts of a molecule are connected by chemical bonds such as the covalent bond, the ionic bond, the hydrogen bond, etc.[...] Full article

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Open AccessShort Note

N-{2-[(2-Oxo-2H-chromen-4-yl)amino]ethyl}acetamide

by Stoyan K. Karagiosov, Ivo C. Ivanov and Boyan I. Iliev

Molecules 1999, 4(12), M126; https://doi.org/10.3390/M126 - 17 Dec 1999

Cited by 4 | Viewed by 3140

Abstract

The direct synthesis of 4-(monoalkylamino)coumarins from primary amines [1] was developed on the basis of the reaction of 4-hydroxycoumarin with ammonium acetate in acetic acid as reported by Joshi et al. [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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Open AccessShort Note

6-Methyl-3-nitroso-1-phenethyl-4-(phenethylamino)-2(1H)-pyridinone

by Edmont V. Stoyanov and Ivo C. Ivanov

Molecules 1999, 4(12), M125; https://doi.org/10.3390/M125 - 17 Dec 1999

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Abstract

In the course of our recent studies on the reactivity of some 4-amino-2-pyridones [1-3] we accomplished the nitrosation of the N,N-disubstituted 4-amino-2-pyridone 2.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

83 KiB

Open AccessArticle

Teaching NMR Using Online Textbooks

by Joseph P. Hornak

Molecules 1999, 4(12), 353-365; https://doi.org/10.3390/41200353 - 1 Dec 1999

Cited by 3 | Viewed by 8309

Abstract

Nuclear magnetic resonance (NMR) spectroscopy has almost become an essential analytical tool for the chemist. High-resolution one- and multi-dimensional NMR, timedomain NMR, and NMR microscopy are but a few of the NMR techniques at a chemist's disposal to determine chemical structure and dynamics. [...] Read more.

Nuclear magnetic resonance (NMR) spectroscopy has almost become an essential analytical tool for the chemist. High-resolution one- and multi-dimensional NMR, timedomain NMR, and NMR microscopy are but a few of the NMR techniques at a chemist's disposal to determine chemical structure and dynamics. Consequently, even small chemistry departments are finding it necessary to provide students with NMR training and experience in at least some of these techniques. The hands-on experience is readily provided with access to state-of-the-art commercial spectrometers. Instruction in the principles of NMR is more difficult to achieve as most instructors try to teach NMR using single organic or analytical chemistry book chapters with static figures. This paper describes an online textbook on NMR spectroscopy called The Basics of NMR (http://www.cis.rit.edu/htbooks/nmr/) suitable for use in teaching the principles of NMR spectroscopy. The book utilizes hypertext and animations to present the principles of NMR spectroscopy. The book can be used as a textbook associated with a lecture or as a stand-alone teaching tool. Conference participants are encouraged to review the textbook and evaluate its suitability for us in teaching NMR spectroscopy to undergraduate chemistry majors. Full article

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221 KiB

Open AccessArticle

X-Ray Crystal Structure of 10β-Hydroxy-4β,5β-epoxyestr-1-en-3,17-dione and Antitumor Activity of its Congeners

by Dragana R. Milić, Agneš Kapor, Borislava Markov, Bela Ribar, Marianne Strümpel, Zorica Juranić, Miroslav J. Gašić and Bogdan A. Šolaja

Molecules 1999, 4(12), 338-352; https://doi.org/10.3390/41200338 - 23 Nov 1999

Cited by 9 | Viewed by 8091

Abstract

Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in [...] Read more.

Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in the asymmetric unit each consisting of four fused rings with the C(10) β-oriented hydroxy group and β-oriented O atom bridging C(4) and C(5). The conformation of A ring in both conformers A and B is boat (B_3,6), while rings B and C are chairs (¹C₄) and the five-membered D ring is in an envelope (E₂) conformation. The in vitro antitumor activity of title compound and its 17b-acetoxy analogue against HeLa and Fem-x cells revealed IC₅₀ values of 5.7 and 7.1 mM, and 2.25 and 1.58 mM, respectively. Corresponding quinols were tested on 47 cell lines with 10b-hydroxy-17β-acetoxyestra-1,4-dien-3-one being most active against leukemia SR cells (GI₅₀ = 0.17 mM). Full article

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Molecules, Volume 4, Issue 12 (December 1999) – 7 articles , Pages 338-372, Articles M125-M126

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