Molecules

509 KiB

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The Chemistry of α-Haloketones and Their Utility in Heterocyclic Synthesis

by Ayman W. Erian, Sherif M. Sherif and Hatem M. Gaber

Molecules 2003, 8(11), 793-865; https://doi.org/10.3390/81100793 - 15 Nov 2003

Cited by 194 | Viewed by 28736

The molecular structures and spectral properties of α-haloketones as well as their syntheses are analyzed and reviewed. Their reactivity towards oxygen, nitrogen, and sulfur nucleophiles, carboxylic acids, carbon nucleophiles, alkenes, and alkynes are discussed. Full article

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53 KiB

Open AccessArticle

Synthesis and Characterization of Chiral Nitrobenzaldehyde - Schiff Base Ligands

by Wen Tao Gao and Zhuo Zheng

Molecules 2003, 8(11), 788-792; https://doi.org/10.3390/81100788 - 15 Nov 2003

Cited by 14 | Viewed by 9735

Abstract

Three chiral nitrobenzaldehyde/Schiff base ligands (2a-c) were prepared by the reaction of ortho, meta, and para-NO₂ substituted benzaldehydes (1a-c) with (1R,2R)-(-)-1,2-diaminocyclohexane. The structures of ligands 2a-c were characterized by IR, ¹H-NMR, ¹³C-NMR and elemental analysis. Full article

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57 KiB

Open AccessArticle

Synthesis and X-Ray Structure of [N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane](3,5-dimethylpyrazole) copper(II) dinitrate

by Mohamed El Kodadi, Fouad Malek, Rachid Touzani, Abdelkrim Ramdani, Sghir El Kadiri and Driss Eddike

Molecules 2003, 8(11), 780-787; https://doi.org/10.3390/81100780 - 15 Nov 2003

Cited by 24 | Viewed by 11541

Abstract

The tridentate ligand N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (L) has been prepared in one step by condensation of two equivalents of 1-hydroxymethyl-3,5-dimethylpyrazole with one equivalent of 2-aminoethanol. This reaction is carried out under microwave irradiation (60 W) in the absence of solvent for 20 min [1]. Using this ligand L a new Cu(II) dinitrate complex has been prepared. The singlecrystal X-ray structure of the title compound, [N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane] (3,5-dimethylpyrazole)copper(II) dinitrate, revels that the copper (II) ion is coordinated to two pyrazole nitrogens, one tertiary amine nitrogen of the ligand L and 3,5-dimethylpyrazole, and in the apical position by an alcohol O atom. Full article

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127 KiB

Open AccessArticle

Structure of Sulfated Monosaccharides Studied by Quantum Chemical Methods

by Eva Scholtzová, Pavel Mach and Miloš Hricovíni

Molecules 2003, 8(11), 770-779; https://doi.org/10.3390/81100770 - 15 Nov 2003

Cited by 5 | Viewed by 9475

Abstract

Ab initio and DFT analysis have been used to study of geometry of sulfated monosaccharides GlcN,6-SO₃^- and IdoA 2-SO₃^- in solvent. The computed low conformational barrier between the interconverting conformers of the IdoA 2-SO₃^- residue is in agreement with experimental data. Full article

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301 KiB

Open AccessArticle

Synthesis and Biological Evaluation of Quinazoline-4-thiones

by Lenka Kubicová, Martin Šustr, Katarína Kráľová, Vladimír Chobot, Jitka Vytlačilová, Luděk Jahodář, Pia Vuorela, Miloš Macháček and Jarmila Kaustová

Molecules 2003, 8(11), 756-769; https://doi.org/10.3390/81100756 - 15 Nov 2003

Cited by 30 | Viewed by 10611

Abstract

Several 2,2-dimethyl-3-phenyl-1,2-dihydroquinazoline-4(3H)-thiones and 2-methyl-3-phenylquinazoline-4(3H)-thiones were synthesized and tested for their antimycobacterial, photosynthesis-inhibiting, and antialgal activity. Antimycobacterially active compounds were found among the 6-chloro substituted compounds. 6-Chloro-3-(4-isopropylphenyl)-2-methylquinazoline-4(3H)-thione exhibited higher activity than the isoniazid standard against Mycobacterium avium and M. kansasii. Most of the compounds possessed photosynthesis-inhibiting activity. 6-Chloro-2,2-dimethyl-3-phenyl-1,2-dihydroquinazoline-4(3H)-thione and its 3´-chloro- and 3´,4´-dichloro analogs were most effective in the inhibition of oxygen evolution rate in spinach chloroplasts. Of compounds selected for toxicological screening, 6-chloro-3-(4-isopropylphenyl)-2-methyl-quinazoline-4(3H)-thione was the only one active in the brine shrimp bioassay. Full article

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Molecules, Volume 8, Issue 11 (November 2003) – 5 articles , Pages 756-865

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