Assessment of the Efficacy and Clinical Utility of Different Circulating Tumor Cell (CTC) Detection Assays in Patients with Chemotherapy-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
, Ippokratis Messaritakis 1, Oraianthi Fiste 2, John Souglakos 1,3, Eleni Politaki 1, Athanasios Kotsakis 4, Vassilis Georgoulias 5, Dimitrios Mavroudis 1,3 and Sofia Agelaki 1,3,*Round 1
Reviewer 1 Report
In the manuscript » Assessment of the efficacy and clinical utility of different circulating tumor cell (CTC) detection assays in patients with chemotherapy-naïve advanced or metastatic non-small cell lung cancer (NSCLC) « the authors compare detection of CTC using CellSearch device with CTC assessment based on mRNA detection. Their findings are very interesting since both methods showed negative prognostic value in positive patients even if the positive concordance of both methods was low. The authors concluded, that both methods of assessment could be used in combination.
The authors nicely describe the background of their study in the introduction section of the manuscript. The presentation of the results is clear and provides sufficient data on the baseline assessment and after the treatment with systemic chemotherapy. The discussion section is clear and conclusions are straightforward as well as practically useful. The number of the patient’s population is appropriate and the description of both methods used is thorough. The reference section is relevant and sources seem reliable.
Author Response
We would like to thank the Reviewer for taking the time to review the current manuscript.
Reviewer 2 Report
The manuscript entitled "Assessment of the efficacy and clinical utility of different circulating tumor cell (CTC) detection assays in patients with chemotherapy-naïve advanced or metastatic non-small cell lung cancer (NSCLC)" highlighted that CTC detection and monitoring using the CellSearch and CEACAM5mRNA assays, provides valuable and complementary clinical information for chemo-naïve advanced and metastatic NSCLC.
- The Authors should provide the extensive forms for all acronyms through the text when they first appear.
- In tables the Authors should provide the abbreviations.
Author Response
We would like to thank the Reviewer for the comments. In the revised manuscript, we have included the extensive forms for all acronyms through the text when they first appear, as well the abbreviations within the legends of the tables.
