The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage
, Antonio Salvati 2, Mariarosaria Distaso 1, Daniela Campani 3, Francesco Raggi 1, Edoardo Biancalana 4, Domenico Tricò 4, Maurizia Rossana Brunetto 4,* and Anna Solini 1,*
Round 1
Reviewer 1 Report
Although the authors revised the manuscript to strengthen their conclusion, some noticeable weaknesses still existed.
1) In Fig. 4, confocal images with a thin optical thickness (7 μm) do not necessarily imply that both are in the same focal plane. Axial resolution should be considered. In addition, there were more than 4 cells showing the yellow fluorescence (potentially co-localization) while only 4 arrows were presented in the figure.
2) In Fig. 5, strong red fluorescence was also observed in the non-centrilobular area. Just manipulating the brightness and/or contrast would not strengthen the conclusion.
3) Although the authors put some efforts not to overstate the conclusion, the abstract and result were almost identical to the original manuscript.
Author Response
Please see the attachment
Author Response File: 
Author Response.docx
Reviewer 2 Report
The authors resubmitted the manuscript, in which they revised the previous one with addressing the reviewer's comments appropriately.
Author Response
Please see the attachment
Author Response File: Author Response.docx
