Next Article in Journal
Intracranial Virotherapy for a Canine Hemangioma
Next Article in Special Issue
Moderator Effect of Hypoalbuminemia in Volume Resuscitation and Plasma Expansion with Intravenous Albumin Solution
Previous Article in Journal
3β-Corner Stability by Comparative Molecular Dynamics Simulations
Previous Article in Special Issue
Interaction of miR-155 with Human Serum Albumin: An Atomic Force Spectroscopy, Fluorescence, FRET, and Computational Modelling Evidence
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 19
10.3390/ijms231911675
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Communication
Peer-Review Record

Human Serum Albumin Misfolding in Aging and Disease

Int. J. Mol. Sci. 2022, 23(19), 11675; https://doi.org/10.3390/ijms231911675
by Francis H. C. Tsao * and Keith C. Meyer
Reviewer 1: Anonymous
Reviewer 2:
Sachchida Nand Rai
Int. J. Mol. Sci. 2022, 23(19), 11675; https://doi.org/10.3390/ijms231911675
Submission received: 29 August 2022 / Revised: 15 September 2022 / Accepted: 30 September 2022 / Published: 2 October 2022
(This article belongs to the Special Issue Serum Albumin in Health and Disease: From Comparative Biochemistry to Translational Medicine)

Round 1

Reviewer 1 Report

I read the manuscript "Human Serum Albumin Misfolding in Aging and Disease". Overall, I don't think this paper meets the criteria for publication in the Journal IJMS. I fail to see the impact of this manuscript. 

This communication looks like a review of the authors' recent published papers (the bibliography only counts 6 citations, 5 of which are from the authors), no additional background was described to highlight the novelty and the impact of the publication. Communications may not require the same standards as full articles, but this manuscript needs extensive editing, starting from the background/literature references. 

Looking at the results, the graph reported is from a single experiment. The statistical analysis is described, but not plotted in the graph. Why did authors choose to precisely analyse 74 and 24-yo individuals? It seems a highly restrictive selection, I would suggest to enlarge the sample diversity, as well as the sample size to have a more realistic variation.  

Apart from this, changes are needed in the English, as several paragraphs have long sentences that result in poor clarity.  

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

I have some comments on the manuscript entitled “Human Serum Albumin Misfolding in Aging and Disease”.

1.       Write limitations of your study at the end of the abstract section.

2.       Significant value is missing in the histograms.

3.       Elaborate the communication section a little bit.

4.       Complete editorial checking will be needed to correct the grammatical and punctuation mistakes.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

I see and appreciate the extensive work done by authors to improve their manuscript, but I'm not changing my mind. More and more relevant results are required to publish a communication in ijms, so once again i support rejection of this ms. 

Back to TopTop