A Comparison of PET Tracers in Recurrent High-Grade Gliomas: A Systematic Review

Round 1

Reviewer 1 Report

This is a systematic review of the use of PET imaging in recurrent high grade glioma including several radio tracers that have been studied in clinical practice.

The subject is well presented. The article is well written and easy to follow.

It provides a clear overview of the literature regarding Pet imaging in recurrent glioma including physiological basis for all radio tracers and data on efficacy and limitation on each.

It also attempts to summarize and determine the best radiotacer available.

The conclusion is appropriate .

Author Response

We thank the reviewer for the comments and feedback.

Reviewer 2 Report

Due to the limitations of enhanced magnetic resonance imaging in the application of recurrent high-grade gliomas, the authors highlight several PET radiotracers that can address these limitations and provide a comparison between them to assess the efficacy of these tracers. I recommend the article for publication after revisions.

In order to enrich the article, here I make two suggestions:

1: The author lists several tracers modified from amino acid, but does not include the glutamine tracer 18F-FGln. It is suggested to briefly describe the application of 18F-FGln in brain glioma and its advantages and disadvantages.

 2. In recent years, FAP imaging agent is also very popular, and there are some imaging studies on brain metastases of glioma.  It is suggested to make a simple description of the brain diagnosis research of FAP imaging agent in the column of other imaging agents listed.

Author Response

Please see the attachment. We thank the reviewer for the feedback. 

Author Response File: Author Response.docx