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Volume 24
Issue 3
10.3390/ijms24032807
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Article
Peer-Review Record

Characterization of Metal-Specific T-Cells in Inflamed Oral Mucosa in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

Int. J. Mol. Sci. 2023, 24(3), 2807; https://doi.org/10.3390/ijms24032807
by Takamasa Yoshizawa 1,2,†, Kenichi Kumagai 2,3,†, Ryota Matsubara 2,4, Keisuke Nasu 1,2, Kazutaka Kitaura 2,5, Motoaki Suzuki 2,6, Yoshiki Hamada 1,* and Ryuji Suzuki 2,5
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(3), 2807; https://doi.org/10.3390/ijms24032807
Submission received: 27 December 2022 / Revised: 23 January 2023 / Accepted: 29 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue Oral Medicine and Immunity)

Round 1

Reviewer 1 Report

Please open the attached file.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

In this paper the authors present a novel murine model of chromium-induced allergic contact dermatitis. The manuscript is well written and structured. I have several minor suggestions.

In the Introduction Section, the authors should include more data on intraoral metal allergy, focusing on the one induced by chromium. An interesting article is doi: 10.3390/dj8030083

In the Discussion Section, the authors should discuss more about the toxic effects of chromium. It would be useful to include data from this article, doi: 10.5772/intechopen.90347

The authors mention the terms "a delayed-type hypersensitivity" and "type IV allergy". They should specify that type IV hypersensitivity reactions are also known as delayed-type hypersensitivity reactions.

Lines 267-270 "The stimulated inflammation at the inflammation site gradually decreased in the ICM group 7 days post challenge". Please rephrase it.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors satisfactorily addressed all comments and suggestions. Thank you.

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