The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

Fan, Xiaoyu; Ye, Jinhong; Zhong, Wanling; Shen, Huijuan; Li, Huahua; Liu, Zhuyuan; Bai, Jie; Du, Shouying

doi:10.3390/ijms252312561

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Open AccessReview

The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

by

Xiaoyu Fan

,

Jinhong Ye

,

Wanling Zhong

,

Huijuan Shen

,

Huahua Li

,

Zhuyuan Liu

,

Jie Bai

^* and

Shouying Du

^*

College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2024, 25(23), 12561; https://doi.org/10.3390/ijms252312561

Submission received: 18 October 2024 / Revised: 15 November 2024 / Accepted: 21 November 2024 / Published: 22 November 2024

(This article belongs to the Section Molecular Biology)

Download

Browse Figure

Versions Notes

Abstract

The skin is the first line of defense to protect the host from external environmental damage. When the skin is damaged, the wound provides convenience for the invasion of external substances. The prolonged nonhealing of wounds can also lead to numerous subsequent complications, seriously affecting the quality of life of patients. To solve this problem, proteins and peptide components that promote wound healing have been discovered in animals, which can act on key pathways involved in wound healing, such as the PI3K/AKT, TGF-β, NF-κ B, and JAK/STAT pathways. So far, some formulations for topical drug delivery have been developed, including hydrogels, microneedles, and electrospinning nanofibers. In addition, some high-performance dressings have been utilized, which also have great potential in wound healing. Here, research progress on the promotion of wound healing by animal-derived proteins and peptide components is summarized, and future research directions are discussed.

Keywords: wound healing; protein; peptide; component; mechanism; formulation; dressing

Graphical Abstract

Share and Cite

MDPI and ACS Style

Fan, X.; Ye, J.; Zhong, W.; Shen, H.; Li, H.; Liu, Z.; Bai, J.; Du, S. The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review. Int. J. Mol. Sci. 2024, 25, 12561. https://doi.org/10.3390/ijms252312561

AMA Style

Fan X, Ye J, Zhong W, Shen H, Li H, Liu Z, Bai J, Du S. The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review. International Journal of Molecular Sciences. 2024; 25(23):12561. https://doi.org/10.3390/ijms252312561

Chicago/Turabian Style

Fan, Xiaoyu, Jinhong Ye, Wanling Zhong, Huijuan Shen, Huahua Li, Zhuyuan Liu, Jie Bai, and Shouying Du. 2024. "The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review" International Journal of Molecular Sciences 25, no. 23: 12561. https://doi.org/10.3390/ijms252312561

APA Style

Fan, X., Ye, J., Zhong, W., Shen, H., Li, H., Liu, Z., Bai, J., & Du, S. (2024). The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review. International Journal of Molecular Sciences, 25(23), 12561. https://doi.org/10.3390/ijms252312561

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.

Article Menu

The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

Abstract

Share and Cite

Article Metrics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI