Next Article in Journal
2-{N-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ1/2 Receptors
Previous Article in Journal
Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer’s Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
Previous Article in Special Issue
Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 3
10.3390/ijms26031267
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma

by
Gabriela Cristina Avertano Rocha da Silveira
1,
Rebeca Vieira Costa
1,
Flavia Letícia Magalhães Lemos
1,
Antonia Taiane Lopes de Moraes
2,
Maria Sueli da Silva Kataoka
3,
Vanessa Morais Freitas
4,
Silvio Augusto Fernandes de Menezes
5,
Ana Carolina Uchoa Vasconcelos
6,
Adriana Etges
6,
Fabricio Passador Santos
7,
Vera Cavalcanti de Araújo
7,
Sérgio de Melo Alves Júnior
1,†,
Ruy Gastaldoni Jaeger
4,† and
João de Jesus Viana Pinheiro
1,*
1
Laboratory of Pathological Anatomy and Immunohistochemistry, School of Dentistry, Federal University of Pará, Belém 66075-110, PA, Brazil
2
Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil
3
Cell Culture Laboratory, School of Dentistry, Federal University of Pará, Belém 66075-110, PA, Brazil
4
Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil
5
Department of Periodontics, University Center of Pará, Belém 66060-232, PA, Brazil
6
Center for the Diagnosis of Diseases of the Mouth, School of Dentistry, Federal University of Pelotas, Pelotas 96010-610, RS, Brazil
7
Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas 13045-755, SP, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the manuscript.
Int. J. Mol. Sci. 2025, 26(3), 1267; https://doi.org/10.3390/ijms26031267
Submission received: 30 December 2024 / Revised: 28 January 2025 / Accepted: 29 January 2025 / Published: 31 January 2025
(This article belongs to the Special Issue The Biology and Therapeutic Potential of Metalloproteases)
Versions Notes

Abstract

Background: the aim of this study was to verify whether the expression of proteins related to the formation of invadopodia, MT1-MMP, cortactin, Tks-4 and Tks-5 is associated with the degree of tumor invasiveness of different types of unicystic ameloblastomas. Methods: an immunohistochemical study was performed on 29 unicystic ameloblastoma (UA) samples, 9 conventional ameloblastoma (CAM) samples and 9 dental follicle (DF) samples. The potential for tumor invasiveness was assessed based on the immunoexpression of the following invadopodia-forming proteins: MT1-MMP, cortactin, Tks-4 and Tks5. Results: mural unicystic ameloblastoma (MUA) showed higher MT1-MMP, cortactin, Tks-4, and Tks-5 immunoexpression than luminal and intra-luminal types. Conventional ameloblastoma exhibited lower MT1-MMP, cortactin, and Tks-5 expression compared to MUA. MUA’s cystic capsule neoplastic cells had significantly higher MT1-MMP, cortactin, Tks-4, and Tks-5 expression than lumen cells. Dental follicles showed minimal expression. Conclusions: neoplastic cells in the cystic capsule of mural unicystic ameloblastomas showed higher invadopodia-related protein expression than lumen and luminal/intraluminal cells, suggesting that proximity to the bone region influences the aggressive behavior of mural unicystic ameloblastomas more compared to other subtypes.
Keywords: ameloblastoma; immunohistochemistry; invadopodium; odontogenic tumor; pathology ameloblastoma; immunohistochemistry; invadopodium; odontogenic tumor; pathology

Share and Cite

MDPI and ACS Style

Silveira, G.C.A.R.d.; Costa, R.V.; Lemos, F.L.M.; de Moraes, A.T.L.; Kataoka, M.S.d.S.; Freitas, V.M.; de Menezes, S.A.F.; Vasconcelos, A.C.U.; Etges, A.; Santos, F.P.; et al. Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma. Int. J. Mol. Sci. 2025, 26, 1267. https://doi.org/10.3390/ijms26031267

AMA Style

Silveira GCARd, Costa RV, Lemos FLM, de Moraes ATL, Kataoka MSdS, Freitas VM, de Menezes SAF, Vasconcelos ACU, Etges A, Santos FP, et al. Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma. International Journal of Molecular Sciences. 2025; 26(3):1267. https://doi.org/10.3390/ijms26031267

Chicago/Turabian Style

Silveira, Gabriela Cristina Avertano Rocha da, Rebeca Vieira Costa, Flavia Letícia Magalhães Lemos, Antonia Taiane Lopes de Moraes, Maria Sueli da Silva Kataoka, Vanessa Morais Freitas, Silvio Augusto Fernandes de Menezes, Ana Carolina Uchoa Vasconcelos, Adriana Etges, Fabricio Passador Santos, and et al. 2025. "Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma" International Journal of Molecular Sciences 26, no. 3: 1267. https://doi.org/10.3390/ijms26031267

APA Style

Silveira, G. C. A. R. d., Costa, R. V., Lemos, F. L. M., de Moraes, A. T. L., Kataoka, M. S. d. S., Freitas, V. M., de Menezes, S. A. F., Vasconcelos, A. C. U., Etges, A., Santos, F. P., de Araújo, V. C., Alves Júnior, S. d. M., Jaeger, R. G., & Pinheiro, J. d. J. V. (2025). Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma. International Journal of Molecular Sciences, 26(3), 1267. https://doi.org/10.3390/ijms26031267

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop