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Volume 13
Issue 2
10.21775/cimb.013.051
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Filamentous Bacteriophage: Biology, Phage Display and Nanotechnology Applications

by
Jasna Rakonjac
1,*,
Nicholas J. Bennett
1,†,
Julian Spagnuolo
1,
Dragana Gagic
1,‡ and
Marjorie Russel
2
1
Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand
2
The Rockefeller University, New York, NY, USA
*
Author to whom correspondence should be addressed.
†
Current address: Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
‡
Current address: AgResearch Grasslands, Palmerston North, New Zealand.
Curr. Issues Mol. Biol. 2011, 13(2), 51-76; https://doi.org/10.21775/cimb.013.051
Submission received: 5 October 2010 / Revised: 7 December 2010 / Accepted: 7 February 2011 / Published: 18 April 2011

Abstract

Filamentous bacteriophage, long and thin filaments that are secreted from the host cells without killing them, have been an antithesis to the standard view of head-and-tail bacterial killing machines. Episomally replicating filamentous phage Ff of Escherichia coli provide the majority of information about the principles and mechanisms of filamentous phage infection, episomal replication and assembly. Chromosomally- integrated "temperate" filamentous phage have complex replication and integration, which are currently under active investigation. The latter are directly or indirectly implicated in diseases caused by bacterial pathogens Vibrio cholerae, Pseudomonas aeruginosa and Neisseria meningitidis. In the first half of the review, both the Ff and temperate phage are described and compared. A large section of the review is devoted to an overview of phage display technology and its applications in nanotechnology.
Keywords: phage display technology; nanotechnology; filamentous bacteriophage; filamentous phage Ff; filamentous phage infection; episomal replication; temperate filamentous phage; Ff phage phage display technology; nanotechnology; filamentous bacteriophage; filamentous phage Ff; filamentous phage infection; episomal replication; temperate filamentous phage; Ff phage

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MDPI and ACS Style

Rakonjac, J.; Bennett, N.J.; Spagnuolo, J.; Gagic, D.; Russel, M. Filamentous Bacteriophage: Biology, Phage Display and Nanotechnology Applications. Curr. Issues Mol. Biol. 2011, 13, 51-76. https://doi.org/10.21775/cimb.013.051

AMA Style

Rakonjac J, Bennett NJ, Spagnuolo J, Gagic D, Russel M. Filamentous Bacteriophage: Biology, Phage Display and Nanotechnology Applications. Current Issues in Molecular Biology. 2011; 13(2):51-76. https://doi.org/10.21775/cimb.013.051

Chicago/Turabian Style

Rakonjac, Jasna, Nicholas J. Bennett, Julian Spagnuolo, Dragana Gagic, and Marjorie Russel. 2011. "Filamentous Bacteriophage: Biology, Phage Display and Nanotechnology Applications" Current Issues in Molecular Biology 13, no. 2: 51-76. https://doi.org/10.21775/cimb.013.051

APA Style

Rakonjac, J., Bennett, N. J., Spagnuolo, J., Gagic, D., & Russel, M. (2011). Filamentous Bacteriophage: Biology, Phage Display and Nanotechnology Applications. Current Issues in Molecular Biology, 13(2), 51-76. https://doi.org/10.21775/cimb.013.051

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