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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells

by
J. T. Trevors
1,*,
J. D. van Elsas
2,* and
A.K. Bej
3,*
1
Laboratory of Microbiology, School of Environmental Sciences, University of Guelph, 50 Stone Rd. East, Guelph, ON N1G 2W1 Canada
2
Biological Center, University of Groningen, Kerklaan 30, The Netherlands
3
College of Arts and Science, Dept. Biology, 464 Campbell Hall, University of Alabama at Birmingham, AL 35294, USA
*
Authors to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2013, 15(1), 1-6; https://doi.org/10.21775/cimb.015.001
Submission received: 3 October 2011 / Revised: 6 December 2011 / Accepted: 7 February 2012 / Published: 18 April 2012

Abstract

In this perspective, we discuss the cytoplasm in actively growing bacterial cells contrasted with viable but nonculturable (VBNC) cells. Actively growing bacterial cells contain a more molecularly crowded and organized cytoplasm, and are capable of completing their cell cycle resulting in cell division. In contrast, nutrient starving bacteria in the physiological VBNC state are struggling to survive, as essential nutrients are not available or limiting. The cytoplasm is not as molecularly crowded as gene expression is minimal (e.g., ribosome, transcript, tRNA and protein numbers are decreased), energy pools are depleted, cells may exhibit leakage, and DNA is not being replicated for cell division.
Keywords: cytoplasm; actively growing bacterial cells; viable but nonculturable; VBNC cells; bacterial cells; cell division; VBNC cytoplasm; actively growing bacterial cells; viable but nonculturable; VBNC cells; bacterial cells; cell division; VBNC

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MDPI and ACS Style

Trevors, J.T.; van Elsas, J.D.; Bej, A.K. The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells. Curr. Issues Mol. Biol. 2013, 15, 1-6. https://doi.org/10.21775/cimb.015.001

AMA Style

Trevors JT, van Elsas JD, Bej AK. The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells. Current Issues in Molecular Biology. 2013; 15(1):1-6. https://doi.org/10.21775/cimb.015.001

Chicago/Turabian Style

Trevors, J. T., J. D. van Elsas, and A.K. Bej. 2013. "The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells" Current Issues in Molecular Biology 15, no. 1: 1-6. https://doi.org/10.21775/cimb.015.001

APA Style

Trevors, J. T., van Elsas, J. D., & Bej, A. K. (2013). The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells. Current Issues in Molecular Biology, 15(1), 1-6. https://doi.org/10.21775/cimb.015.001

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