Next Article in Journal
The influence of fluid balance on intra-abdominal pressure after major abdominal surgery
Previous Article in Journal
The links between learning load and well-being of high school seniors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 44
Issue 6
10.3390/medicina44060054
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Association between cadmium and breast cancer

by
Loreta Strumylaitė
1,*,
Algirdas Boguševičius
2,
Stanislovas Ryselis
1,
Darius Pranys
3,
Lina Poškienė
3,
Rima Kregždytė
1,
Olegas Abdrachmanovas
1 and
Rūta Asadauskaitė
1
1
Institute for Biomedical Research
2
Department of Surgery
3
Department of Pathological Anatomy, Kaunas University of Medicine, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2008, 44(6), 415; https://doi.org/10.3390/medicina44060054
Submission received: 19 February 2008 / Accepted: 10 May 2008 / Published: 15 May 2008
Versions Notes

Abstract

Cadmium is a known human lung carcinogen, although some studies indicate a link between cadmium exposure and human breast cancer. The objective of this study was to assess cadmium concentration in breast tissue samples of patients with breast cancer and benign breast tumor.
Material and methods. The concentration of cadmium was determined in breast tissue samples of 21 breast cancer and 19 benign tumor patients. Two samples of breast tissue from each patient, i.e. tumor and normal tissue close to tumor, were taken for the analysis. Cadmium was determined by atomic absorption spectrometry (Perkin-Elmer, Zeeman 3030).
Results. In patients with breast cancer, the mean cadmium concentration was 33.1 ng/g (95% CI, 21.9– 44.4) in malignant breast tissue and 10.4 ng/g (95% CI, 5.6–15.2) in normal breast tissue (P=0.002). In patients with benign tumor, the corresponding values were 17.5 ng/g (95% CI, 8.4–26.5) and 11.8 ng/g (95% CI, 5.1– 18.5) (P=0.3144). There was a statistically significant difference in cadmium concentration between malignant and benign breast tissues (P=0.009).
Conclusion. The data obtained show that cadmium concentration is significantly higher in malignant breast tissue as compared with normal breast tissue of the same women or benign breast tissue. Further studies are necessary to determine the association between cadmium concentration in malignant breast tissue and estrogen receptor level, and smoking.
Keywords: cadmium; breast cancer; hormone receptors cadmium; breast cancer; hormone receptors

Share and Cite

MDPI and ACS Style

Strumylaitė, L.; Boguševičius, A.; Ryselis, S.; Pranys, D.; Poškienė, L.; Kregždytė, R.; Abdrachmanovas, O.; Asadauskaitė, R. Association between cadmium and breast cancer. Medicina 2008, 44, 415. https://doi.org/10.3390/medicina44060054

AMA Style

Strumylaitė L, Boguševičius A, Ryselis S, Pranys D, Poškienė L, Kregždytė R, Abdrachmanovas O, Asadauskaitė R. Association between cadmium and breast cancer. Medicina. 2008; 44(6):415. https://doi.org/10.3390/medicina44060054

Chicago/Turabian Style

Strumylaitė, Loreta, Algirdas Boguševičius, Stanislovas Ryselis, Darius Pranys, Lina Poškienė, Rima Kregždytė, Olegas Abdrachmanovas, and Rūta Asadauskaitė. 2008. "Association between cadmium and breast cancer" Medicina 44, no. 6: 415. https://doi.org/10.3390/medicina44060054

APA Style

Strumylaitė, L., Boguševičius, A., Ryselis, S., Pranys, D., Poškienė, L., Kregždytė, R., Abdrachmanovas, O., & Asadauskaitė, R. (2008). Association between cadmium and breast cancer. Medicina, 44(6), 415. https://doi.org/10.3390/medicina44060054

Article Metrics

Back to TopTop