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Article

Tear Nitric Oxide Levels in Behçet’s Disease

by
Yalçın İşcan
1,
Ulviye Yiğit
2,
Betül Tuğcu Çakmak
2,*,
Mehmet Erdoğan
3,
Derya Ars Erdoğan
4,
Veysi Öner
1,*,
Mehmet Taş
1 and
Yılmaz Özyazgan
3
1
Department of Ophthalmology, Batman State Hospital
2
Department of Ophthalmology, Bakırköy Training and Research Hospital
3
Department of Ophthalmology, Cerrahpaşa Medical School, İstanbul University
4
Department of Medical Biology, Haseki Training and Research Hospital, Turkey
*
Authors to whom correspondence should be addressed.
Medicina 2012, 48(11), 81; https://doi.org/10.3390/medicina48110081
Submission received: 18 May 2012 / Accepted: 30 November 2012 / Published: 5 December 2012
Versions Notes

Abstract

The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet’s disease and to compare it with that in healthy subjects. Material and Methods. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm.
Results. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups.
Conclusion. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet’s disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.
Keywords: Behçet’s disease; nitric oxide; uveitis Behçet’s disease; nitric oxide; uveitis

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MDPI and ACS Style

İşcan, Y.; Yiğit, U.; Tuğcu Çakmak, B.; Erdoğan, M.; Erdoğan, D.A.; Öner, V.; Taş, M.; Özyazgan, Y. Tear Nitric Oxide Levels in Behçet’s Disease. Medicina 2012, 48, 81. https://doi.org/10.3390/medicina48110081

AMA Style

İşcan Y, Yiğit U, Tuğcu Çakmak B, Erdoğan M, Erdoğan DA, Öner V, Taş M, Özyazgan Y. Tear Nitric Oxide Levels in Behçet’s Disease. Medicina. 2012; 48(11):81. https://doi.org/10.3390/medicina48110081

Chicago/Turabian Style

İşcan, Yalçın, Ulviye Yiğit, Betül Tuğcu Çakmak, Mehmet Erdoğan, Derya Ars Erdoğan, Veysi Öner, Mehmet Taş, and Yılmaz Özyazgan. 2012. "Tear Nitric Oxide Levels in Behçet’s Disease" Medicina 48, no. 11: 81. https://doi.org/10.3390/medicina48110081

APA Style

İşcan, Y., Yiğit, U., Tuğcu Çakmak, B., Erdoğan, M., Erdoğan, D. A., Öner, V., Taş, M., & Özyazgan, Y. (2012). Tear Nitric Oxide Levels in Behçet’s Disease. Medicina, 48(11), 81. https://doi.org/10.3390/medicina48110081

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