A Scoping Review and Conceptual Model of Social Participation and Mental Health among Refugees and Asylum Seekers
Abstract
:1. Introduction
1.1. Mental Health of RAS
1.2. Gaps in Knowledge and Rationale for This Study
2. Materials and Methods
2.1. Search Strategies
2.2. Data Extraction and Quality Assessment
- (a)
- Concepts and methods addressed regarding social participation among RAS.
- (b)
- Associations between social participation and mental health among RAS.
3. Results
3.1. Description of the Studies
3.2. Social Participation among RAS—Definitions and Conceptual Model
- Regulations and frameworks, conditions and initiatives
- Established societal organizations
- Community organized groups
3.3. Dimension 1: Regulatory Frameworks, Conditions and Initiatives
3.3.1. Domain 1.1. Legal Status, Conditions and Incentives
3.3.2. Domain 1.2. Reception Systems and Targeted Actions
3.3.3. Domain 1.3. Conditions for Political Engagement
3.4. Dimension 2: Established Societal Organizations and Social Structures
3.4.1. Domain 2.1 Labor Market
3.4.2. Domain 2.2 Financial Transactions
3.4.3. Domain 2.3 Education
3.4.4. Domain 2.4 Healthcare
3.5. Dimension 3: Community Organized Groups
3.5.1. Domain 3.1 Ethnic Communities
3.5.2. Domain 3.2 Religious Congregations
3.5.3. Domain 3.3 Sports and Leisure Groups
3.5.4. Domain 3.4 Political Associations
3.5.5. Mental Health Classifications
4. Discussion
Limitations and Strengths
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
Author, Year | Clear Aim | Study Population | Participation Rate | Inclusion and Exclusion | Power Calculation | Exposure | Tieframe | Exposure Level | Exposure Measure | Repeated Assessment | Outcome Variable | Blinding | Dropout | Confounders | Overall Assessment |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Khawaja, 2006 [19] | Yes | Yes | Yes | Yes | No | No | No | No | Yes | No | Yes | CD | NR | Yes | Excellent |
Stewart, 2015 [39] | Yes | Yes | CD | Yes | No | Yes | No | CD | Yes | No | Yes | CD | No | Yes | Good |
Fozdar, 2011 [48] | Yes | Yes | CD | CD | No | No | No | CD | CD | No | CD | CD | NA | Yes | Weak |
Montgomery, 1987 [49] | Yes | Yes | Yes | Yes | Yes | No | No | Yes | Yes | No | Yes | NR | NA | Yes | Excellent |
Bach, 1986 [50] | Yes | Yes | No | Yes | Yes | Yes | CD | NA | Yes | No | Yes | CD | NA | Yes | Good |
Caspi, 1998 [51] | Yes | Yes | Yes | Yes | Yes | No | NA | No | Yes | No | Yes | CD | NA | Yes | Good |
Thanh Van, 1987 [55] | Yes | CD | CD | CD | Yes | No | No | Yes | Yes | No | Yes | CD | NR | Yes | Good |
Gerber, 2017 [57] | Yes | Yes | NR | No | Yes | No | No | No | No | No | No | CD | NA | Yes | Weak |
Haddad, 2002 [66] | Yes | Yes | Yes | Yes | Yes | No | No | Yes | Yes | No | Yes | CD | NA | Yes | Excellent |
Aylesworth, 1983 [67] | Yes | Yes | Yes | Yes | Yes | Yes | No | NA | CD | No | CD | NR | NA | Yes | Good |
Hitch, 1980 [76] | Yes | Yes | Yes | Yes | CD | Yes | Yes | No | No | No | Yes | CD | No | Yes | Excellent |
Makhoul, 2009 [84] | Yes | Yes | Yes | Yes | No | No | No | CD | Yes | No | Yes | CD | NA | CD | Weak |
Jeong, 2016 [87] | Yes | Yes | NR | Yes | No | No | CD | Yes | Yes | No | Yes | CD | NR | Yes | Excellent |
Appendix B
Author, Year | Appropriate Sample | Data Collection | Analysis | Transferability | Ethics | Clarity | Assessment |
---|---|---|---|---|---|---|---|
Brown, 2011 [32] | 3 | 3 | 3 | 3 | 2 | 3 | Excellent |
Da Lomba, 2010 [33] | 1 | 1 | 1 | 3 | 1 | 2 | Satisfactory |
Korac, 2003 [34] | 3 | 1 | 1 | 2 | 1 | 2 | Weak |
Stewart, 2014 [35] | 3 | 2 | 1 | 2 | 1 | 2 | Satisfactory |
Baban, 2016 [36] | 1 | 1 | 1 | 3 | 1 | 2 | Satisfactory |
Ingvarsson, 2016 [37] | 3 | 2 | 3 | 2 | 2 | 2 | Satisfactory |
Ricento, 2013 [38] | 2 | 1 | 1 | 1 | 1 | 1 | Weak |
Stewart, 2015 [39] | 3 | 3 | 2 | 3 | 2 | 2 | Satisfactory |
Hynes, 2009 [40] | 3 | 2 | 1 | 3 | 3 | 2 | Satisfactory |
Barnes,2001 [41] | 3 | 2 | 3 | 3 | 1 | 3 | Excellent |
Hagelund, 2009 [42] | 1 | 2 | 2 | 2 | 1 | 2 | Weak |
Shindo, 2009 [43] | 1 | 1 | 1 | 2 | 1 | 1 | Weak |
Horst, 2013 [44] | 3 | 1 | 1 | 3 | 1 | 2 | Weak |
Neudorf, 2016 [45] | 2 | 2 | 1 | 2 | 2 | 2 | Weak |
Valtonen, 1998 [46] | 2 | 3 | 2 | 3 | 1 | 3 | Excellent |
Valtonen, 1999 [47] | 3 | 3 | 2 | 3 | 1 | 3 | Excellent |
Fozdar, 2011 [48] | 3 | 1 | 3 | 2 | 2 | 2 | Satisfactory |
Ramaliu, 2003 [52] | 1 | 1 | 1 | 2 | 1 | 1 | Weak |
Abraham, 2004 [53] | 1 | 1 | 1 | 3 | 1 | 2 | Satisfactory |
Preston, 1992 [54] | 2 | 1 | 1 | 2 | 1 | 1 | Weak |
Gil-Garcia, 2015 [56] | 3 | 1 | 1 | 2 | 1 | 2 | Weak |
Gerber, 2017 [57] | 3 | 3 | 3 | 3 | 3 | 3 | Excellent |
Hope, 2011 [58] | 3 | 2 | 1 | 2 | 1 | 2 | Satisfactory |
Marsh, 2012 [59] | 3 | 3 | 2 | 2 | 1 | 3 | Satisfactory |
Pugh, 2017 [60] | 1 | 1 | 1 | 2 | 1 | 1 | Weak |
Naidoo, 2009 [61] | 3 | 3 | 2 | 3 | 1 | 3 | Excellent |
Earnest, 2015 [62] | 3 | 3 | 3 | 3 | 1 | 3 | Excellent |
Barnes, 2007 [63] | 3 | 3 | 2 | 3 | 3 | 3 | Excellent |
Dandy, 2013 [64] | 3 | 3 | 3 | 3 | 2 | 3 | Excellent |
Evans, 2011 [65] | 1 | 1 | 1 | 1 | 2 | 2 | Weak |
Yelland, 2014 [68] | 3 | 3 | 2 | 2 | 1 | 2 | Satisfactory |
Lazar, 2013 [69] | 3 | 3 | 3 | 2 | 1 | 3 | Satisfactory |
Conviser, 2007 [70] | 1 | 1 | 1 | 1 | 2 | 1 | Weak |
Cheng, 2015 [71] | 1 | 1 | 1 | 3 | 2 | 2 | Satisfactory |
Pejic, 2017 [72] | 2 | 1 | 1 | 2 | 1 | 1 | Weak |
Worabo, 2017 [73] | 2 | 1 | 1 | 2 | 1 | 2 | Satisfactory |
Lindgren, 2004 [74] | 3 | 2 | 2 | 2 | 2 | 2 | Satisfactory |
Riggs, 2015 [75] | 3 | 3 | 2 | 2 | 3 | 3 | Satisfactory |
Al-Ali, 2001 [77] | 1 | 1 | 1 | 3 | 1 | 2 | Satisfactory |
Bloemraad, 2005 [78] | 2 | 2 | 2 | 2 | 1 | 2 | Satisfactory |
Casier, 2010 [79] | 2 | 2 | 2 | 2 | 1 | 2 | Satisfactory |
Casier, 2011 [80] | 1 | 2 | 2 | 1 | 1 | 1 | Weak |
Weng, 2016 [81] | 1 | 1 | 1 | 2 | 1 | 1 | Weak |
Fox, 2012 [82] | 2 | 3 | 3 | 3 | 1 | 2 | Satisfactory |
Hein, 2014 [83] | 1 | 3 | 3 | 1 | 1 | 2 | Satisfactory |
Makhoul, 2009 [84] | 3 | 3 | 2 | 2 | 1 | 3 | Satisfactory |
Achilli, 2014 [85] | 1 | 1 | 1 | 1 | 1 | 1 | Weak |
Rosso, 2016 [86] | 3 | 3 | 1 | 3 | 2 | 3 | Satisfactory |
Østergaard-Nielsen, 2001 [88] | 1 | 1 | 1 | 2 | 1 | 1 | Weak |
Rivetti, 2013 [89] | 3 | 2 | 1 | 3 | 2 | 2 | Satisfactory |
Grossman, 2014 [90] | 1 | 1 | 1 | 3 | 1 | 1 | Weak |
Matthews, 2008 [91] | 3 | 2 | 1 | 2 | 1 | 2 | Satisfactory |
Eggert, 2015 [92] | 2 | 1 | 2 | 3 | 1 | 2 | Satisfactory |
Whiteford, 2007 [93] | 1 | 1 | 1 | 1 | 1 | 1 | Weak |
Stack, 2009 [94] | 2 | 3 | 2 | 3 | 2 | 2 | Satisfactory |
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First Author, Year | Country of Origin and Host Country (n) | Social Participation Domain | Mental Health Domain | Method Used for Assessment |
---|---|---|---|---|
Khawaja, 2006 [19] | Origin: Palestinians Host: Jordan (n) 1615 | Community organized groups: Ethnic communities | Psychological distress and Psychological well-being | Survey |
Brown, 2011 [32] | Origin: Liberia Host: USA (n) 25 | Regulatory frameworks, conditions and initiatives: Legal status AND Established societal organizations: Financial transactions | Psychosocial well-being | Participant observation |
Da Lomba, 2010 [33] | Origin: not spec. Host: Great Britain (n) not spec. | Regulatory frameworks, conditions and initiatives: Legal status and Reception systems AND Established societal organizations: Education | - | Document analysis |
Korac, 2003 [34] | Origin: Former Yugoslavia Host: Italy; Netherlands (comparison) (n) 60 | Regulatory frameworks, conditions and initiatives: Legal status and Reception systems AND Established societal organizations: Financial transactions | Psychosocial well-being and Psychological distress | Interviews |
Stewart, 2014 [35] | Origin: various nationalities, 23 in total Host: Scotland (n) 30 | Regulatory frameworks, conditions and initiatives: Legal status AND Established societal organizations: Financial transactions and Labor market and Education | Psychological distress | Interviews. |
Baban, 2016 [36] | Origin: Syria Host: Turkey (n) 30 | Regulatory frameworks, conditions and initiatives: Legal status AND Established societal organizations: Labor market and Financial transactions and Education and Healthcare | - | Interviews and participant observation |
Ingvarsson, 2016 [37] | Origin: Afghanistan, Iran and Iraq Host: Iceland (n) 9 | Regulatory frameworks, conditions and initiatives: Legal status and Reception systems AND Established societal organizations: Labor market; Financial transactions AND Community organized groups: Sports and leisure | Psychosocial well-being and Psychological distress | Semi-structured interviews |
Ricento, 2013 [38] | Origin: Colombia Host: Canada (n) 1 | Regulatory frameworks, conditions and initiatives: Reception systems AND Established societal organizations: Labor market and Education | Psychological distress and Psychosocial well-being | Interview, case study |
Stewart, 2015 [39] | Origin: Sudan and Zimbabwe Host: Canada (n) 85 | Regulatory frameworks, conditions and initiatives: Reception systems | Psychological distress | In-depth interviews |
Hynes, 2009 [40] | Origin: not spec. (15 countries) Host: Great Britain (n) 48 | Regulatory frameworks, conditions and initiatives: Reception systems | Psychological distress | Interviews and focus group discussions |
Barnes, 2001 [41] | Origin: Vietnam Host: Australia (n) 14 | Regulatory frameworks, conditions and initiatives: Legal status and Reception systems AND Established societal organizations: Education | Psychosocial well-being | Semi-structured interviews |
Hagelund, 2009 [42] | Origin: not spec. Host: Norway (n) 344 | Regulatory frameworks, conditions and initiatives: Reception systems AND Established societal organizations: Labor market | - | Survey and in-depth interviews |
Shindo, 2009 [43] | Origin: Kurdish, country not spec. Host: Japan (n) not spec. | Regulatory frameworks, conditions and initiatives: Individual impact | - | Descriptive case study |
Horst, 2013 [44] | Origin: African horn (Kenya) Host: Europe (Norway) (n) not spec. | Regulatory frameworks, conditions and initiatives: Conditions for political engagement AND Community organized groups: Political associations | - | Semi-structured interviews |
Neudorf, 2016 [45] | Origin: not spec. Host: Canada (n) 12 | Established societal organizations: Labor market | - | Semi-structured interviews |
Valtonen, 1998 [46] | Origin: Iran, Iraq and Kuwait Host: Finland (n) 29 | Established societal organizations: Labor market | - | Semi-structured interviews |
Valtonen, 1999 [47] | Origin: Vietnam Host: Finland and Canada (n) 45 | Regulatory frameworks, conditions and initiatives: Reception systems AND Established societal organizations: Labor market AND Community organized groups: Ethnic communities and Religious congregations | - | Semi-structured interviews and participant observation |
Fozdar, 2011 [48] | Origin: Former Yugoslavia (mainly Bosnians), Middle East (mainly Iraqis) and Africa (mainly Somalis and Ethiopians) Host: Australia (n) 150 | Established societal organizations: Labor market | Psychosocial well-being and Psychological well-being | Semi-structured interviews and survey with structured interviews |
Montgomery, 1987 [49] | Origin: Vietnamese Host: Canada (n) 537 | Established societal organizations: Labor market and Financial transactions | - | Survey |
Bach, 1986 [50] | Origin: South-East Asia Host: USA (n) 1500 | Established societal organizations: Labor market | - | Structured telephone interviews |
Caspi, 1998 [51] | Origin: Cambodja Host: USA (n) 161 | Established societal organizations: Labor market AND Community organized groups: Religious congregations | Psychological distress and Psychiatric disorders | Interviews and survey |
Ramaliu, 2003 [52] | Origin: not spec. Host: Canada (n) not spec. | Established societal organizations: Financial transactions and Labor market and Healthcare | Psychological distress | Document analysis |
Abraham, 2004 [53] | Origin Sri Lanka (Tamil) and Caribbean Host: Canada(n) not spec | Established societal organizations: Financial transactions AND Community organized groups: Ethnic communities and Sports and leisure | - | Unstructured interviews, literature |
Preston, 1992 [54] | Origin: Melanesia, Iran Jaya/Indonesia—Melanesia Western Papua Host: Papa New Guinea (n) not spec. | Established societal organizations: Healthcare and Financial transactions | - | Interviews and document analysis |
Thanh Van, 1987 [55] | Origin: Vietnam Host: USA (n) 160 | Established societal organizations: Financial transactions and Education AND Community organized groups: Ethnic communities | Psychosocial well-being and Psychological well-being | Survey |
Gil-Garcia Ó, 2016 [56] | Origin: Guatemala Host: Mexico (n) 148 | Established societal organizations: Financial transactions | - | Participant observation, structured and semi-structured interviews |
Gerber, 2017 [57] | Origin: Nepal (Bhutanese) Host: USA (n) 50 | Established societal organizations: Education and Healthcare | Psychological distress and Psychosocial well-being | Semi-structured interviews and quantitative data |
Hope, 2011 [58] | Origin: not spec. - broad Host: Great Britain (n) not spec. | Established societal organizations: Education AND Community organized groups: Ethnic communities | Psychosocial well-being and Psychological well-being | Participant observation and interviews |
Marsh, 2012 [59] | Origin: Sierra Leone, Ghana, Croatia, Vietnam and Pakistan Host: Australia (n) not spec. | Established societal organizations: Education AND Community organized groups: Sports and leisure | Psychological well-being | Interviews, focus group discussions and field work |
Pugh, 2017 [60] | Origin: Colombia Host: Ecuador (n) not spec. | Established societal organizations: Education AND Community organized groups: Religious congregations and Sports and leisure | - | Case study, document analysis |
Naidoo, 2009 [61] | Origin: African countries (only spec., Sudan) (n) 37 | Established societal organizations: Education | - | Focus group and semi-structured interviews |
Earnest, 2015 [62] | Origin: Afghanistan, Democratic Republic of Congo, Ethiopia, Sudan, South Sudan, Iraq, Pakistan and Burma Host: Australia (n) not spec. | Established societal organizations: Education and Healthcare AND Community organized groups: Religious congregations and Sports and leisure | Psychosocial well-being and Psychological distress | Individual and focus group interviews and document analysis |
Barnes, 2007 [63] | Origin: Cuba Host: USA (n) 20 | Established societal organizations: Education and Healthcare AND Community organized groups: Ethnic communities and Religious congregations | Psychosocial well-being | Semi-structured interviews |
Dandy, 2013 [64] | Origin: Sudan, Afghanistan, Philippines, Bhutan, Burma, Vietnam, Iraq, Iran, Egypt, (England?) Host: Australia (n) 54 | Regulatory frameworks, conditions and initiatives: Reception systems AND Established societal organizations: Education AND Community organized groups: Ethnic communities andSports and leisure | - | Individual and focus group interviews |
Evans, 2011 [65] | Origin: Africa Host: England (n) 37 | Established societal organizations: Education and Healthcare | Psychological distress | Semi-structured interviews |
Haddad, 2002 [66] | Origin: Palestinians Host: Lebanon (n) 1073 | Established societal organizations: Education | - | Survey |
Aylesworth, 1983 [67] | Origin: Indochina, Vietnam, Laos or Hmong, Kambodja Host: USA (n) 217 | Established societal organizations: Healthcare | Psychological distress | Survey with structured interviews |
Yelland, 2014 [68] | Origin: Afghanistan Host: Australia (n) not spec. | Established societal organizations: Healthcare | Psychological distress and Psychosocial well-being | Interviews |
Lazar, 2013 [69] | Origin: Somalians (patients, not interviewed) Host: USA, Ohio (n) 14 | Established societal organizations: Healthcare | - | Semi-structured interviews |
Conviser, 2007 [70] | Origin: Back, Latino, born in Africa Host: USA (n) not spec. | Established societal organizations: Healthcare | - | Interviews and participant observation |
Cheng, 2015 [71] | Origin: Afghanistan Host: Australia (n) not spec. | Established societal organizations: Healthcare | - | Document analysis and expert statement |
Pejic, 2017 [72] | Origin: Somalia Host: USA (n) 1 | Established societal organizations: Healthcare | Psychological distress | Case study |
Worabo, 2017 [73] | Origin: Eritrea Host: USA (n) 15 | Established societal organizations: Healthcare | Psychological distress and Psychological well-being and Psychosocial well-being | Focus group interviews (secondary data) |
Lindgren, 2004 [74] | Origin: Afghans Host: USA, California (n) 5 | Established societal organizations: Healthcare | Psychological well-being | Semi-structured interviews |
Riggs, 2015 [75] | Origin: Afghanistan Host: Australia (n) 30 | Established societal organizations: Healthcare | Psychological distress and Psychosocial well-being | Interviews |
Hitch, 1980 [76] | Origin: Polish, Ukraine and Russian (n) 1164 | Established societal organizations: Healthcare | Psychiatric disorders | Healthcare data |
Al-Ali, 2001 [77] | Origin: Indochina, Vietnam, Laos or Hmong, Kambodja Host: USA (n) 217 | Community organized groups: Ethnic communities | - | Participant observation and semi-structured interviews |
Bloemraad, 2005 [78] | Origin: Vietnam and Portuguese (Azorean) Host: USA and Canada (n) 147 | Established societal organizations: Financial transactions AND Community organized groups: Ethnic communities and Religious congregations | - | Interviews and document analysis |
Casier, 2010 [79] | Origin: Kurdish Host: Belgium and Turkey, EU (n) not spec. | Community organized groups: Ethnic communities and Political associations | - | Participant observation and semi-structured interviews |
Casier, 2011 [80] | Origin: Turkey (Kurdish) Host: Belgium (n) not spec. | Community organized groups: Ethnic communities and Political associations | - | Semi-structured interviews |
Weng, 2016 [81] | Origin: Asia, Africa, Caribbean, majority from Sudan Host: USA (n) 54 | Community organized groups: Ethnic communities | - | Semi-structured interviews |
Fox, 2012 [82] | Origin: Rwanda Host: USA (n) 14 | Community organized groups: Religious congregations | Psychosocial well-being and Psychological well-being | Semi-structured interviews |
Hein, 2014 [83] | Origin: Laos (Hmong) Host: USA | Community organized groups: Ethnic communities | - | Interviews |
Makhoul, 2009 [84] | Origin: Palestinians Host: Lebanon (n) 1335 | Community organized groups: Sports and leisure | Psychological distress and Psychiatric disorders and Psychological well-being | Survey and focus group interviews |
Achilli, 2014 [85] | Origin: Palestinian Host: Jordan (n) not spec. | Community organized groups: Sports and leisure and Political associations | - | Participant observation, semi- and unstructured interviews |
Rosso, 2016 [86] | Origin: various Host: Australia (n) 152 | Community organized groups: Sports and leisure | - | Survey and semi-structured interviews |
Jeong, 2016 [87] | Origin: North Korea Host: South Korea (n)151 | Community organized groups: Political associations | - | Survey |
Østergaard-Nielsen, 2001 [88] | Origin: Turkey(/Kurdistan) Host: Germany and Netherlands (n) not spec. | Community organized groups: Ethnic communities and Political associations | - | Document analysis |
Rivetti, 2013 [89] | Origin: Iran Host: Italy and Turkey (n) 52 | Community organized groups: Political associations | - | Participant observation and semi-structured interviews |
Grossmann, 2014 [90] | Origin: European Judes Host: USA (n) not spec. | Regulatory frameworks, conditions and initiatives | Psychosocial well-being and Psychological well-being | Narrative interviews |
Matthews, 2008 [91] | Origin: Africa, Middle East Host: Australia (n) not spec. | Established societal organizations: Education | Psychosocial well-being and Psychological well-being | Semi-structured interviews |
Eggert, 2015 [92] | Origin: not spec. Host: USA (n) not spec. | Established societal organizations: Healthcare | Psychological well-being | Survey, interviews and participant observation |
Whiteford, 2007 [93] | Origin: Albania Host: Makedonia (n) not spec. | Community organized groups | Psychological distress and Psychological well-being | Refugee camp |
Stack, 2009 [94] | Origin: Afghanistan Host: Canada (n) 11 | Community organized groups: Sports and leisure | Psychological distress | Semi-structured interviews |
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Niemi, M.; Manhica, H.; Gunnarsson, D.; Ståhle, G.; Larsson, S.; Saboonchi, F. A Scoping Review and Conceptual Model of Social Participation and Mental Health among Refugees and Asylum Seekers. Int. J. Environ. Res. Public Health 2019, 16, 4027. https://doi.org/10.3390/ijerph16204027
Niemi M, Manhica H, Gunnarsson D, Ståhle G, Larsson S, Saboonchi F. A Scoping Review and Conceptual Model of Social Participation and Mental Health among Refugees and Asylum Seekers. International Journal of Environmental Research and Public Health. 2019; 16(20):4027. https://doi.org/10.3390/ijerph16204027
Chicago/Turabian StyleNiemi, Maria, Hélio Manhica, David Gunnarsson, Göran Ståhle, Sofia Larsson, and Fredrik Saboonchi. 2019. "A Scoping Review and Conceptual Model of Social Participation and Mental Health among Refugees and Asylum Seekers" International Journal of Environmental Research and Public Health 16, no. 20: 4027. https://doi.org/10.3390/ijerph16204027
APA StyleNiemi, M., Manhica, H., Gunnarsson, D., Ståhle, G., Larsson, S., & Saboonchi, F. (2019). A Scoping Review and Conceptual Model of Social Participation and Mental Health among Refugees and Asylum Seekers. International Journal of Environmental Research and Public Health, 16(20), 4027. https://doi.org/10.3390/ijerph16204027