Factors Associated with Anxiety, Depression, and Stress in Peruvian University Students during the COVID-19 Pandemic
by
, , and
Palmer J. Hernández-Yépez
1
,
Carlos O. Muñoz-Pino
1,
Valeria Ayala-Laurel
1
,
Pavel J. Contreras-Carmona
1,
Fiorella Inga-Berrospi
1,
Víctor J. Vera-Ponce
2,3,
Virgilo E. Failoc-Rojas
4,*,
César Johan Pereira-Victorio
5,* and
Mario J. Valladares-Garrido
1,6,*
1
South American Center for Education and Research in Public Health, Universidad Norbert Wiener, Lima 15046, Peru
2
Instituto de Investigación en Ciencias Biomédicas, Universidad Ricardo Palma, Lima 15039, Peru
3
Universidad Tecnológica del Perú, Lima 15046, Peru
4
Research Unit for Generation and Synthesis Evidence in Health, Universidad San Ignacio de Loyola, Lima 15024, Peru
5
School of Medicine, Universidad Continental, Lima 15046, Peru
6
Oficina de Epidemiología, Hospital Regional Lambayeque, Chiclayo 14012, Peru
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2022, 19(21), 14591; https://doi.org/10.3390/ijerph192114591
Submission received: 14 September 2022
/
Revised: 14 October 2022
/
Accepted: 25 October 2022
/
Published: 7 November 2022
(This article belongs to the Special Issue Emotion Regulation and COVID-Related Stress Management)
Abstract
:During the COVID-19 pandemic, university students have adopted measures that completely transformed their educational environment, and this has generated an increase in psychological stress. The present study aimed to identify the factors associated with anxiety, depression, and stress in students at a university in Peru during the COVID-19 pandemic in 2020. We conducted a cross-sectional analytical study in students in Lima, Peru. The DASS-21 scale was used to measure levels of depression, anxiety, and stress and associate it with socio-educational and COVID-19-related variables using generalized linear models with Poisson distribution, log link, and robust variance. Of 400 students surveyed, 19.2%, 23.2% and 17.2% of students presented depression, anxiety, and stress, respectively. The frequency of depression (PR = 0.91, 95%CI: 0.84–0.99), anxiety (PR = 0.90, 95%CI: 0.83–0.99) and stress (PR = 0.92, 95%CI: 0.86–0.99) was lower in women. The students of the engineering and business faculty presented a higher frequency of anxiety (PR = 1.11, 95%CI: 1.00–1.22). There was a greater frequency of presenting anxiety, depression and stress in students who worked in a different area of health or did not work. Our results suggest the importance of promoting mental health awareness campaigns in university students due to the constant academic load they have.
1. Introduction
The COVID-19 pandemic represents a global health crisis [1]. By September 2020, when this study was conducted, more than 32 million confirmed cases and 990,000 deaths had been reported worldwide [2], while in Latin America the prevalence of COVID-19 had been estimated at 9 million cases and more than 300,000 deaths [3]. The pandemic has highlighted the mental health of the population. Previous studies estimate a 29% prevalence of anxiety due to COVID-19 in the university population [4], while in Latin America a percentage of 33% anxiety has been described [5].
Mental health in the university population is a topic of great interest since university students find themselves in an environment of constant anxiety and stress [6]. The current pandemic has importantly affected the university population, as students have had to adopt measures that completely transform their educational environment. Although previous research has been carried out on the impact on the mental health of university students during the pandemic [7,8], most have been conducted during the first months of the pandemic and have focused on evaluating depression or anxiety and their associated factors [9,10], without considering academic and clinical variables, which our study attempts to evaluate. Additionally, other studies have focused specifically on medical students and have not evaluated the impact of COVID-19 on the mental health of students in other majors [11,12]. Our research is relevant because it considers students from different faculties and delves into sociodemographic, academic, and clinical variables.
For these reasons, there is an urgent need to assess the effects of the pandemic on the mental health and well-being of university students. The present study aimed to identify the factors associated with anxiety, depression, and stress in students at a university in Peru during the COVID-19 pandemic in 2020.
2. Materials and Methods
2.1. Study Design
We conducted an observational, cross-sectional analytical study during the second academic semester of the year 2020 between the months of September and December at the Universidad Norbert Wiener in Lima, Peru.
2.2. Population and Sample
The population consisted of students who attended the 2020-II semester of the faculties of Health Sciences, Law and Political Science, and Engineering and Business of the Universidad Norbert Wiener, which had 6054, 608 and 1563 students, respectively. The sample size was calculated with OpenEpi v.3.01 program applying Fisher’s formula for finite populations, resulting in a sample size of 370 people with a confidence level of 95%. A stratified probabilistic sampling was carried out for each faculty selected for the study. The sample calculated for each faculty was determined in 273, 27 and 70 for the faculties of Health Sciences, Law and Political Sciences and Engineering and Business, respectively.
Students who were enrolled in the 2020-II academic semester and completed the variables of interest were included. Students who did not agree to voluntarily participate in the study were excluded.
2.3. Instrument
We used the depression, anxiety, and stress scale (DASS-21). This scale has been validated in Peru for multiple studies in university students [13,14]. The DASS-21 scale consists of 21 items and evaluates the three variables (depression, anxiety, and stress) independently with seven questions for each one using a Likert-type scale with four options: never = 0; sometimes = 1; often = 2; almost always = 3. The results are classified as follows: (a) normal (<5 points), (b) mild (5–6 points), (c) moderate (7–10 points), (d) severe (11–13 points), (e) extremely severe (>14 points). For purposes of this study, the responses were dichotomized into (a) did not present (when the result was normal); (b) it did present (when the result was mild, moderate, severe, and extremely severe).
2.4. Variables
The dependent variable was the presence of depression, anxiety, and stress, which was measured operationally with the DASS-21 scale explained above.
The independent variables were the socio-educational data: age (in years), sex (male, female), marital status (single, cohabiting, married, divorced, widowed), relatives with whom they live (accompanied, alone) and having children (no, yes), career (health sciences, engineering, business, law and political science), academic year (general studies and college studies), previous career (no, yes), current type of work (no, related to health, not related to health). Additionally, the students were asked if they had been diagnosed with COVID-19 and if any family member or close friend had been diagnosed with COVID-19.
2.5. Study Procedure
The instrument was applied virtually due to social restrictions of COVID-19 pandemic. The survey was applied through Google Forms to the students of the Universidad Norbert Wiener during the second semester of the year 2020. Before the survey was carried out, they were asked to accept an informed consent for their participation in the research. During the entire execution of the study, the autonomy and anonymity of the participants were respected; in the same way, the confidentiality of the results obtained from the applied survey was guaranteed. A database was generated in a spreadsheet in Microsoft Excel program and those records that did not answer the questions with the variables of interest were eliminated from the database, which were 8 records.
2.6. Statistical Analysis
All statistical analyses were performed using Stata 15.0. The descriptive analysis was carried out using frequencies and percentages. For the quantitative variable age, mean and standard deviation were reported. We performed a bivariate analysis to estimate the association between depression, anxiety, and stress with sociodemographic, professional, and clinical variables of the students. Subsequently, we carried out a simple and multiple regression analysis to investigate the factors independently associated with depression, anxiety, and stress, using generalized linear models, Poisson distribution family and log link function with robust variance. Prevalence ratios and 95% confidence intervals were estimated.
2.7. Ethical Considerations
This study was reviewed and approved by the ethics committee of the Universidad Norbert Wiener, with file No. 078-2020. The surveys were anonymous, and codes were used to maintain confidentiality in the database obtained. Informed consent was given to each research participant.
3. Results
Table 1 shows the sociodemographic, academic, and clinical data of the students. The number of students surveyed was 400 students. 58.8% were found to be female and the average age was 24.5 years. More than half (73.0%) reported studying a career belonging to the Faculty of Health Sciences. 24.8% claimed to have been diagnosed with COVID-19. Regarding the DASS-21, 19.2%, 23.2% and 17.2% of students presented depression, anxiety, and stress; respectively.
Table 2 shows the bivariate analysis, where a significant association was found between sex (p < 0.001), type of work (p < 0.001), and diagnosis of COVID-19 (p < 0.001) with the three analyzed variables of the DASS-21 (depression, anxiety, stress). A significant association was also found between the career studied and anxiety and stress (p = 002; p = 0.016, respectively).
Table 3 shows the simple regression analysis. The frequency of having depression, anxiety and stress was lower in women by 20% (PR = 0.80, 95%CI: 0.73–0.88), 21% (PR = 0.79, 95%CI: 0.71–0.88) and 19% (PR = 0.81, 95%CI: 0.75–0.88); respectively. Likewise, students who belonged to the engineering and business faculty had a higher frequency of having depression, anxiety and stress in 15% (PR = 1.15, 95%CI: 1.04–1.26), 23% (PR = 1.23, 95%CI: 1.11–1.37), and 15% (PR = 1.15, 95%CI: 1.05–1.25), respectively, when compared to health sciences students. In addition, those students who worked in a different health area or did not work, those who were not diagnosed with COVID-19 and those who did not have a relative diagnosed with COVID-19 presented a higher frequency of having depression, anxiety and stress.
Table 4 shows the multiple regression analysis. The association of lower frequency to having depression, anxiety and stress in women was maintained; 9% (PR = 0.91, 95%CI: 0.84–0.99), 10% (PR = 0.90, C95%I: 0.83–0.99), 8% (PR = 0.92, 95%CI: 0.86–0.99), respectively. In the students of the engineering and business faculty, the frequency of presenting greater anxiety was only maintained at 11% (PR = 1.11, 95%CI: 1.00–1.22). Likewise, the association was maintained to present greater anxiety, depression and stress in those students who worked in a different health area or did not work, and those who were not diagnosed with COVID-19.
4. Discussion
Although previous research has been carried out on the impact on the mental health of university students during the pandemic [7,8], most have been conducted during the first months of the pandemic and have focused on evaluating depression or anxiety and their associated factors [9,10], without considering academic and clinical variables, which our study attempted to evaluate. Additionally, other studies have focused specifically on medical students and have not evaluated the impact of COVID-19 on the mental health of students in other majors [11,12]. Our research is relevant because it considered students from different faculties and delved into sociodemographic, academic, and clinical variables.
4.1. Prevalence of Mental Health Disorders
In the present investigation we found that 19.2% of the students presented depression. This is similar to the results of the study by Yusvisaret et al. (2021), who reported that 17% of students had depression in a private university in Mexico [15]. However, it differs from the result reported by Huarcaya-Victoria et al. (2021) who in their study of Peruvian university students reported levels of up to 74% of depression among students [16]. The prevalence found could be explained because our study was carried out in a city that presented high mortality from COVID-19 (approximately fifty thousand deaths by that date), which is a potential reason for the depression incidence [17]. Another possible explanation is due to periods of social distancing and isolation, which could influence the appearance of symptoms of depression [18]. Finally, the use of other scales (Zung, PHQ-9), may have provided different results.
We found that 23.2% of students presented anxiety. The findings correlate with the study by Chávez-Márquez (2021) who found a 30% prevalence of anxiety in students at a university in Mexico during the COVID-19 pandemic [19]. However, our result is lower than that reported by Saravia-Bartra et al. (2020), who in their study of medical students in Peru found that 75.4% manifested some degree of anxiety [20]. It is worth noting that this study was conducted during the first half of 2020, months in which the pandemic had just begun and the highest mortality rates in the country were recorded; while our study was carried out during the last months of the year 2020 when the contagion numbers had decreased, and vaccines were on the horizon. Likewise, the anxiety figure found in our research could also be explained due to the use of a different scale than the previous works (i.e., the GAD-7 scale) and the virtuality of the education process, which meant a process of change and adaptation for the students [21].
17.2% of the students surveyed presented stress. This is similar to the findings of Virto-Farfan et al. (2021) who reported a prevalence of stress in 15% of university students in Peru [22]. However, this result is lower than that documented by Luque-Vilca et al. (2022) who found that 92% of university students presented academic stress during the semester of study [23]. This is explained due to the various stress factors that intervene in the health of students, especially the overload of assignments and projects, which students must submit by a set deadline. Added to this is the abrupt change to on-line learning, which represents an additional stress for students due to the adaptation to this new modality.
4.2. Factors Associated with Mental Health Disorders
Women had a lower frequency of depression, anxiety, and stress. Although various studies show that women have a higher prevalence of depression, anxiety, and stress than men [24,25], the data regarding university students in the context of COVID-19 are not conclusive [26]. Our results differ from those reported by Soto-Rodriguez et al. (2021) who in their study showed that women had a higher prevalence of symptoms such as depression and anxiety during the pandemic [27]. This sex-related association could be explained by biological, hormonal, and psychosocial factors which explain the higher prevalence of these symptoms compared to men [28].
Likewise, the students of the engineering and business faculty had a higher frequency of anxiety. The findings correlate with the study by Siddiqui et al. (2020) who found that engineering students had a higher prevalence of symptoms of anxiety and depression compared to medical students [29]. However, it differs with various studies that conclude that medical students experience greater anxiety, unlike other careers [30,31]. Although it has been shown that health sciences students are more educated regarding viral pandemics and health concerns than other careers [32], which could reduce symptoms of anxiety and depression [33,34], the COVID pandemic has affected to students of all careers alike, due to the suspension of classes and face-to-face practices, social isolation and adaptation to the virtual education and learning process [35]. An additional explanation for this result may be due to variables such as preconceptions, fear or lived experiences rather than the educational career; however, these variables were not measured in our study.
Students who worked in an area other than health or did not work presented a higher frequency of depression, anxiety and stress compared to those who worked in a health-related area. This result differs from most research which focuses on health care personnel and finds a high prevalence of these three symptoms [36,37], which is explained by the high level of physical and psychological exhaustion due to work overload during the COVID-19 pandemic as the first line of response and by the latent risk of contagion [38,39]. However, most of these studies were conducted during the first months of the pandemic, when the number of deaths was high; in addition, the present investigation did not measure whether those who worked in a health-related area were necessarily on the front line attending COVID-19 cases.
In our study, we found that students who lived alone had a 27% lower frequency of anxiety compared to those who lived with others. This finding is similar to the study by Fingerman et al. (2021), who found that living alone was associated with positive emotions, which is explained by a decreased fear of infecting family and friends [40]. However, it differs from that reported by Marmet et al. (2021) & Raj et al. (2021), who found in their studies symptoms of psychological trauma, anxiety, depression, and decreased sleep in those people who lived alone during the pandemic period. This is consisted with the negative impact of isolation on mental health and by the perceived financial vulnerability of the study population [41,42].
Students who had been diagnosed with COVID-19 had a higher frequency of depression, anxiety, and stress. This finding correlates with the studies by Sher (2021) and Deng et al. (2020), who in their research found a high prevalence of symptoms related to depression and anxiety, which is likely the result of the stress experienced during the period of infection and by the long-term complications that may be triggered [43,44]. However, recent studies report a lower frequency of these symptoms in patients who had COVID-19, and this is possibly the product of two main factors; firstly, knowledge about the disease and secondly, a decreased risk perception resulting from the vaccination campaign [45,46]. Interestingly, at the time of execution of our study, the vaccination process had not yet started; yet, a growing body of knowledge of vaccines to combat COVID-19 was available and could have lessened some anxiety as well. This assumption should be addressed in detail measuring questions on vaccination and how this influenced on mental status.
There are other factors that may influence the development of mental disorders in university students. For example, further aspects such as stress level of studies [1], delay of studies due to the pandemic [2], or stressful thoughts regarding further waves of the pandemic [3]. These conditions may have increased the risk of mental disorders in some individuals compared to others. For this reason, it would be necessary to approach how the pandemic have affected long-term outcomes in education, such as academic performance and student burnout.
4.3. Limitations and Strenghts
The results of our study need to be placed in proper context and cautiously extrapolated and analyzed accordingly as there are both strengths and weaknesses in the data. First, as it is a cross-sectional study, causal relationships between the variables of interest evaluated cannot be affirmed. Second, the findings cannot be inferred to the entire population of university students, since they correspond to an analysis of only one university campus; therefore, selection bias could exist and, in addition, the population of this study was heterogeneous; consequently, extrapolations of the results should be carefully analyzed. Third, it was not possible to evaluate other variables that influence the development of mental health disorders in university students such as alcohol use, drug use, previous traumas or mental disorders, use of antidepressants and anti-anxiety drugs, income level, etc., which could lead to probable measurement bias. However, the main strength lies in the use of the DASS-21 instrument, which has adequate psychometric properties. This scale has been validated in Peru for multiple studies in university students [13,14], and, although it is not designed for diagnostic purposes, its use may help to understand how many students may potentially develop mental disorders. Another strength is that we included university students not only from health areas, which provides solid evidence on the impact of the COVID-19 pandemic on the mental health of university students from many different disciplines.
5. Conclusions
The association to present depression, anxiety and stress was lower in female students, while this frequency was higher in students who worked in a different area of health or did not work, and those who were not diagnosed with COVID-19. The students of the engineering and business faculty only had a higher frequency to present anxiety, but not depression and stress. Our results suggest the importance of promoting mental health awareness campaigns in university students due to the constant academic load they have.
Author Contributions
Conceptualization, P.J.H.-Y., C.O.M.-P., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; methodology, P.J.H.-Y., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; software, P.J.H.-Y., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; validation, P.J.H.-Y., C.O.M.-P., V.A.-L., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; formal analysis, P.J.H.-Y., C.O.M.-P., V.A.-L., P.J.C.-C., F.I.-B., C.J.P.-V. and M.J.V.-G.; resources, P.J.H.-Y., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; data curation, P.J.H.-Y., F.I.-B., V.J.V.-P., C.J.P.-V. and M.J.V.-G.; writing—original draft preparation, P.J.H.-Y., C.O.M.-P., V.A.-L., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; writing—review and editing, P.J.H.-Y., C.O.M.-P., V.A.-L., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; visualization, P.J.H.-Y., C.O.M.-P., V.A.-L., P.J.C.-C., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G.; supervision, P.J.H.-Y. and M.J.V.-G.; project administration P.J.H.-Y., F.I.-B. and M.J.V.-G.; funding acquisition, P.J.H.-Y., F.I.-B., V.J.V.-P., V.E.F.-R., C.J.P.-V. and M.J.V.-G. All authors have read and agreed to the published version of the manuscript.
Funding
This research was funded by Norbert Wiener Private University, grant number 078-2020 and the APC was funded by Norbert Wiener Private University.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Norbert Wiener University (UPNW). Reference: Exp. No. 078-2020, approved on 6 July 2020.
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
The dataset generated and analyzed during the current study is not publicly available because the ethics committee has not provided permission/authorization to publicly share the data but are available from the corresponding author on reasonable request.
Acknowledgments
M.J.V.-G. was supported by the Fogarty International Center of the National Institutes of Mental Health (NIMH) under Award Number D43TW009343 and the University of California Global Health Institute (UCGHI).
Conflicts of Interest
The authors declare no conflict of interest.
References
- Pollard, C.A.; Morran, M.P.; Nestor-Kalinoski, A.L. The COVID-19 pandemic: A global health crisis. Physiol. Genom. 2020, 52, 549–557. [Google Scholar] [CrossRef] [PubMed]
- Zheng, C.; Shao, W.; Chen, X.; Zhang, B.; Wang, G.; Zhang, W. Real-world effectiveness of COVID-19 vaccines: A literature review and meta-analysis. Int. J. Infect. Dis. 2021, 114, 252–260. [Google Scholar] [CrossRef]
- Anaya-Covarrubias, J.Y.; Pizuorno, A.; Mirazo, S.; Torres-Flores, J.; Du Pont, G.; Lamoyi, E.; Fierro, N.A. COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection. Curr. Opin. Pharmacol. 2022, 63, 102203. [Google Scholar] [CrossRef] [PubMed]
- Wang, C.; Wen, W.; Zhang, H.; Ni, J.; Jiang, J.; Cheng, Y.; Zhou, M.; Ye, L.; Feng, Z.; Ge, Z.; et al. Anxiety, depression, and stress prevalence among college students during the COVID-19 pandemic: A systematic review and meta-analysis. J. Am. Coll. Health 2021, 1–8. [Google Scholar] [CrossRef] [PubMed]
- Palomera-Chavez, A.; Herrero, M.; Carrasco-Tapias, N.E.; Juárez-Rodríguez, P.; Barrales-Díaz, C.R.; Hernández-Rivas, M.I.; Abreu, M.d.C.L.; Montenegro, L.L.; Meda-Lara, R.M.; Moreno-Jiménez, B. Psychological impact of the COVID-19 pandemic on five Latin American countries. Rev. Latinoam. Psicol. 2021, 53, 83–93. [Google Scholar]
- Bruffaerts, R.; Mortier, P.; Kiekens, G.; Auerbach, R.P.; Cuijpers, P.; Demyttenaere, K.; Green, J.G.; Nock, M.K.; Kessler, R.C. Mental health problems in college freshmen: Prevalence and academic functioning. J. Affect. Disord. 2018, 225, 97–103. [Google Scholar] [CrossRef] [Green Version]
- Kaparounaki, C.K.; Patsali, M.E.; Mousa, D.-P.V.; Papadopoulou, E.V.; Papadopoulou, K.K.; Fountoulakis, K.N. University students’ mental health amidst the COVID-19 quarantine in Greece. Psychiatry Res. 2020, 290, 113111. [Google Scholar] [CrossRef]
- Son, C.; Hegde, S.; Smith, A.; Wang, X.; Sasangohar, F. Effects of COVID-19 on College Students’ Mental Health in the United States: Interview Survey Study. J. Med. Internet Res. 2020, 22, e21279. [Google Scholar] [CrossRef]
- Ettman, C.K.; Abdalla, S.M.; Cohen, G.H.; Sampson, L.; Vivier, P.M.; Galea, S. Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic. JAMA Netw. Open 2020, 3, e2019686. [Google Scholar] [CrossRef]
- Chen, F.; Zheng, D.; Liu, J.; Gong, Y.; Guan, Z.; Lou, D. Depression and anxiety among adolescents during COVID-19: A cross-sectional study. Brain Behav. Immun. 2020, 88, 36–38. [Google Scholar] [CrossRef]
- Chandratre, S. Medical Students and COVID-19: Challenges and Supportive Strategies. J. Med. Educ. Curric. Dev. 2020, 7, 2382120520935059. [Google Scholar] [CrossRef] [PubMed]
- Ruvalcaba, P.K.A.; González, R.L.P.; Jiménez, Á.J.M. Depression and anxiety in Med students during isolation for COVID-19 pandemic. Investig. Educ. Médica 2021, 10, 52–59. [Google Scholar]
- Vilchez-Cornejo, J.; Quiñones-Laveriano, D.; Failoc-Rojas, V.; Acevedo-Villar, T.; Larico-Calla, G.; Mucching-Toscano, S.; Torres-Roman, J.S.; Aquino-Núñez, P.T.; La Cruz, J.C.-D.; Rosario, A.H.; et al. Mental health and quality of sleep from eight faculties of medical students in Peru. Rev. Chil. Neuro-Psiquiatr. 2016, 54, 272–281. [Google Scholar] [CrossRef] [Green Version]
- Campos-De La Cruz, I.; Burneo-Ramírez, M.C.; Runzer-Colmenares, F.M. Association between mental health and attitudes towards confinement during the COVID-19 pandemic in hospitals in Lima and Callao. Acta Médica Peru. 2021, 38, 177–185. [Google Scholar]
- Yusvisaret-Palmer, L.; Palmer-Morales, S.; Medina-Ramirez, M.C.R.; López-Palmer, D.A. Prevalence of depression during the COVID-19 in medicine students from a private Mexican university. MEDISAN 2021, 25, 637–646. [Google Scholar]
- Huarcaya-Victoria, J.; Elera-Fitzcarrald, C.; Crisol-Deza, D.; Villanueva-Zúñiga, L.; Pacherres, A.; Torres, A.; Huertas, G.; Calderón, D.; Noriega-Baella, C.; Astonitas, E.; et al. Factors associated with mental health in Peruvian medical students during the COVID-19 pandemic: A multicentre quantitative study. Rev. Colomb. Psiquiatr. 2021, in press. [CrossRef]
- López, M.G.F.; Tarazona, A.S.; De La Cruz-Vargas, J.A. Regional distribution of COVID-19 mortality in Peru. Rev. Fac. Med. Hum. 2021, 21, 326–334. [Google Scholar]
- Tasso, A.F.; Sahin, N.H.; Roman, G.J.S. COVID-19 disruption on college students: Academic and socioemotional implications. Psychol. Trauma Theory Res. Pract. Policy 2021, 13, 9–15. [Google Scholar] [CrossRef]
- Chávez-Márquez, I.L. Anxiety in College Students during the COVID-19 Pandemic: A Quantitative Study. Psicumex 2021, 11, e420. [Google Scholar]
- Saravia-Bartra, M.M.; Cazorla-Saravia, P.; Cedillo-Ramírez, L. Anxiety level of first-year medical students in a private university in Peru during COVID-19. Rev. Fac. Med. Hum. 2020, 20, 568–573. [Google Scholar]
- Chaturvedi, K.; Vishwakarma, D.K.; Singh, N. COVID-19 and its impact on education, social life and mental health of students: A survey. Child. Youth Serv. Rev. 2020, 121, 105866. [Google Scholar] [CrossRef] [PubMed]
- Virto-Farfan, H.; Ccahuana, F.; Loayza-Bairo, W.; Cornejo-Calderón, A.A.; Sanchez, D.; Miguel, C.; Carlos, V.; Gustavo, T. Stress, anxiety and depression in the initial stage of social isolation by COVID-19, Cusco-Perú. Rev. Recien 2021, 10, 5–21. [Google Scholar]
- Luque-Vilca, O.M.; Bolivar-Espinoza, N.; Achahui-Ugarte, V.E.; Gallegos-Ramos, J.R. Academic stress in university students in the face of virtual education associated with COVID-19. PURIQ 2021, 4, 56–65. [Google Scholar]
- Albert, P.R. Why is depression more prevalent in women? J. Psychiatry Neurosci. 2015, 40, 219–221. [Google Scholar] [CrossRef]
- Thibaut, F.; van Wijngaarden-Cremers, P. Women’s Mental Health in the Time of COVID-19 Pandemic. Front. Glob. Women’s Health 2020, 1, 588372. [Google Scholar] [CrossRef]
- Gao, W.; Ping, S.; Liu, X. Gender differences in depression, anxiety, and stress among college students: A longitudinal study from China. J. Affect. Disord. 2019, 263, 292–300. [Google Scholar] [CrossRef]
- Soto-Rodríguez, I.; Zuñiga-Blanco, A. Depression, anxiety and stress of university students in times of COVID-19: Use of the DASS-21 scale. Espíritu Emprend. TES 2021, 5, 45–61. [Google Scholar]
- Dean, J.; Keshavan, M. The neurobiology of depression: An integrated view. Asian J. Psychiatry 2017, 27, 101–111. [Google Scholar] [CrossRef]
- Siddiqui, N.A.; Fatima, S.; Taj, F.B.; Shahid, A.; Moosa, Z.A. Depression among undergraduate medical and engineering students: A comparative study. Pak. J. Med. Sci. 2020, 36, 1096–1099. [Google Scholar] [CrossRef]
- Iorga, M.; Dondas, C.; Zugun-Eloae, C. Depressed as Freshmen, Stressed as Seniors: The Relationship between Depression, Perceived Stress and Academic Results among Medical Students. Behav. Sci. 2018, 8, 70. [Google Scholar] [CrossRef]
- Shao, R.; He, P.; Ling, B.; Tan, L.; Xu, L.; Hou, Y.; Kong, L.; Yang, Y. Prevalence of depression and anxiety and correlations between depression, anxiety, family functioning, social support and coping styles among Chinese medical students. BMC Psychol. 2020, 8, 38. [Google Scholar] [CrossRef] [PubMed]
- Alzoubi, H.; Alnawaiseh, N.; Al-Mnayyis, A.; Abu Lubad, M.; Aqel, A.; Al-Shagahin, H. COVID-19—Knowledge, Attitude and Practice among Medical and Non-Medical University Students in Jordan. J. Pure Appl. Microbiol. 2020, 14, 17–24. [Google Scholar] [CrossRef] [Green Version]
- Khasawneh, A.I.; Abu Humeidan, A.; Alsulaiman, J.W.; Bloukh, S.; Ramadan, M.; Al-Shatanawi, T.N.; Awad, H.H.; Hijazi, W.Y.; Al-Kammash, K.R.; Obeidat, N.; et al. Medical Students and COVID-19: Knowledge, Attitudes, and Precautionary Measures. A Descriptive Study from Jordan. Front. Public Health 2020, 8, 253. [Google Scholar] [CrossRef] [PubMed]
- Adli, I.; Widyahening, I.S.; Lazarus, G.; Phowira, J.; Baihaqi, L.A.; Ariffandi, B.; Putera, A.M.; Nugraha, D.; Gamalliel, N.; Findyartini, A. Knowledge, attitude, and practice related to the COVID-19 pandemic among undergraduate medical students in Indonesia: A nationwide cross-sectional study. PLoS ONE 2022, 17, e0262827. [Google Scholar] [CrossRef] [PubMed]
- Walters, M.; Alonge, T.; Zeller, M. Impact of COVID-19 on Medical Education: Perspectives from Students. Acad. Med. J. Assoc. Am. Med. Coll. 2022, 97, S40–S48. [Google Scholar] [CrossRef] [PubMed]
- Salari, N.; Khazaie, H.; Hosseinian-Far, A.; Khaledi-Paveh, B.; Kazeminia, M.; Mohammadi, M.; Shohaimi, S.; Daneshkhah, A.; Eskandari, S. The prevalence of stress, anxiety and depression within front-line healthcare workers caring for COVID-19 patients: A systematic review and meta-regression. Hum. Resour. Health 2020, 18, 100. [Google Scholar] [CrossRef]
- Lai, J.; Ma, S.; Wang, Y.; Cai, Z.; Hu, J.; Wei, N.; Wu, J.; Du, H.; Chen, T.; Li, R.; et al. Factors Associated with Mental Health Outcomes among Health Care Workers Exposed to Coronavirus Disease. JAMA Netw. Open 2020, 3, e203976. [Google Scholar] [CrossRef]
- Lozano-Vargas, A. Burnout syndrome in health care workers in the COVID-19 pandemic. Rev. Neuropsiquiatr. 2021, 84, 1–2. [Google Scholar] [CrossRef]
- Ruiz-Fernández, M.D.; Ramos-Pichardo, J.D.; Ibáñez-Masero, O.; Cabrera-Troya, J.; Carmona-Rega, M.I.; Ortega-Galán, Á.M. Compassion fatigue, burnout, compassion satisfaction and perceived stress in healthcare professionals during the COVID-19 health crisis in Spain. J. Clin. Nurs. 2020, 29, 4321–4330. [Google Scholar] [CrossRef]
- Fingerman, K.L.; Ng, Y.T.; Zhang, S.; Britt, K.; Colera, G.; Birditt, K.S.; Charles, S.T. Living Alone During COVID-19: Social Contact and Emotional Well-being Among Older Adults. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 2020, 76, e116–e121. [Google Scholar] [CrossRef]
- Marmet, S.; Wicki, M.; Gmel, G.; Gachoud, C.; Daeppen, J.B.; Bertholeta, N.; Studera, J. The psychological impact of the COVID-19 crisis on young Swiss men participating in a cohort study. Swiss Med. Wkly. 2021, 151, w30028. [Google Scholar] [PubMed]
- Raj, T.; Bajaj, A. Living alone in lockdown: Impact on mental health and coping mechanisms among young working adults. Curr. Psychol. 2021, 1–13. [Google Scholar] [CrossRef] [PubMed]
- Sher, L. Post-COVID syndrome and suicide risk. QJM Mon. J. Assoc. Physicians 2021, 114, 95–98. [Google Scholar] [CrossRef] [PubMed]
- Deng, J.; Zhou, F.; Hou, W.; Silver, Z.; Wong, C.Y.; Chang, O.; Huang, E.; Zuo, Q.K. The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: A meta-analysis. Ann. N. Y. Acad. Sci. 2021, 1486, 90–111. [Google Scholar] [CrossRef] [PubMed]
- Yağar, F. Fear of COVID-19 and Its Association With Health Literacy in Elderly Patients. J. Patient Exp. 2021, 8, 23743735211056506. [Google Scholar] [CrossRef]
- Borges, J.; Byrne, M. Investigating COVID-19 risk perception and preventive behaviours in third-level students in Ireland. Acta Psychol. 2022, 224, 103535. [Google Scholar] [CrossRef]
Table 1.
Sociodemographic, academic, and clinical characteristics of the students.
| Characteristics | N (%) |
|---|---|
| Sex | |
| Male | 165 (41.2) |
| Female | 235 (58.8) |
| Age * | 24.5 ± 3.98 |
| Marital status | |
| Non united (single, widowed, divorced) | 378 (94.5) |
| United (married, cohabiting) | 22 (5.5) |
| Faculty | |
| Health sciences | 292 (73.0) |
| Engineering and business | 85 (21.2) |
| Law and political science | 23 (5.8) |
| Previous career | |
| Yes | 93 (23.2) |
| No | 307 (76.8) |
| Academic Year | |
| General studies (1st and 2nd year) | 98 (24.5) |
| Faculty studies (3rd year or more) | 302 (75.5) |
| Type of work | |
| Yes, health related | 48 (12.0) |
| Yes, other than health | 115 (28.8) |
| Does not work | 237 (59.2) |
| With whom do you live? | |
| Accompanied | 374 (93.5) |
| Alone | 26 (6.5) |
| Do you have children? | |
| Yes | 30 (7.5) |
| No | 370 (92.5) |
| Have you been diagnosed with COVID-19? | |
| Yes | 99 (24.8) |
| No | 301 (75.2) |
| Has any family member been diagnosed with COVID-19? | |
| Yes | 265 (66.2) |
| No | 135 (33.8) |
| Depression ** | |
| Yes | 77 (19.2) |
| No | 323 (80.8) |
| Anxiety ** | |
| Yes | 93 (23.2) |
| No | 307 (76.8) |
| Stress ** | |
| Yes | 69 (17.2) |
| No | 331 (82.8) |
* Mean ± standard deviation; ** Obtained by DASS-21.
Table 2.
Factors associated with presenting depression, anxiety, and stress in students of the Universidad Norbert Wiener. Bivariate analysis.
Table 2.
Factors associated with presenting depression, anxiety, and stress in students of the Universidad Norbert Wiener. Bivariate analysis.
| Variables | Depression | p ** | Anxiety | p ** | Stress | p ** | |||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 77) | No (n = 323) | Yes (n = 93) | No (n = 307) | Yes (n = 69) | No (n = 331) | ||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
| Sex | <0.001 | <0.001 | <0.001 | ||||||
| Male | 15 (3.7) | 150 (37.5) | 21 (5.3) | 144 (36.0) | 12 (3.0) | 153 (38.3) | |||
| Female | 62 (15.5) | 173 (43.3) | 72 (18.0) | 163 (40.8) | 57 (14.3) | 178 (44.5) | |||
| Age | 23.1 ± 3.1 | 24.8 ± 4.0 | 0.996 | 23.5 ± 3.6 | 24.8 ± 4.0 | 0.997 | 23.4 ± 3.63 | 24.7 ± 4.0 | 0.994 |
| Marital status | 0.214 | 0.563 | 0.297 | ||||||
| Non united | 75 (18.8) | 303 (75.8) | 89 (22.3) | 289 (72.3) | 67 (16.8) | 311 (77.8) | |||
| United | 2 (0.5) | 20 (5.0) | 4 (1.0) | 18 (4.5) | 2 (0.5) | 20 (5.0) | |||
| Faculty | 0.332 | 0.002 | 0.016 | ||||||
| Health sciences | 65 (16.3) | 227 (56.8) | 81 (20.3) | 211 (52.8) | 60 (15.0) | 232 (58.0) | |||
| Engineering and business | 9 (2.3) | 76 (19.0) | 9 (2.3) | 76 (19.0) | 7 (1.8) | 78 (19.5) | |||
| Law and political science | 3 (0.8) | 20 (5.0) | 3 (0.8) | 20 (5.0) | 2 (0.5) | 21 (5.3) | |||
| Previous career | 0.529 | 0.220 | 0.354 | ||||||
| Yes | 20 (5.0) | 73 (18.3) | 26 (6.5) | 67 (16.8) | 19 (4.8) | 74 (18.5) | |||
| No | 57 (14.3) | 250 (62.5) | 67 (16.8) | 240 (60.0) | 50 (12.5) | 257 (64.3) | |||
| Academic Year | 0.355 | 0.953 | |||||||
| General studies (1st and 2nd year) | 22 (5.5) | 76 (19.0) | 23 (5.8) | 75 (18.8) | 17 (4.3) | 81 (20.3) | 0.977 | ||
| Faculty studies (3rd year or more) | 55 (13.8) | 247 (61.8) | 70 (17.5) | 232 (58.0) | 52 (13.0) | 250 (62.5) | |||
| Type of work | <0.001 | <0.001 | <0.001 | ||||||
| Yes, health related | 22 (5.5) | 26 (6.5) | 24 (6.0) | 24 (6.0) | 22 (5.5) | 26 (6.5) | |||
| Yes, other than health | 11 (2.8) | 104 (26.0) | 12 (3.0) | 103 (25.8) | 8 (2.0) | 107 (26.8) | |||
| Does not work | 44 (11.0) | 193 (48.3) | 57 (14.3) | 180 (45.0) | 39 (9.8) | 198 (49.5) | |||
| With whom do you live? | 0.123 | 0.004 | 0.059 | ||||||
| Accompanied | 69 (17.3) | 305 (76.2) | 81 (20.3) | 293 (73.3) | 61 (15.3) | 313 (78.3) | |||
| Alone | 8 (2.0) | 18 (4.5) | 12 (3.0) | 14 (3.5) | 8 (2.0) | 18 (4.5) | |||
| Do you have children? | 0.393 | 0.991 | 0.274 | ||||||
| Yes | 4 (1.0) | 26 (6.5) | 7 (1.8) | 23 (5.8) | 3 (0.8) | 27 (6.8) | |||
| No | 73 (18.3) | 297 (74.3) | 86 (21.5) | 284 (71.0) | 66 (16.5) | 304 (76.0) | |||
| Have you been diagnosed with COVID-19? | <0.001 | <0.001 | <0.001 | ||||||
| Yes | 42 (10.5) | 57 (14.3) | 46 (11.5) | 53 (13.3) | 39 (9.8) | 60 (15.0) | |||
| No | 35 (8.8) | 266 (66.5) | 47 (11.8) | 254 (63.5) | 30 (7.5) | 271 (67.8) | |||
| Has any family member been diagnosed with COVID-19? | <0.001 | <0.001 | 0.001 | ||||||
| Sí | 67 (16.8) | 198 (49.5) | 74 (18.5) | 191 (47.8) | 58 (14.5) | 207 (51.8) | |||
| No | 10 (2.5) | 125 (31.3) | 19 (4.8) | 116 (29.0) | 11 (2.8) | 124 (31.0) | |||
** p-values calculated with the Chi-Square test of independence.
Table 3.
Factors associated with presenting depression, anxiety, and stress in students of the Universidad Norbert Wiener. Simple regression.
Table 3.
Factors associated with presenting depression, anxiety, and stress in students of the Universidad Norbert Wiener. Simple regression.
| Characteristics | Simple Regression | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Depression | Anxiety | Stress | |||||||
| PR | 95%CI | p * | PR | 95%CI | p * | PR | 95%CI | p * | |
| Sex | |||||||||
| Male | Ref | Ref | Ref | ||||||
| Female | 0.80 | 0.73–0.88 | <0.001 | 0.79 | 0.71–0.88 | <0.001 | 0.81 | 0.75–0.88 | <0.001 |
| Age | 1.01 | 1.01–1.02 | <0.001 | 1.01 | 1.00–1.02 | 0.002 | 1.01 | 1.00–1.02 | 0.005 |
| Marital status | |||||||||
| Non united | Ref | Ref | Ref | ||||||
| United | 1.13 | 0.98–1.30 | 0.081 | 1.07 | 0.87–1.31 | 0.517 | 1.10 | 0.96–1.27 | 0.163 |
| Faculty | |||||||||
| Health sciences | Ref | Ref | Ref | ||||||
| Engineering and business | 1.15 | 1.04–1.26 | 0.004 | 1.23 | 1.11–1.37 | <0.001 | 1.15 | 1.05–1.25 | 0.001 |
| Law and political science | 1.11 | 0.94–1.32 | 0.196 | 1.20 | 1.01–1.43 | 0.037 | 1.14 | 0.99–1.32 | 0.050 |
| Previous career | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 1.03 | 0.92–1.16 | 0.546 | 1.08 | 0.94–1.24 | 0.252 | 1.05 | 0.93–1.17 | 0.384 |
| Academic Year | |||||||||
| General studies (1st and 2nd year) | Ref | Ref | Ref | ||||||
| Faculty studies (3rd year or more) | 1.05 | 0.93–1.18 | 0.382 | 1.00 | 0.88–1.13 | 0.953 | 1.00 | 0.90–1.11 | 0.977 |
| Type of work | |||||||||
| Yes, health related | Ref | Ref | Ref | ||||||
| Yes, other than health | 1.66 | 1.27–2.18 | <0.001 | 1.79 | 1.34–2.39 | <0.001 | 1.71 | 1.31–2.23 | <0.001 |
| Does not work | 1.50 | 1.15–1.96 | 0.003 | 1.51 | 1.13–2.03 | 0.005 | 1.54 | 1.18–2.01 | 0.001 |
| With whom do you live? | |||||||||
| Accompanied | Ref | Ref | Ref | ||||||
| Alone | 0.81 | 0.77–0.85 | 0.219 | 0.68 | 0.47–0.98 | 0.041 | 0.82 | 0.63–1.07 | 0.153 |
| Do you have children? | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 0.92 | 0.79–1.07 | 0.314 | 1.00 | 0.81–1.22 | 0.991 | 0.91 | 0.80–1.03 | 0.165 |
| Have you been diagnosed with COVID-19? | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 1.53 | 1.28–1.82 | <0.001 | 1.57 | 1.30–1.90 | <0.001 | 1.48 | 1.26–1.74 | <0.001 |
| Has any family member been diagnosed with COVID-19? | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 1.23 | 1.13–1.34 | <0.001 | 1.19 | 1.07–1.31 | 0.001 | 1.17 | 1.08–1.27 | <0.001 |
* p-values obtained with Generalized Linear Models (GLM), Poisson family, log-link function and robust variance.
Table 4.
Factors associated with depression, anxiety, and stress in students of the Universidad Norbert Wiener. Multiple regression.
Table 4.
Factors associated with depression, anxiety, and stress in students of the Universidad Norbert Wiener. Multiple regression.
| Characteristics | Multiple Regression ** | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Depression | Anxiety | Stress | |||||||
| PR | 95%CI | p * | PR | 95%CI | p * | PR | 95%CI | p * | |
| Sex | |||||||||
| Male | Ref | Ref | Ref | ||||||
| Female | 0.91 | 0.84–0.99 | 0.028 | 0.90 | 0.83–0.99 | 0.033 | 0.92 | 0.86–0.99 | 0.037 |
| Age | 1.03 | 1.02–1.04 | <0.001 | 1.03 | 1.01–1.05 | <0.001 | 1.02 | 1.01–1.04 | <0.001 |
| Faculty | |||||||||
| Health sciences | Ref | Ref | Ref | ||||||
| Engineering and business | 1.04 | 0.95–1.13 | 0.313 | 1.11 | 1.00–1.22 | 0.033 | 1.04 | 0.97–1.12 | 0.204 |
| Law and political science | 1.02 | 0.89–1.17 | 0.713 | 1.07 | 0.92–1.24 | 0.345 | 1.03 | 0.94–1.14 | 0.456 |
| Type of work | |||||||||
| Yes, health related | Ref | Ref | Ref | ||||||
| Yes, other than health | 1.37 | 1.07–1.78 | 0.012 | 1.39 | 1.06–1.82 | 0.017 | 1.39 | 1.08–1.78 | 0.010 |
| Does not work | 1.45 | 1.11–1.90 | 0.006 | 1.36 | 1.01–1.82 | 0.039 | 1.42 | 1.08–1.87 | 0.011 |
| With whom do you live? | |||||||||
| Accompanied | Ref | Ref | Ref | ||||||
| Alone | 0.81 | 0.77–0.85 | 0.219 | 0.73 | 0.56–0.95 | 0.020 | 0.82 | 0.63–1.07 | 0.153 |
| Have you been diagnosed with COVID-19? | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 1.20 | 1.03–1.39 | 0.017 | 1.19 | 1.01–1.40 | 0.029 | 1.20 | 1.04–1.38 | 0.010 |
| Has any family member been diagnosed with COVID-19? | |||||||||
| Yes | Ref | Ref | Ref | ||||||
| No | 1.00 | 0.93–1.08 | 0.906 | 0.93 | 0.85–1.02 | 0.149 | 0.97 | 0.90–1.04 | 0.477 |
* p-values obtained with Generalized Linear Models (GLM). ** Adjusted for age, sex, type of work and COVID-19 diagnosis.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
MDPI and ACS Style
Hernández-Yépez, P.J.; Muñoz-Pino, C.O.; Ayala-Laurel, V.; Contreras-Carmona, P.J.; Inga-Berrospi, F.; Vera-Ponce, V.J.; Failoc-Rojas, V.E.; Pereira-Victorio, C.J.; Valladares-Garrido, M.J. Factors Associated with Anxiety, Depression, and Stress in Peruvian University Students during the COVID-19 Pandemic. Int. J. Environ. Res. Public Health 2022, 19, 14591. https://doi.org/10.3390/ijerph192114591
AMA Style
Hernández-Yépez PJ, Muñoz-Pino CO, Ayala-Laurel V, Contreras-Carmona PJ, Inga-Berrospi F, Vera-Ponce VJ, Failoc-Rojas VE, Pereira-Victorio CJ, Valladares-Garrido MJ. Factors Associated with Anxiety, Depression, and Stress in Peruvian University Students during the COVID-19 Pandemic. International Journal of Environmental Research and Public Health. 2022; 19(21):14591. https://doi.org/10.3390/ijerph192114591
Chicago/Turabian StyleHernández-Yépez, Palmer J., Carlos O. Muñoz-Pino, Valeria Ayala-Laurel, Pavel J. Contreras-Carmona, Fiorella Inga-Berrospi, Víctor J. Vera-Ponce, Virgilo E. Failoc-Rojas, César Johan Pereira-Victorio, and Mario J. Valladares-Garrido. 2022. "Factors Associated with Anxiety, Depression, and Stress in Peruvian University Students during the COVID-19 Pandemic" International Journal of Environmental Research and Public Health 19, no. 21: 14591. https://doi.org/10.3390/ijerph192114591
APA StyleHernández-Yépez, P. J., Muñoz-Pino, C. O., Ayala-Laurel, V., Contreras-Carmona, P. J., Inga-Berrospi, F., Vera-Ponce, V. J., Failoc-Rojas, V. E., Pereira-Victorio, C. J., & Valladares-Garrido, M. J. (2022). Factors Associated with Anxiety, Depression, and Stress in Peruvian University Students during the COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 19(21), 14591. https://doi.org/10.3390/ijerph192114591
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
