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Gastroenterology Insights
Volume 4
Issue 1
10.4081/gi.2012.e2
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Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Helicobacter pylori Clarithromycin Resistance Assessment: Are Gastric Antral Biopsies Sufficient?

by
Vincenzo De Francesco
1,
Floriana Giorgio
1,
Enzo Ierardi
1,
Cristina D'Ercole
2,
Cesare Hassan
2 and
Angelo Zullo
2,*
1
Section of Gastroenterology, Department of Medical Sciences University of Foggia, Foggia, Italy
2
Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2012, 4(1), e2; https://doi.org/10.4081/gi.2012.e2
Submission received: 15 October 2011 / Revised: 22 February 2012 / Accepted: 22 February 2012 / Published: 5 March 2012

Abstract

Gastric biopsy ssampling could affect accuracy of Helicobacter pylori clarithromycin resistance assessment due to coexistence of susceptible and resistant strains (i.e. heteroresistance) either in same gastric site (intraniche) or in two different gastric sites (interniche). This study aimed to assess differences in the H. pylori clarithromycin resistance prevalence in relation to the gastric biopsy sampling by using Taqman-real time polymerase chain reaction (PCR). The study enrolled 137 patients. Primary clarithromycin resistance was observed in 15 isolates exclusively in antrum, in 7 cases exclusively in gastric body, and in 3 patients in both gastric sites. The overall prevalence of clarithromycin resistance was 13.1% by using exclusively antral biopsies, and 18.2% by using biopsies from both gastric sites. Moreover, intra-niche heteroresistance was observed in 19 (76%) out of 25 patients harbouring resistant strains. Our data found a heterogeneous distribution of resistant H. pylori strains in the stomach. Similarly to culture, gastric biopsies from both antrum and gastric body are needed to increase the accuracy of PCR-based methods for clarithromycin resistance assessment.
Keywords: Helicobacter pylori; clarithromycin resistance; polymerase chain reaction Helicobacter pylori; clarithromycin resistance; polymerase chain reaction

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MDPI and ACS Style

De Francesco, V.; Giorgio, F.; Ierardi, E.; D'Ercole, C.; Hassan, C.; Zullo, A. Helicobacter pylori Clarithromycin Resistance Assessment: Are Gastric Antral Biopsies Sufficient? Gastroenterol. Insights 2012, 4, e2. https://doi.org/10.4081/gi.2012.e2

AMA Style

De Francesco V, Giorgio F, Ierardi E, D'Ercole C, Hassan C, Zullo A. Helicobacter pylori Clarithromycin Resistance Assessment: Are Gastric Antral Biopsies Sufficient? Gastroenterology Insights. 2012; 4(1):e2. https://doi.org/10.4081/gi.2012.e2

Chicago/Turabian Style

De Francesco, Vincenzo, Floriana Giorgio, Enzo Ierardi, Cristina D'Ercole, Cesare Hassan, and Angelo Zullo. 2012. "Helicobacter pylori Clarithromycin Resistance Assessment: Are Gastric Antral Biopsies Sufficient?" Gastroenterology Insights 4, no. 1: e2. https://doi.org/10.4081/gi.2012.e2

APA Style

De Francesco, V., Giorgio, F., Ierardi, E., D'Ercole, C., Hassan, C., & Zullo, A. (2012). Helicobacter pylori Clarithromycin Resistance Assessment: Are Gastric Antral Biopsies Sufficient? Gastroenterology Insights, 4(1), e2. https://doi.org/10.4081/gi.2012.e2

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