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Pediatric Reports
Volume 4
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10.4081/pr.2012.e18
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Case Report

Concurrence of Thyrotoxicosis and Gitelman’s Syndrome-Associated Hypokalemia-Induced Periodic Paralysis

by
Shinsaku Imashuku
1,
Tomoko Teramura-Ikeda
1,
Naoko Kudo
1,
Shigehiro Kaneda
1 and
Toshihiro Tajima
2,*
1
Division of Pediatrics, Takasago-seibu Hospital, Takasago
2
Department of Pediatrics, Hokkaido Graduate School of Medicine, Sapporo, Japan
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2012, 4(2), e18; https://doi.org/10.4081/pr.2012.e18
Submission received: 11 September 2011 / Revised: 11 September 2011 / Accepted: 29 December 2011 / Published: 2 April 2012

Abstract

A 16-year-old Japanese boy with a history of truancy had been treated at a psychiatric clinic. When the patient was referred to us for hypokalemia-associated paralysis, the diagnosis of thyrotoxic hypokalemic periodic paralysis was made, common in Asian men. Subsequently, the patient was found to have persistently high plasma renin and aldosterone levels. Thus, solute carrier family 12 member 3 gene (SLC12A3) analysis was performed. A novel missense homozygous mutation CTC->CAC at codon 858 (L858H) was found for which the patient was homozygous and his non-consanguineous parents heterozygote. These findings indicated that the patient developed hypokalemia-associated paralysis concurrently with thyrotoxicosis and Gitelman’s syndrome. This case underscores the importance of careful examinations of adolescents with complaints of truancy as well as of precise determinations of the causes of hypokalemia-associated paralysis.
Keywords: hypokalemic periodic paralysis; thyrotoxicosis; Gitelman’s syndrome; adolescents; truancy hypokalemic periodic paralysis; thyrotoxicosis; Gitelman’s syndrome; adolescents; truancy

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MDPI and ACS Style

Imashuku, S.; Teramura-Ikeda, T.; Kudo, N.; Kaneda, S.; Tajima, T. Concurrence of Thyrotoxicosis and Gitelman’s Syndrome-Associated Hypokalemia-Induced Periodic Paralysis. Pediatr. Rep. 2012, 4, e18. https://doi.org/10.4081/pr.2012.e18

AMA Style

Imashuku S, Teramura-Ikeda T, Kudo N, Kaneda S, Tajima T. Concurrence of Thyrotoxicosis and Gitelman’s Syndrome-Associated Hypokalemia-Induced Periodic Paralysis. Pediatric Reports. 2012; 4(2):e18. https://doi.org/10.4081/pr.2012.e18

Chicago/Turabian Style

Imashuku, Shinsaku, Tomoko Teramura-Ikeda, Naoko Kudo, Shigehiro Kaneda, and Toshihiro Tajima. 2012. "Concurrence of Thyrotoxicosis and Gitelman’s Syndrome-Associated Hypokalemia-Induced Periodic Paralysis" Pediatric Reports 4, no. 2: e18. https://doi.org/10.4081/pr.2012.e18

APA Style

Imashuku, S., Teramura-Ikeda, T., Kudo, N., Kaneda, S., & Tajima, T. (2012). Concurrence of Thyrotoxicosis and Gitelman’s Syndrome-Associated Hypokalemia-Induced Periodic Paralysis. Pediatric Reports, 4(2), e18. https://doi.org/10.4081/pr.2012.e18

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