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Clinics and Practice
Volume 10
Issue 3
10.4081/cp.2020.1265
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Extensive Catastrophic Thromboses from Elevation of Factor VIII

by
Jacqueline Kropf
1,
Sarah Cheyney
1,
Josselin Vachon
1,
Philip Flaherty
2,
Mai Vo
2 and
Steve J. Carlan
3,*
1
Department of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA
2
Division of Critical Care Medicine, Orlando Regional Healthcare, Orlando, FL, USA
3
Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USA
*
Author to whom correspondence should be addressed.
Clin. Pract. 2020, 10(3), 1265; https://doi.org/10.4081/cp.2020.1265
Submission received: 12 May 2020 / Revised: 14 August 2020 / Accepted: 25 August 2020 / Published: 4 September 2020

Abstract

Catastrophic thrombotic syndrome, otherwise known as thrombotic storm (TS) is an extreme prothrombotic clinical syndrome that presents as rapid onset of multiple thromboembolic events affecting a large variety of vasculature. In recent studies, there has been a correlation of high plasma levels of factor VIII with thrombotic events. We present the case of a young man who exhibited multi-organ failure due to thrombotic storm. A 38-year-old male presented to the emergency department for progressive dyspnea and was diagnosed to have pulmonary embolism. The patient developed respiratory distress requiring intubation and was diagnosed with both an ST-elevation myocardial infarction and right cerebral infarction during the hospital course. The patient expired and autopsy revealed the cause of death to be myocardial, cerebral and renal infarction from widespread vascular thrombosis. Autopsy revealed cause of death to be elevated factor VIII associated thrombotic coagulopathy. Factor VIII level upon autopsy was 375% (55-200%). Although TS is rare, it can be lifethreatening if not recognized early. Survival depends on the prompt initiation and duration of anticoagulation.
Keywords: catastrophic thrombosis; factor VIII; arterial thrombosis; venous thrombosis; pulmonary embolus catastrophic thrombosis; factor VIII; arterial thrombosis; venous thrombosis; pulmonary embolus

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MDPI and ACS Style

Kropf, J.; Cheyney, S.; Vachon, J.; Flaherty, P.; Vo, M.; Carlan, S.J. Extensive Catastrophic Thromboses from Elevation of Factor VIII. Clin. Pract. 2020, 10, 1265. https://doi.org/10.4081/cp.2020.1265

AMA Style

Kropf J, Cheyney S, Vachon J, Flaherty P, Vo M, Carlan SJ. Extensive Catastrophic Thromboses from Elevation of Factor VIII. Clinics and Practice. 2020; 10(3):1265. https://doi.org/10.4081/cp.2020.1265

Chicago/Turabian Style

Kropf, Jacqueline, Sarah Cheyney, Josselin Vachon, Philip Flaherty, Mai Vo, and Steve J. Carlan. 2020. "Extensive Catastrophic Thromboses from Elevation of Factor VIII" Clinics and Practice 10, no. 3: 1265. https://doi.org/10.4081/cp.2020.1265

APA Style

Kropf, J., Cheyney, S., Vachon, J., Flaherty, P., Vo, M., & Carlan, S. J. (2020). Extensive Catastrophic Thromboses from Elevation of Factor VIII. Clinics and Practice, 10(3), 1265. https://doi.org/10.4081/cp.2020.1265

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