Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats
Abstract
:1. Introduction
2. Results
2.1. Mechanical and Cold Allodynia Induced by Oxaliplatin Administration in Rats
2.2. Melittin Alleviates Oxaliplatin Induced Mechanical and Cold Allodynia
2.3. Mellitin Inhibits Oxaliplatin-Induced Hyperexcitated Spinal WDR Neuronal Activity
2.4. Both Spinal α1- and 2- Adrenergic Receptors are Involved in the Analgesic Effects of Melittin
3. Discussion
4. Conclusion
5. Materials and Methods
5.1. Animals
5.2. Oxaliplatin Administration
5.3. Behavioral Tests
5.4. Melittin Administration
5.5. In vivo Extracellular Recording
5.6. Antagonist Treatment
5.7. Statistics
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Choi, S.; Chae, H.K.; Heo, H.; Hahm, D.-H.; Kim, W.; Kim, S.K. Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats. Toxins 2019, 11, 396. https://doi.org/10.3390/toxins11070396
Choi S, Chae HK, Heo H, Hahm D-H, Kim W, Kim SK. Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats. Toxins. 2019; 11(7):396. https://doi.org/10.3390/toxins11070396
Chicago/Turabian StyleChoi, Seunghwan, Hyeon Kyeong Chae, Ho Heo, Dae-Hyun Hahm, Woojin Kim, and Sun Kwang Kim. 2019. "Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats" Toxins 11, no. 7: 396. https://doi.org/10.3390/toxins11070396
APA StyleChoi, S., Chae, H. K., Heo, H., Hahm, D. -H., Kim, W., & Kim, S. K. (2019). Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats. Toxins, 11(7), 396. https://doi.org/10.3390/toxins11070396