Ochratoxin A Contamination of Food from Croatia
Abstract
:1. Introduction
2. OTA Food Contamination
2.1. Wheat
2.2. Maize
2.3. Beans
2.4. Grapes and Wine
Commoditiy | Sampling year | Sampling region | Sample no. positive | Mean SD | Range | References |
---|---|---|---|---|---|---|
Ochratoxin A (μg/kg) a | ||||||
Maize | 1972–1976 | EN | 45/542 | - 1 | - 1 | [19] |
1996 | EN | 4/45 | 0.7 2,3 | 0.36–1.1 | [21] | |
non-EN | 6/60 | 62.7 2,3 | 0.36–223.6 | [21] | ||
1997 | EN Slavonski Brod | 25/50 | 73.4 2,3 | 0.29–613.7 | [21] | |
non-EN | 11/56 | 20.2 2,3 | 0.26–216.6 | [21] | ||
1999 | EN Slavonski Brod | 9/11 | 20.0 ± 14.8 | 0.02–40.0 | [20] | |
non-EN Osijek | - 1 | 0.8 ± 1.3 | 0.02–4.0 | [20] | ||
non-EN Istria | - 1 | 0.4 ± 0.8 | 0.02–1.6 | [20] | ||
non-EN Hrvatsko Zagorje | - 1 | 0.4 ± 0.4 | 0.02–2.0 | [20] | ||
2002 | non-EN | 19/49 | 1.47 ± 0.38 3 | - 1 | [22,23] | |
Wheat | 1999 | EN Slavonski Brod | 33/33 | 38.7 ± 27.1 | 2.0–160.0 | [20] |
non-EN Osijek | 24/27 b | 8.7 ± 8.2 | 0.02–32.0 | [20] | ||
non-EN Istria | - 1 | 1.3 ± 2.6 | 0.02–6.4 | [20] | ||
non-EN Hrvatsko Zagorje | - 1 | 2.1 ± 1.5 | 0.02–4.8 | [20] | ||
1972–1976 | EN | 11/130 | - 1 | 5–140 | [19] | |
Beans | 2001 | non-EN | 17/45 | 0.41 ± 0.21 3 | 0.25–0.92 | [25] |
Red wine | 2002–2003 | non-EN | 7/7 | 22 ± 11 | 12–47 | [28] |
White wine | 2002–2003 | non-EN | 4/7 | 10 ± 9 | 15–22 | [28] |
Red wine | 2007 | non-EN | 6/6 | - 1 | 19–50 | [29] |
White wine | 2007 | non-EN | 8/10 | - 1 | 2–21 | [29] |
3. Conclusions
Acknowledgements
References
- Speijers, G.J.A.; Van Egmond, H.P. Worldwide ochratoxin A levels in food and feeds. In Human Ochratoxicosis and Its Pathologies; Creppy, E.E., Castegnaro, M., Dirheimer, G., Eds.; Colloque INSERM/John Libbey Eurotext: Montrouge, France, 1993; pp. 85–100. [Google Scholar]
- Duarte, S.C.; Pena, A.; Lino, C.M. Ochratoxin A non-conventional exposure sources–A review. Microchem. J. 2009, 93, 115–120. [Google Scholar]
- Barlow, S.; Bolger, P.M.; Pitt, J.I.; Verger, P. Ochratoxin A. In Safety Evaluation of Certain Food Additives and Contaminants; World Health Organization Food Additives Series: Geneva, Switzerland, 2008; Volume 59, pp. 357–429. [Google Scholar]
- Verger, P.; Volatier, J.L.; Dufour, A. Estimation des niveaux théoriques d’ingestion d’aflatoxines et d’ochratoxine. In Les mycotoxines dans l’alimentation: Evaluation et gestion du risque; Pfohl-Leszkowicz, A., Ed.; TEC & DOC Lavoisier: Paris, France, 1999; pp. 371–384. [Google Scholar]
- Visconti, A.; Pascale, M.; Centonze, G. Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high-performance liquid chromatography. J. Chromatogr. A 1999, 864, 89–101. [Google Scholar]
- Miletić-Medved, M.; Domijan, A.-M.; Peraica, M. Recent data on endemic nephropathy and related urothelial tumors in Croatia. Wien. Klin. Wochenschr. 2005, 117, 604–609. [Google Scholar]
- Peraica, M.; Domijan, A.-M.; Miletić-Medved, M.; Fuchs, R. The involvement of mycotoxins in the development of endemic nephropathy. Wiener. Klin. Wochenschr. 2008, 120, 402–407. [Google Scholar]
- Krogh, P. Mycotoxin porcine nephropathy: a possible model for Balkan endemic nephropathy. In Endemic Nephropathy; Puchlev, A., Ed.; Bulgarian Academy of Science: Sofia, Bulgaria, 1974; pp. 266–270. [Google Scholar]
- Pfohl-Leszkowicz, A.; Manderville, R.A. Ochatoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol. Nutr. Food Res. 2007, 51, 61–99. [Google Scholar]
- Hult, K.; Pleština, R.; Habazin-Novak, V.; Radić, B.; Čeović, S. Ochratoxina A in human blood and Balkan endemic nephropathy. Arch. Toxicol. 1982, 51, 313–321. [Google Scholar] [CrossRef]
- Petkova-Bocharova, T.; Chernozemsky, I.N.; Castegnaro, M. Ochratoxin A in human blood in relation to Balkan endemic nephropathy system tumours in Bulgaria. Food Addit. Contam. 1988, 5, 299–301. [Google Scholar]
- Radić, B.; Fuchs, R.; Peraica, M.; Lucić, A. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicol. Lett. 1997, 91, 105–109. [Google Scholar]
- Peraica, M.; Domijan, A.-M.; Fuchs, R.; Lucić, A.; Radić, B. The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol. Lett. 1999, 110, 105–112. [Google Scholar]
- Domijan, A.-M.; Želježić, D.; Kopjar, N.; Peraica, M. Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B1-treated rats. Toxicology 2006, 222, 53–59. [Google Scholar] [PubMed]
- Manderville, R.A.; Pfohl-Leszkowicz, A. Bioactivation and DNA adduction as a rationale for ochratoxin A carciongenesis. World Mycotoxin J. 2008, 1, 357–367. [Google Scholar]
- Pfohl-Leszkowicz, A. Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial cancers. Arh. Hig. Rada Toksikol. 2009, 60, 465–483. [Google Scholar]
- Speijers, G.J.A.; Speijers, M.H.M. Combined toxic effects of mycotoxins. Toxicol. Lett. 2004, 153, 91–98. [Google Scholar]
- Pfohl-Leszkowicz, A.; Moliné, A.; Tozlovanu, A.; Manderville, R.A. Combined toxic effects of ochratoxin A and citrinin, in vitro and in vivo. In Food Contaminants: Mycotoxins and Food Allergen; Siantar, D.P., Trucksess, M.W., Scott, P.M., Herman, E.M., Eds.; ACS Symposium series: Washington, DC, USA, 2008; Volume 1001, pp. 56–80. [Google Scholar]
- Pavlović, M.; Pleština, R.; Krogh, P. Ochratoxin A contamination of foodstuffs in an area with Balkan (endemic) nephropathy. Acta Path. Microbiol. Scand. Sect. B 1979, 87, 243–246. [Google Scholar]
- Puntarić, D.; Bošnir, J.; Šmit, Z.; Škes, I.; Baklaić, Ž. Ochratoxin A in corn and wheat: geographical association with endemic nephropathy. Croat. Med. J. 2001, 42, 175–180. [Google Scholar] [PubMed]
- Jurjević, Ž.; Solfrizzo, M.; Cvjetković, B.; Avantaggiato, G.; Visconti, A. Ochratoxin A and fumonisins (B1 and B2) in maize from Balkan nephropathy endemic and non endemic areas of Croatia. Mycotoxin Res. 1999, 15, 67–80. [Google Scholar]
- Domijan, A.-M.; Peraica, M.; Jurjević, Ž.; Ivić, D.; Cvjetković, B. Fumonisin B1, fumonisin B2, zearalenone and ochratoxin A contamination of maize in Croatia. Food Addit. Contam. 2005, 22, 677–680. [Google Scholar] [CrossRef] [PubMed]
- Domijan, A-M.; Peraica, M.; Cvjetković, B.; Turčin, S.; Jurjević, Ž.; Ivić, D. Mould contamination and co-occurrence of mycotoxins in maize grain in Croatia. Acta Pharm. 2005, 55, 349–356. [Google Scholar] [PubMed]
- Pleština, R.; Čeović, S.; Gatenbeck, S.; Habazin-Novak, V.; Hult, K.; Hokby, E.; Krogh, P.; Radić, B. Human exposure to ochratoxin A in areas of Yugoslavia with endemic nephropathy. J. Environ. Pathol. Toxicol. Oncol. 1990, 10, 145–148. [Google Scholar] [PubMed]
- Domijan, A.-M.; Peraica, M.; Žlender, V.; Cvjetković, B.; Jurjević, Ž.; Topolovec-Pintarić, S.; Ivić, D. Seed-borne fungi and ochratoxin A contamination of dry beans (Phaseolus vulgaris L.) in the Republic of Croatia. Food Chem. Toxicol. 2005, 43, 427–432. [Google Scholar] [CrossRef] [PubMed]
- Ottender, H.; Majerus, P. Occurrence of ochratoxin A (OTA) in wines: influence of the type of wine and its geographical origin. Food Addit. Contam. 2000, 17, 793–798. [Google Scholar]
- Zimmerli, B.; Dick, R. Ochratoxin A in table wine and grape-juice: occurrence and risk assessment. Food Addit. Contam. 1996, 13, 655–668. [Google Scholar]
- Domijan, A.-M.; Peraica, M. Ochratoxin A in wine. Arh. Hig. Rada Toksikol. 2005, 56, 17–20. [Google Scholar]
- Flajs, D.; Domijan, A.-M.; Ivić, D.; Cvjetković, B.; Peraica, M. ELISA and HPLC analysis of ochratoxin A in red wines of Croatia. Food Control 2009, 20, 590–592. [Google Scholar]
- Peraica, M.; Domijan, A.-M.; Matašin, M.; Lucić, A.; Radić, B.; Delaš, F.; Horvat, M.; Bosanac, I.; Balija, M.; Grgičević, D. Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities. Arch. Toxicol. 2001, 75, 410–414. [Google Scholar]
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Peraica, M.; Flajs, D.; Domijan, A.-M.; Ivić, D.; Cvjetković, B. Ochratoxin A Contamination of Food from Croatia. Toxins 2010, 2, 2098-2105. https://doi.org/10.3390/toxins2082098
Peraica M, Flajs D, Domijan A-M, Ivić D, Cvjetković B. Ochratoxin A Contamination of Food from Croatia. Toxins. 2010; 2(8):2098-2105. https://doi.org/10.3390/toxins2082098
Chicago/Turabian StylePeraica, Maja, Dubravka Flajs, Ana-Marija Domijan, Dario Ivić, and Bogdan Cvjetković. 2010. "Ochratoxin A Contamination of Food from Croatia" Toxins 2, no. 8: 2098-2105. https://doi.org/10.3390/toxins2082098
APA StylePeraica, M., Flajs, D., Domijan, A. -M., Ivić, D., & Cvjetković, B. (2010). Ochratoxin A Contamination of Food from Croatia. Toxins, 2(8), 2098-2105. https://doi.org/10.3390/toxins2082098