Next Article in Journal
Transmissive Mode Laser Micro-Ablation Performance of Ammonium Dinitramide-Based Liquid Propellant for Laser Micro-Thruster
Next Article in Special Issue
Effect of Gold Nanoparticle Radiosensitization on DNA Damage Using a Quartz Tuning Fork Sensor
Previous Article in Journal
Holographic Fabrication of 3D Moiré Photonic Crystals Using Circularly Polarized Laser Beams and a Spatial Light Modulator
Previous Article in Special Issue
Toward the Real-Time and Rapid Quantification of Bacterial Cells Utilizing a Quartz Tuning Fork Sensor
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Micromachines
Volume 14
Issue 6
10.3390/mi14061218
Review Report
micromachines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

A Hemodynamic Pulse Wave Simulator Designed for Calibration of Local Pulse Wave Velocities Measurement for Cuffless Techniques

Micromachines 2023, 14(6), 1218; https://doi.org/10.3390/mi14061218
by Cheng-Yan Guo 1,†, Jau-Woei Perng 2,†, Li-Ching Chen 3 and Tung-Li Hsieh 4,*,†
Reviewer 1:
S. I. Shchukin
Reviewer 2: Anonymous
Micromachines 2023, 14(6), 1218; https://doi.org/10.3390/mi14061218
Submission received: 2 May 2023 / Revised: 18 May 2023 / Accepted: 8 June 2023 / Published: 9 June 2023
(This article belongs to the Special Issue MEMS and Piezoelectric Sensors for Biomedical Applications)

Round 1

Reviewer 1 Report

Please, look the attachement.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This manuscript reported a method to develop a pulse wave simulator capable of simulating the human cardiovascular system in vitro including complex hemodynamic phenomena. The authors also aimed to design a cuffless BPM for local PTT measurement and discussed the simulated pulse waves generated in this research. Nonetheless, more explains are also needed to strengthen authors' statements before accepting the manuscript for publication.

1. The formation of arterial pressure is influenced by various factors, including blood filling, cardiac ejection, and the elastic properties of large arteries. In this paper, the pulse wave simulator primarily focuses on simulating blood pressure and does not provide sufficient data support for the elastic characteristics of the silicone hose.

2. The pressure values of the simulated pulse wave depicted range from 115 mmHg to 145 mmHg (Figure 4), which is higher than the typical blood pressure range of 60 mmHg to 120 mmHg in normal individuals. The specific reason and significance behind this discrepancy are not thoroughly explained in the paper. 

3. Normal heart regulation involves both contraction and relaxation, resulting in a pulse waveform that typically consists of two distinct peaks. However, in the simulated waveform presented in the study, only a single peak is observed. Whether the obtained results can be effectively used to construct a calibration model. Further investigation and analysis are required to determine the reasons behind the missing second peak and to explore potential solutions for improving the simulation accuracy.

4. What do the numbers on the abscissa in Figure 9 represent?

-

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop