Next Article in Journal
ALBI Score Is a Strong Predictor of Toxicity Following SIRT for Hepatocellular Carcinoma
Next Article in Special Issue
Survival Impact of Chronic Obstructive Pulmonary Disease or Acute Exacerbation on Patients with Rectal Adenocarcinoma Undergoing Curative Resection: A Propensity Score-Matched, Population-Based Cohort Study
Previous Article in Journal
Fluorescence Image-Guided Surgery for Thyroid Cancer: Utility for Preventing Hypoparathyroidism
Previous Article in Special Issue
Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 13
Issue 15
10.3390/cancers13153793
Review Report
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Osteopontin as a Regulator of Colorectal Cancer Progression and Its Clinical Applications

Cancers 2021, 13(15), 3793; https://doi.org/10.3390/cancers13153793
by Katyana Amilca-Seba 1,2,3, Michèle Sabbah 1,2,3,4, Annette K. Larsen 1,2,3,4 and Jérôme A. Denis 1,2,3,5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cancers 2021, 13(15), 3793; https://doi.org/10.3390/cancers13153793
Submission received: 16 June 2021 / Revised: 21 July 2021 / Accepted: 22 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue New Insights into Colorectal Cancer)

Round 1

Reviewer 1 Report

In this study, Amilca-Seba et al. summarize the functional roles of osteopontin (OPN) in colorectal cancer (CRC). This review is well-organized covering most of topics that readers possibly want to know. The authors describe from regulation and expression of OPN and then discuss the roles of OPN in CRC. This review also covers the potentials of OPN as a biomarker. This is an excellent review and I have only a few minor comments for this manuscript: (1) It would be great and easier to understand if there are associated pathways/genes/proteins shown in Figure 2 (e.g., Snail for EMT and VEGF for angiogenesis); (2) The authors mention the potentials of OPN as a biomarker, but how about the potentials as a therapeutic target? Anti-OPN antibodies or small molecules inhibiting OPN? Enhancing regulation against OPN expression by overexpression of genes or miRNAs? Difficulties or limitations in current therapeutic approaches targeting OPN?

Author Response

We thank the reviewer for the careful review of our manuscript on the regulation and roles of osteopontin in the progression of colorectal cancer. We appreciate the positive comments and useful suggestions. We have now modified figure 2 in order to associate the signaling pathways, genes and functions of osteopontin. In addition, we have added a small paragraph concerning the potential role of osteopontin as a therapeutic target. We hope the manuscript is now ready for publication and thank you again for your time and effort.

Reviewer 2 Report

The review describes the molecular mechanisms of action of the multifunctional protein Osteopontin (OPN) and focus on its association with colorectal cancer progression and metastasis and on its potential use as a clinical biomarker.

The review is well articulated, all major fuction of OPN are clearly described and documented with a rich and updated bibliography.

Author Response

We thank you for taking the time to review our manuscript regarding the regulation and role of osteopontin in the progression of colorectal cancer.

We are delighted that you enjoyed our manuscript and we hope this will also be true for the readers of « Cancers ». Thanks again.

 

Back to TopTop