Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. MCC-UPs Exhibited Better Overall Survival in Comparison to the Virus-Negative KP Group. MCPyV-Negative UPs with High Intratumoral CD8+ and Foxp3+ Infiltrate Exhibited Better Overall Survival
2.2. Virus-Positive and Virus-Negative MCC-UPs Exhibited an Immunoprofile Similar to Virus-Positive and Virus-Negative Cutaneous MCCs, Respectively
2.3. Virus-Positive and Virus-Negative MCC-UPs Exhibited Tumoral Immune Expression Similar to or Higher Than That of Virus-Positive MCC-KPs
2.4. Virus-Positive and Virus-Negative MCC-UPs Exhibited Molecular Alterations Similar to Virus-Positive and Virus-Negative Primary Cutaneous MCCs, Respectively
3. Discussion
4. Materials and Methods
4.1. Immunohistochemistry
4.2. Molecular Analyses
4.3. Statistical Analyses
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Donizy, P.; Wróblewska, J.P.; Dias-Santagata, D.; Woznica, K.; Biecek, P.; Mochel, M.C.; Wu, C.-L.; Kopczynski, J.; Pieniazek, M.; Ryś, J.; et al. Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles. Cancers 2021, 13, 1621. https://doi.org/10.3390/cancers13071621
Donizy P, Wróblewska JP, Dias-Santagata D, Woznica K, Biecek P, Mochel MC, Wu C-L, Kopczynski J, Pieniazek M, Ryś J, et al. Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles. Cancers. 2021; 13(7):1621. https://doi.org/10.3390/cancers13071621
Chicago/Turabian StyleDonizy, Piotr, Joanna P. Wróblewska, Dora Dias-Santagata, Katarzyna Woznica, Przemyslaw Biecek, Mark C. Mochel, Cheng-Lin Wu, Janusz Kopczynski, Malgorzata Pieniazek, Janusz Ryś, and et al. 2021. "Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles" Cancers 13, no. 7: 1621. https://doi.org/10.3390/cancers13071621
APA StyleDonizy, P., Wróblewska, J. P., Dias-Santagata, D., Woznica, K., Biecek, P., Mochel, M. C., Wu, C. -L., Kopczynski, J., Pieniazek, M., Ryś, J., Marszalek, A., & Hoang, M. P. (2021). Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles. Cancers, 13(7), 1621. https://doi.org/10.3390/cancers13071621