DHODH Inhibition Exerts Synergistic Therapeutic Effect with Cisplatin to Induce Ferroptosis in Cervical Cancer through Regulating mTOR Pathway
Round 1
Reviewer 1 Report
Dear authors,
Congratulations on your very interesting paper. The manuscript will make an impact in the field.
1. The manuscript could benefit from a more conventional writing for a larger audience.
2. In the abstract, please remove the headlines of the sections.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Reviewer 2 Report
•This is a very meaningful research. • DHODH inhibition and DDP have synergistic anti-tumor effects, and this significance is closely related to iron death and mTOR pathway •Question 1. The use of HPV vaccine and the screening of intraepithelial neoplasia have been widely carried out in economically developed regions of China. In economically underdeveloped regions of the world, cervical cancer is an important cause of serious threats to women‘s health. Therefore, China in LINE39、 42 should be changed to developing countries and regions •Question 2. Line 350 (in inclusion,.....): The inference of mTOR mechanism should be elaborated in the discussion.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf