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Cancers
Volume 15
Issue 24
10.3390/cancers15245883
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Review
Peer-Review Record

Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management

Cancers 2023, 15(24), 5883; https://doi.org/10.3390/cancers15245883
by Eric S. Adams 1, Sriram Deivasigamani 1,*, Mahdi Mottaghi 2, Jiaoti Huang 3, Rajan T. Gupta 1,4 and Thomas J. Polascik 1,2,4
Reviewer 1:
Filippo Alongi
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Cancers 2023, 15(24), 5883; https://doi.org/10.3390/cancers15245883
Submission received: 10 November 2023 / Revised: 14 December 2023 / Accepted: 14 December 2023 / Published: 18 December 2023
(This article belongs to the Special Issue Salvage Therapy for Recurrent Prostate Cancer—Optimizing Oncological and Functional Outcomes)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is a well-written review of an emerging issue. Other papers faced this topic but the present one seems to be really interesting and updated.

 

I strongly suggest to add some sentences evalutating the even more modern possibility to re-irradiate these patients (future perspective) including these papers:

Archer P, et al. Salvage Stereotactic Reirradiation for Local Recurrence in the Prostatic Bed After Prostatectomy: A Retrospective Multicenter Study. Eur Urol Oncol. 2023 doi: 10.1016/j.euo.2023.03.005.

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

Introduction:

"Multiple local salvage therapies are available for patients 52 with radiorecurrent PCa including salvage radical prostatectomy (sRP), salvage ablative 53 therapies (including cryoablation and high-intensity focused ultrasound (HIFU), and repeat RT with brachytherapy or EBRT.": in order to give an improved context, I would suggest to cite some recent literature about reirradiation and non surgical local treatments in this field. To improve the background section, I would suggest to refer to PMID: 37728816

Author Response

Please see the attachment

Thanks 

Author Response File: Author Response.docx

Reviewer 3 Report

Comments and Suggestions for Authors

I want to congratulate the authors for their rigorous, well-executed, and structured review work. However, I consider that the inclusion in it of a table that shows the different criteria to evaluate the progression criteria such as Zumsteg's and the other existing ones would facilitate the understanding of the text. I consider that the same could be done with the existing alternatives for selecting the technique for prostate biopsy. I believe these tables will enrich your work.

Author Response

Please see the attachment.

Thanks 

Author Response File: Author Response.docx

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