Next Article in Journal
HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma
Next Article in Special Issue
Quantitative Optical Redox Imaging of Melanoma Xenografts with Different Metastatic Potentials
Previous Article in Journal
Proguanil Suppresses Breast Tumor Growth In Vitro and In Vivo by Inducing Apoptosis via Mitochondrial Dysfunction
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 16
Issue 5
10.3390/cancers16050873
Review Report
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Ex Vivo Fluorescence Confocal Microscopy of MRI-Guided Targeted Prostate Biopsies for Rapid Detection of Clinically Significant Carcinomas—A Feasibility Study

Cancers 2024, 16(5), 873; https://doi.org/10.3390/cancers16050873
by Ulf Titze 1,*, Barbara Titze 1, Torsten Hansen 1,2, Peter J. Barth 3, Furat Abd Ali 4, Fried Schneider 4, Matthias Benndorf 5 and Karl-Dietrich Sievert 4
Reviewer 1:
Wenchi Chen
Reviewer 2: Anonymous
Cancers 2024, 16(5), 873; https://doi.org/10.3390/cancers16050873
Submission received: 30 January 2024 / Revised: 19 February 2024 / Accepted: 19 February 2024 / Published: 22 February 2024
(This article belongs to the Special Issue Application of Fluorescence Imaging in Cancer)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This manuscript entitled “Ex Vivo Fluorescence Confocal Microscopy of MRI-guided targeted prostate biopsies for rapid detection of clinically significant carcinomas - a feasibility study” appears well-written. They reported an ex vivo fluorescence confocal microscopy examined specimen immediately from target biopsy. The result was good in sensitivity and excellent in specificity. Therefore, this method can be used for the assisting diagnosis of prostate cancer during MRI-fusion biopsy. It also can be used for helping focal therapy.

There is some spelling problem in the line 398, 399 and 400 such as fre-quently, al-lowed, etc.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The author explored the utilization of microscopy technique which without the loss of patient biopsy material revealed pretty good diagnosis of prostate cancer that require treatment. Overall, it it’s a great study that will help in reducing diagnostic time, reduction in stress and will help in proper intervention by patients for their life style/psycho-therapy decisions. Some improvements are required in manuscript as below:

 

1.     Define PSA where it comes first in the manuscript.

2.     Define Prostate Imaging Reporting & Data System (PI-RADS) in introduction and its implications in terms of grades etc.

3.     Rename Figure4 as Figure1 everywhere.

4.     Section 2.5 on “Intraoperative FCM analysis of the target biopsies as a triage test” need to be expanded to include what are the features that are collected by FCM. What algorithm is used to make decision on the tumor state with what cut-offs/parameters?

5.     Line 272: : says “with 50%”: 50% of what? Please mention it.

6.     Discussion section has lots of words with “-“ in them. Please remove them. For example: al-lowed ; detec-tion ; fre-quently ; re-mains ;  intermedi-ate-risk ; addition-al ; partic-ularly ; char-acterize ; epithe-lia ; conven-tional ; depend-ing ; re-quiring ; cur-rently

 

Comments on the Quality of English Language

Lots of words with "-", they need to be removed.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop