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Crystals
Volume 15
Issue 2
10.3390/cryst15020140
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity

by
Laurentiu Pricop
1,
Ioana Cristina Marincas
2,
Anamaria Hanganu
1,
Mihaela Ganciarov
3,
Augustin M. Mădălan
1 and
Maria Olimpia Miclăuș
4,*
1
Department of Inorganic Chemistry, Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90–92 Panduri St., 050663 Bucharest, Romania
2
The Earth, Environmental and Life Sciences Division, The Research Institute of the University of Bucharest (ICUB), 050095 Bucharest, Romania
3
Analysis Team, National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, Splaiul Independentei No. 202, Sector 6, 060021 Bucharest, Romania
4
National Institute for R&D of Isotopic and Molecular Technologies, Donat 67-103, 5, 700, 400293 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Crystals 2025, 15(2), 140; https://doi.org/10.3390/cryst15020140
Submission received: 19 December 2024 / Revised: 23 January 2025 / Accepted: 24 January 2025 / Published: 27 January 2025
(This article belongs to the Special Issue Structural Studies in Drug Discovery and Development: From the Lead to the Pharmaceutical Form, 2nd Edition)
Versions Notes

Abstract

Three complexes of Cd(II), [Cd(NA)₂(NO₃)₂(H₂O)₂] (1), [Cd(NA)₂(NO₃)₂(H₂O)₂]·2NA (2), and [Cd(ox)(NA)(H₂O)]·H₂O (3) (NA = nicotinamide, ox = oxalate) were synthesized and characterized. Complexes (1) and (2) are mononuclear, while complex (3) is a bidimensional polymeric coordination compound, with oxalate anions bridging metal ions in two different ways: µ₂ bis-bidentate chelating manner and µ₄ bis-bidentate bis-monodentate manner. The stereochemistry of Cd(II) in compounds (1) and (3) is a distorted pentagonal bipyramid, while in compound (2) it is a regular octahedron. Complexes (1) and (2) demonstrated significant activity against Enterococcus faecalis and Escherichia coli, showcasing their potential as effective antibacterial agents and inhibitors of microbial adhesion. The complexes were characterized by means of single-crystal X-ray diffraction, elemental analysis, FTIR (all complexes), 1H NMR, 13C NMR, fluorescence spectroscopy, and antimicrobial activity (complexes (1) and (2)).
Keywords: Cd(II) complexes; nicotinamide; pentagonal bipyramid geometry; hydrogen bonds Cd(II) complexes; nicotinamide; pentagonal bipyramid geometry; hydrogen bonds

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MDPI and ACS Style

Pricop, L.; Marincas, I.C.; Hanganu, A.; Ganciarov, M.; Mădălan, A.M.; Miclăuș, M.O. Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity. Crystals 2025, 15, 140. https://doi.org/10.3390/cryst15020140

AMA Style

Pricop L, Marincas IC, Hanganu A, Ganciarov M, Mădălan AM, Miclăuș MO. Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity. Crystals. 2025; 15(2):140. https://doi.org/10.3390/cryst15020140

Chicago/Turabian Style

Pricop, Laurentiu, Ioana Cristina Marincas, Anamaria Hanganu, Mihaela Ganciarov, Augustin M. Mădălan, and Maria Olimpia Miclăuș. 2025. "Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity" Crystals 15, no. 2: 140. https://doi.org/10.3390/cryst15020140

APA Style

Pricop, L., Marincas, I. C., Hanganu, A., Ganciarov, M., Mădălan, A. M., & Miclăuș, M. O. (2025). Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity. Crystals, 15(2), 140. https://doi.org/10.3390/cryst15020140

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