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Article

Influence of Particulate Matter on Asthma Control in Adult Asthma

by
Chalerm Liwsrisakun
,
Warawut Chaiwong
,
Chaiwat Bumroongkit
,
Athavudh Deesomchok
,
Theerakorn Theerakittikul
,
Atikun Limsukon
,
Konlawij Trongtrakul
,
Pattraporn Tajarernmuang
,
Nutchanok Niyatiwatchanchai
and
Chaicharn Pothirat
*
Division of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Atmosphere 2023, 14(2), 410; https://doi.org/10.3390/atmos14020410
Submission received: 21 December 2022 / Revised: 14 February 2023 / Accepted: 19 February 2023 / Published: 20 February 2023
(This article belongs to the Special Issue Outdoor Air Pollution and Human Health (2nd Edition))
Browse Figure
Versions Notes

Abstract

:
No clear evidence shows the association between particulate matter (PM) with an aerodynamic diameter < 10 µm (PM10) and asthma control. Therefore, the objective of this study was to determine the association between PM10 and asthma control. A retrospective observational study was conducted at the Airway Clinic, Chiang Mai University Hospital, Chiang Mai, Thailand, between January 2010 and April 2013. Various values of asthma control test (ACT) scores between high and low PM10 periods were analyzed. The association of an increased monthly average PM10 level and ACT score was analyzed using a time series analysis. There were a total of 1180 visits from 236 asthmatic patients. The monthly average ACT score was significantly lower in the high PM10 period compared with the low PM10 period. Every 10 µg/m3 increment of monthly average PM10 resulted in a significantly decreased ACT score at lag zero and one month, with an adjusted coefficient of –0.101 (95% CI; –0.165, –0.037), p-value = 0.002 and –0.079 (95% CI; –0.147, –0.012), p-value = 0.021, respectively. Monthly average PM10 significantly affected asthma control in asthmatic patients. During the air pollution period, the serial assessments of ACT should be measured for early detection of worsening asthma control.

1. Introduction

Air pollution is one of the major problems in the northern part of Thailand, including Chiang Mai. Every year, air pollutant levels usually exceed the world health organization (WHO) safety threshold during pre-summer and summer seasons (January–April) in this region. The main sources of air pollutants in this area come from forest fires and the burning of post-harvesting agricultural residues [1]. The Pollution Control Department of Thailand reported that the particulate matter with a diameter less than 10 microns (PM10) reached a peak concentration in mid-March 2010, at 383 micrograms per cubic meter (μg/m3) [2]. Although the policy on controlling air pollution has been published by the Thai government since 1992, air pollution remains a serious problem in this region of Thailand annually [3].
Previous studies concluded that the exposure to daily air pollution ((PM10, particulate matter with a diameter less than 2.5 microns (PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3)) and meteorological parameters were associated with asthma health [4,5]. However, the particular matter levels which usually exceed the WHO safety threshold are the main problem in Chiang Mai, Thailand [1]. Therefore, we focused on the association between PM10 and asthma control in this study.
Previous studies reported the negative short-term effect of air pollution exposure, both PM10 and PM2.5, and health effects, including all-cause, cardiovascular, respiratory, and cerebrovascular mortality [6,7,8,9,10,11]. For chronic airway disease, air pollution was associated with occurrence of asthma, acute asthma, and chronic obstructive pulmonary disease (COPD) exacerbation [12,13,14,15,16]. Pothirat et al. also found that short-term exposure to PM10 resulted in a short-term negative impact on the quality of life (QoL) in subjects with COPD [17]. In asthma patients, previous studies also demonstrated that exposure to PM10 caused a significant impact on symptoms, quality of life, extra hospital visits, and hospitalization due to asthma, as well as asthma control defined by the 2006–2009 Global Initiative for Asthma (GINA) guidelines [14,18,19].
According to GINA guidelines, the achievement and maintenance of asthma control is the goal of asthma care [20]. The Asthma Control Test (ACT) is a useful and popular tool for assessing asthma control [21]. The ACT questionnaire is designed for the self-assessment of asthma symptoms and perception of control [21]. This questionnaire consists of five questions, including daytime and nighttime asthma symptoms, the use of rescue medications used, the limitation of activity due to asthma, and the patient’s perception of asthma control [21]. The Thai version of ACT has been validated and extensively used in many clinical settings [22]. However, data on the association between ACT scores and PM10 are still limited and controversial. A study reported a statistically insignificant trend of a decreased ACT score in association with an increase in PM10 in 32 asthmatic patients [20]. They found that 10 μg/m3 of PM10 exposure was associated with a decrease in ACT score, with a coefficient of –0.022 (95% CI; –0.045, 0.001; p value = 0.060) [23]. Another study, published by Fernandez et al., also showed no correlation between ACT scores among 99 asthmatic patients and PM10 levels during a four-month study period [24]. More studies on the effect of PM10 on asthma control using ACT scores are still required. Therefore, the objective of this study was to determine the association between PM10 and asthma control using the ACT questionnaire in adults with asthma.

2. Materials and Methods

2.1. Study Design and Population

This retrospective observational study was conducted on asthmatic patients greater than 18 years old treated at the Airway Clinic, Chiang Mai University Hospital, Chiang Mai, Thailand, between January 2010 and April 2013. All included subjects lived in Chiang Mai for at least one year. All subjects were diagnosed with asthma on the basis of GINA guidelines [20]. Subjects with a history of asthma exacerbations or hospitalizations for lower respiratory tract infections within the past four weeks were excluded. Subjects with other coexisting pulmonary diseases, five or more pack-years of smoking history, or pregnancy were also excluded. This study protocol was approved by the Research Ethics Committee of the Faculty of Medicine, Chiang Mai University (Institutional Review Board (IRB) approval number: MED-2565-09244, date of approval: 28 October 2022).

2.2. Asthma Control Test (ACT)

The Thai version of the ACT questionnaire [22] was routinely serially measured during each visit (one to three months) in all subjects throughout the study period. The five-item ACT questionnaire is designed for the self-assessment of asthma symptoms and perception of control [21]. This questionnaire consists of five questions, including asthma symptoms (daytime and nocturnal), the use of rescue medications, the limitation of activity due to asthma, and the patient’s perception of asthma control. Each item of ACT includes five degrees of responses ranging from one to five [21]. A higher score means better asthma control, where the summation score yields a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma) [21].The monthly average of ACT scores of all subjects (each item and total score) was used for the analysis.

2.3. Air Pollution Data and Meteorological Parameters

The levels of air pollutants, including PM10, carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3), were measured at sampling stations of the Pollution Control Department, Ministry of National Resources and Environment located in municipal areas of the Muang Chiang Mai District, Chiang Mai Province, Thailand [2]. The pollution data were reported as a monthly average. The cut-off of the high and low monthly averages of PM10 in this study was based on the average 24 h PM10 level of 45 µg/m3 published in the 2021 Air Quality Guidelines of the WHO [25]. The meteorological data, including pressure, temperature, humidity, rain, sun, and wind speed, were obtained from the Northern Meteorology Center, Chiang Mai Province. A sampling monitoring station of meteorological data was also located in the municipal area of Muang Chiang Mai District, Chiang Mai, Thailand.

2.4. Statistical Analysis

Results for numerical values were expressed as means ± standard deviation (SD) or median and IQR (interquartile range), and those for categorical data were expressed as absolute frequencies and percentages. Various values of pollutant data, meteorological data, and ACT scores between high and low PM10 periods were determined using independent sample t-tests. The correlations between the monthly average of all pollutants and all meteorological parameters and ACT were determined using Pearson’s correlation coefficient analysis. The following cut-off parameters were used in this study: 0 < |r| < 0.3 = weak correlation; 0.3 < |r|< 0.7 = moderate correlation; and |r| > 0.7 = strong correlation [26]. The association between the monthly average of each item and the total score of ACT and a monthly average of PM10 concentrations was analyzed using general linear models (GLM) after adjustment for SO2, NO2, CO, O3, and all meteorological parameters. Adjustments for SO2, NO2, CO, O3, and all meteorological parameters were performed in the GLM using a multivariable linear regression. The associations between the monthly average concentrations of PM10 and changes in ACT score were examined for each lag from zero to five months by using time series analysis. GLM was used to fit the time series data. Lag time zero (lag0) is the month of an increase in monthly average PM10. Results were displayed as adjusted coefficients, with 95% confidence intervals (CI). All tests were two-tailed, and p-values below 0.05 were considered statistically significant. Statistical analysis was performed using a software package (StataCorp version 16, College Station, TX, USA).

3. Results

There were a total of 1180 visits from 236 asthmatic patients from January 2010 to April 2013. The monthly averages of all pollutants data and meteorological parameters are shown in Table 1. All pollutant data between the high PM10 period (≥45 µg/m3) and the low PM10 periods (<45 µg/m3) are shown in Table 2. During the study period, there were 15 and 25 months of high and low PM10, respectively. The PM10 concentration in the high PM10 months was significantly higher compared with the low PM10 months (73.6 ± 23.9 µg/m3 vs. 27.4 ± 8.3 µg/m3, p < 0.001, respectively). The monthly average concentrations of other pollutants were also significantly higher in the high PM10 months. Additional data are shown in Table 2.
Correlations between the monthly average of weather data, including pollutants and meteorological parameters and the monthly average of ACT score, are shown in Table 3. There were significant correlations between the monthly average of all pollutants and the ACT score. The monthly average of all meteorological parameters was also significantly correlated with a monthly average of ACT scores, except for temperature and wind speed. Among all the air pollutants, PM10 was demonstrated to have the strongest negative correlation, with a monthly average of ACT score, r = –0.70, p < 0.001. Additional data are shown in Table 3.
The monthly average scores of each item and the total score of ACT were significantly lower in the high PM10 period when compared with the low PM10 period. The monthly average of total ACT scores in the high PM10 period and the low PM10 period were 21.49 ± 0.48 and 22.14 ± 0.49, p < 0.001, respectively. The differences in the monthly average of each item score of ACT between the months of high PM10 versus low PM10 are also shown in Table 4.
Variations of the monthly average PM10 and the monthly average of total ACT scores throughout the study period are shown in Figure 1. After adjustment for the other pollutants (CO, SO2, NO2, and O3) and all meteorological data, we found an association between PM10 and asthma control. The total score of ACT and all of the items, except for the shortness of breath item, significantly decreased in correlation with an increase of every 10 µg/m3 of PM10. The effect of every 10 µg/m3 increment of PM10 on the decrement of total ACT score was significant, with an adjusted coefficient of –0.101 (95% CI; –0.165, –0.037), p-value = 0.002. Additional data are shown in Table 5.
The associations of every 10 µg/m3 increase in the monthly average of PM10 on the monthly average of ACT score are displayed in Table 6. After adjustment for the other pollutants and all meteorological data, the monthly average ACT score decreased significantly at lag zero and one month, with an adjusted coefficient of –0.101 (95% CI; –0.165, –0.037), p-value = 0.002 and –0.079 (95% CI; –0.147, –0.012), p-value = 0.021, respectively. Additional data are shown in Table 6.

4. Discussion

For more than ten years, air pollution has been a major problem in Northern Thailand, including Chiang Mai, due to the mass burning of agricultural waste and forest fires in the dry season during January through April [1]. Our study found that the monthly average of each item and total score of ACT were significantly lower in the high PM10 period when compared with the low PM10 period. Moreover, we found a significant effect of every 10 µg/m3 increase in PM10 on the reduction of the total ACT and sub-elements of ACT scores, except for the shortness of breath item. For time series analysis, we also found that the monthly average ACT score decreased significantly at lag zero and one month.
Previous evidence suggested the negative effect of PM10 exposure and health effects, including cardiovascular, respiratory, cerebrovascular, and all-cause mortality [6,7,8,9,10,11]. In Northern Thailand, we found associations between increased concentrations of daily PM10, with daily non-accidental mortality and causes of death, including COPD, coronary artery disease (CAD), and sepsis [10]. In chronic airway disease, PM10 was associated with acute asthma and COPD exacerbation [12,13,14,15]. We also found that every 10 μg/m3 increase in PM10 concentration increased the risk of asthma and COPD exacerbations with a lag time of six to seven days (adjusted relative risk (RR) ranged from 1.02 to 1.03) [13]. Moreover, we demonstrated that short-term exposure to PM10 harmed QoL in patients with COPD [17]. In asthma subjects, previous studies showed that PM10 affected patients’ quality of life and asthma control [14,18,19]. Ścibor et al. [19] revealed the effect of an increased exposure to PM10 on reduced scores in QoL measured by the Asthma Quality of Life Questionnaire (AQLQ). Another study by Maestrelli et al. [23] demonstrated a trend of poor QoL measured by St. George’s Respiratory Questionnaire (SGRQ) in association with exposure to PM10 (coefficient = 0.22; 95% CI; –0.005, 4.451; p = 0.055).
For the association between PM10 and asthma control, Jacquemin et al., using the 2006–2009 GINA criteria, found that living in areas with high PM10 increased the risks of uncontrolled asthma, with the OR of 1.50 (95% CI; 1.19, 1.89) [18]. Another study, although its result was not statistically significant, displayed a tendency of poorer asthma control by lower ACT scores in asthmatic patients exposed to high PM10 (coefficient = –0.022; 95% CI, –0.045, 0.001; p = 0.060) [23]. However, this study included only 32 asthmatic subjects. Furthermore, the relatively short-term study in 99 asthmatic patients by Fernandez et al. [24] also showed no association between PM10 and ACT score. The non-correlation result of this study might be due to the non-significant difference in the monthly average of PM10 during the four months of the two-year study period (27.6 ± 5.3 vs. 25.8 ± 9.5) [24]. Thus, the influence of air pollution, particularly PM10, on asthma control is still unclear. Our study focused on the association between PM10 levels during 40 consecutive months and asthma control measured by ACT in adult asthmatic patients living only in Chiang Mai province. Our result supported the effect of PM10 on asthma control by showing that the monthly average ACT score decreased significantly at lag zero and one month, with an adjusted coefficient of –0.101 (95% CI; –0.165, –0.037), p-value = 0.002 and –0.079 (95% CI; –0.147, –0.012), p-value = 0.021, respectively. Additionally, we demonstrated that four out of five items of the ACT questionnaire, including the nighttime symptoms, numbers of rescuers used, limitation of activity, and self-rating of asthma control were significantly influenced by PM10. Our findings were consistent with the previous study indicating that symptoms and limitation of activity were the most affected domains of the quality of life in asthma subjects [19].
To the best of our knowledge, this is the first time series analysis on the effect of PM10 on asthma control. Our previous study showed that every 10 μg/m3 increment in PM10 concentration increased the risk of asthma exacerbations within one week [13]. However, after exposure to air pollution, some patients might present with worsening asthma control instead of exacerbation. Therefore, our study showed more evidence, other than asthma exacerbation, that PM10 had more deteriorating effects on nighttime symptoms, numbers of rescuer use, limitation of activity, and self-rating of asthma control. In addition, we also demonstrated the immediate and delayed effects of PM10 which affected asthma control not only during the month of high PM10 exposure but also one month later.
Achievement and maintenance of asthma control is the goal of asthma care [20], and ACT is an easy and useful tool for assessing asthma control [21]. A subjective self-assessment of patients suffering from asthma, including asthma symptoms (daytime and nocturnal), the use of rescue medications, the asthma-related limitation of activity, and the patient’s perception of asthma control has a great benefit in the long-term evaluation of disease control. The significant difference in ACT scores during the high and low PM10 period confirmed that this tool was beneficial in the demonstration of worsening asthma control during high pollution season.
The major strength of our study was the inclusion of asthma patients who were treated by pulmonologists at a special asthma clinic of the university hospital. In addition to ACT assessment and spirometry, our clinic routinely checks the inhalation technique, treatment adherence, patients’ comorbidities, and non-respiratory medications. In addition, we provide patient education for long-term asthma care focused on individualized patient environment control, including avoidance of exposure to specific aeroallergens, extreme climate change, and air pollution avoidance. A few studies showed that asthma management by specialists, rather than general practitioners, resulted in fewer symptoms, more appropriate use of asthma controllers, fewer emergency room visits, and better quality of life [27,28]. Thus, the effects of inappropriate management by physicians were likely to be minimal in our study. The factors which affected asthma control would be the disease factor itself. Another strength of our study was the duration of the data collection. We collected the air pollution data of Chiang Mai province for 40 months, which can be divided into the high and the low PM10 period according to the daily WHO threshold of 45 μg/m3. In addition, we included only the asthma patients who lived in Chiang Mai for at least one year, which was long enough to expose them to both low and high PM10 periods. This might be the reason why the results of our study on the correlation between PM10 and ACT score was different from the previous negative studies. However, our study had some limitations. Firstly, although the inclusion of patients treated by asthma specialists was considered to be the strength of this study, as mentioned above, in other ways our results might not be generally applicable to asthmatic patients treated by internists or general practitioners in real-world practice. As mentioned above, outcomes of asthma management by specialists proved to be better than outcomes by generalists. Consequently, the effects of air pollution on asthma control in patients not treated by the experts were expected to be more obvious. Further studies to discover the effects of air pollution on asthma control in general practice are required. Secondly, the evidence of pollution-induced airway inflammation demonstrated by fractional exhaled nitric oxide (FeNO) was not measured in this study. Previous studies showed some associations between FeNO and air pollution in asthma [23,29]. Future studies focusing on the effects of air pollution on inflammatory biomarkers in association with outcomes of asthma, including asthma control, should be performed. Thirdly, because our clinic provided education for the protection of air pollution to our patients, we did not collect data on personal protection against air pollution, including the use of an N-95 mask and home air purifier, which might account for confounding factors in this study. Therefore, these factors should be included for analysis in future studies.

5. Conclusions

Every 10 µg/m3 increase in monthly average PM10 resulted in a reduction in the ACT score. PM10 had a significantly negative impact on asthma control in asthmatic patients. In the period of air pollution, assessment of asthma control by ACT should be serially measured for early detection of worsening of asthma control before progression to asthma exacerbation. A worldwide policy for tighter control of air pollution is needed to reduce the impact of air pollutants on people’s health, especially asthma subjects.

Author Contributions

Study conception and design, C.L., C.P. and W.C.; data acquisition, C.P. and W.C; data analysis, C.P. and W.C.; investigation, C.L., C.P., W.C., C.B., A.D., T.T., A.L., K.T., P.T. and N.N.; resources, C.P. and W.C.; data curation, C.L., C.P. and W.C.; writing—original draft preparation, C.L. and W.C.; writing—review and editing, C.L., C.P. and W.C.; visualization, C.L. and C.P.; supervision, C.L. and C.P.; project administration, C.L., W.C. and C.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was approved by the Research Ethics Committee of the Faculty of Medicine, Chiang Mai University (Institutional Review Board (IRB) approval number: MED-2565-09244, date of approval: 28 October 2022).

Informed Consent Statement

Not applicable.

Data Availability Statement

The data that support the findings of this study are available on request from the corresponding author.

Acknowledgments

The authors wish to acknowledge the contribution of the staff of the Division of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University to this study. The authors would like to thank Ruth Leatherman, Research Administration Section, Faculty of Medicine, Chiang Mai University for native English proofreading.

Conflicts of Interest

The authors declare no conflict of interest.

Abbreviations

PM10, particulate matters with diameter of less than 10 microns; PM2.5, particulate matters with diameter of less than 2.5 microns; CO, carbon monoxide; SO2, sulfur dioxide; NO2, nitrogen dioxide; O3, ozone.

References

  1. Pengchai, P.; Chantara, S.; Sopajaree, K.; Wangkarn, S.; Tengcharoenkul, U.; Rayanakorn, M. Seasonal variation, risk assessment and source estimation of PM 10 and PM10-bound PAHs in the ambient air of Chiang Mai and Lamphun, Thailand. Environ.Monit. Assess. 2009, 154, 197–218. [Google Scholar] [CrossRef] [PubMed]
  2. Air Quality and Noise Management Bureau, 2004. Pollution Control Department, Ministry of National Resources and Envi-ronment Homepage. Available online: http://www.pcd.go.th/info (accessed on 10 April 2022).
  3. Bumroongkit, C.; Liwsrisakun, C.; Deesomchok, A.; Pothirat, C.; Theerakittikul, T.; Limsukon, A.; Trongtrakul, K.; Tajarernmuang, P.; Niyatiwatchanchai, N.; Euathrongchit, J.; et al. Correlation of Air Pollution and Prevalence of Acute Pulmonary Embolism in Northern Thailand. Int. J. Environ. Res. Public. Health 2022, 19, 12808. [Google Scholar] [CrossRef] [PubMed]
  4. Poole, J.A.; Barnes, C.S.; Demain, J.G.; Bernstein, J.A.; Padukudru, M.A.; Sheehan, W.J.; Fogelbach, G.G.; Wedner, J.; Codina, R.; Levetin, E.; et al. Impact of weather and climate change with indoor and outdoor air quality in asthma: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee. J. Allergy. Clin. Immunol. 2019, 143, 1702–1710. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  5. Zheng, X.Y.; Orellano, P.; Lin, H.L.; Jiang, M.; Guan, W.J. Short-term exposure to ozone, nitrogen dioxide, and sulphur dioxide and emergency department visits and hospital admissions due to asthma: A systematic review and meta-analysis. Environ. Int. 2021, 150, 106435. [Google Scholar] [CrossRef]
  6. Orellano, P.; Reynoso, J.; Quaranta, N.; Bardach, A.; Ciapponi, A. Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis. Environ. Int. 2020, 142, 105876. [Google Scholar] [CrossRef]
  7. Pun, V.C.; Kazemiparkouhi, F.; Manjourides, J.; Suh, H.H. Long-Term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults. Am. J. Epidemiol. 2017, 186, 961–969. [Google Scholar] [CrossRef] [Green Version]
  8. Huang, F.; Pan, B.; Wu, J.; Chen, E.; Chen, L. Relationship between exposure to PM2.5 and lung cancer incidence and mortality: A meta-analysis. Oncotarget 2017, 8, 43322–43331. [Google Scholar] [CrossRef] [Green Version]
  9. Pothirat, C.; Chaiwong, W.; Liwsrisakun, C.; Bumroongkit, C.; Deesomchok, A.; Theerakittikul, T.; Limsukon, A.; Tajarernmuang, P.; Phetsuk, N. Acute effects of air pollutants on daily mortality and hospitalizations due to cardiovascular and respiratory diseases. J. Thorac. Dis. 2019, 11, 3070–3083. [Google Scholar] [CrossRef]
  10. Pothirat, C.; Chaiwong, W.; Liwsrisakun, C.; Bumroongkit, C.; Deesomchok, A.; Theerakittikul, T.; Limsukon, A.; Tajarernmuang, P.; Phetsuk, N. The short-term associations of particular matters on non-accidental mortality and causes of death in Chiang Mai, Thailand: A time series analysis study between 2016-2018. Int. J. Environ. Health Res. 2021, 31, 538–547. [Google Scholar] [CrossRef]
  11. Liu, Y.; Pan, J.; Zhang, H.; Shi, C.; Li, G.; Peng, Z.; Ma, J.; Zhou, Y.; Zhang, L. Short-Term Exposure to Ambient Air Pollution and Asthma Mortality. Am. J. Respir. Crit. Care. Med. 2019, 200, 24–32. [Google Scholar] [CrossRef] [Green Version]
  12. Guarnieri, M.; Balmes, J.R. Outdoor air pollution and asthma. Lancet 2014, 383, 1581–1592. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Pothirat, C.; Tosukhowong, A.; Chaiwong, W.; Liwsrisakun, C.; Inchai, J. Effects of seasonal smog on asthma and COPD exacerbations requiring emergency visits in Chiang Mai, Thailand. Asian. Pac. J. Allergy. Immunol. 2016, 34, 284–289. [Google Scholar] [PubMed]
  14. Meng, Y.Y.; Rull, R.P.; Wilhelm, M.; Lombardi, C.; Balmes, J.; Ritz, B. Outdoor air pollution and uncontrolled asthma in the San Joaquin Valley, California. J. Epidemiol. Community. Health 2010, 64, 142–147. [Google Scholar] [CrossRef] [PubMed]
  15. Song, D.J.; Choi, S.H.; Song, W.J.; Park, K.H.; Jee, Y.K.; Cho, S.H.; Lim, D.H. The Effects of Short-Term and Very Short-Term Particulate Matter Exposure on Asthma-Related Hospital Visits: National Health Insurance Data. Yonsei. Med. J. 2019, 60, 952–959. [Google Scholar] [CrossRef]
  16. Trnjar, K.; Pintarić, S.; Mornar Jelavić, M.; Nesek, V.; Ostojić, J.; Pleština, S.; Šikić, A.; Pintarić, H. Correlation Between Occurrence and Deterioration of Respiratory Diseases and Air Pollution Within the Legally Permissible Limits. Acta. Clin. Croat. 2017, 56, 210–217. [Google Scholar] [CrossRef]
  17. Pothirat, C.; Chaiwong, W.; Liwsrisakun, C.; Bumroongkit, C.; Deesomchok, A.; Theerakittikul, T.; Limsukon, A.; Tajaroenmuang, P.; Phetsuk, N. Influence of Particulate Matter during Seasonal Smog on Quality of Life and Lung Function in Patients with Chronic Obstructive Pulmonary Disease. Int. J. Environ. Res. Public. Health 2019, 16, 106. [Google Scholar] [CrossRef] [Green Version]
  18. Jacquemin, B.; Kauffmann, F.; Pin, I.; Le Moual, N.; Bousquet, J.; Gormand, F.; Just, J.; Nadif, R.; Pison, C.; Vervloet, D.; et al. Air pollution and asthma control in the Epidemiological study on the Genetics and Environment of Asthma. J. Epidemiol. Community. Health 2012, 66, 796–802. [Google Scholar] [CrossRef] [Green Version]
  19. Ścibor, M.; Malinowska-Cieślik, M. The association of exposure to PM10 with the quality of life in adult asthma patients. Int. J. Occup. Med. Environ. Health 2020, 33, 311–324. [Google Scholar] [CrossRef]
  20. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2020. Available online: http://www.ginasthma.org (accessed on 13 December 2020).
  21. Nathan, R.A.; Sorkness, C.A.; Kosinski, M.; Schatz, M.; Li, J.T.; Marcus, P.; Murray, J.J.; Pendergraft, T.B. Development of the asthma control test: A survey for assessing asthma control. J. Allergy. Clin. Immunol. 2004, 113, 59–65. [Google Scholar] [CrossRef]
  22. Niyatiwatchanchai, N.; Chaiwong, W.; Pothirat, C. The validity and reliability of the Thai version of the asthma control test. Asian. Pac. J. Allergy. Immunol. 2021; Epub ahead of print. [Google Scholar] [CrossRef]
  23. Maestrelli, P.; Canova, C.; Scapellato, M.L.; Visentin, A.; Tessari, R.; Bartolucci, G.B.; Simonato, L.; Lotti, M. Personal exposure to particulate matter is associated with worse health perception in adult asthma. J. Investig. Allergol. Clin. Immunol. 2011, 21, 120–128. [Google Scholar]
  24. Fernandez, R.; Ariza, M.; Iscar, M.; Martinez, C.; Rubinos, G.; Gagatek, S.; Montoliu, M.A.; Casan, P. Impact of environmental air pollutants on disease control in asmathic patients. Lung. 2015, 193, 195–198. [Google Scholar] [CrossRef] [PubMed]
  25. WHO Global Air Quality Guidelines: Particulate Matter (PM2.5 and PM10), Ozone, Nitrogen Dioxide, Sulfur Dioxide and Carbon Monoxide. Executive Summary. Available online: https://apps.who.int/iris/handle/10665/345329 (accessed on 10 April 2022).
  26. Ratner, B. The correlation coefficient: Its values range between +1/−1, or do they? J. Target. Meas. Anal. Mark. 2009, 17, 139–142. [Google Scholar] [CrossRef] [Green Version]
  27. Zeiger, R.S.; Heller, S.; Mellon, M.H.; Wald, J.; Falkoff, R.; Schatz, M. Facilitated referral to asthma specialist reduces relapses in asthma emergency room visits. J. Allergy. Clin. Immunol. 1991, 87, 1160–1168. [Google Scholar] [CrossRef] [PubMed]
  28. Vollmer, W.M.; O’Hollaren, M.; Ettinger, K.M.; Stibolt, T.; Wilkins, J.; Buist, A.S.; Linton, K.L.; Osborne, M.L. Specialty differences in the management of asthma. A cross-sectional assessment of allergists’ patients and generalists’ patients in a large HMO. Arch. Intern. Med. 1997, 157, 1201–1208. [Google Scholar] [CrossRef] [PubMed]
  29. Ji, N.; Fang, M.; Baptista, A.; Cepeda, C.; Greenberg, M.; Mincey, I.C.; Ohman-Strickland, P.; Haynes, F.; Fiedler, N.; Kipen, H.M.; et al. Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma. Environ. Health 2021, 20, 12. [Google Scholar] [CrossRef] [PubMed]
Atmosphere 14 00410 g001 550
Figure 1. Variation of Monthly Average PM10 and Monthly Average of ACT Scores Throughout the Study Period. (Abbreviations: ACT, Asthma Control Test; PM10, particulate matters with diameter less than 10 microns).
Figure 1. Variation of Monthly Average PM10 and Monthly Average of ACT Scores Throughout the Study Period. (Abbreviations: ACT, Asthma Control Test; PM10, particulate matters with diameter less than 10 microns).
Atmosphere 14 00410 g001
Table
Table 1. Monthly Average of All Pollutants Data and Meteorological Parameters (from January 2010 to April 2013).
Table 1. Monthly Average of All Pollutants Data and Meteorological Parameters (from January 2010 to April 2013).
PollutantsMean ± SDMin–Max
Pollutant data
PM10 (µg/m3)44.7 ± 27.617.7–119.4
SO2 (ppb)0.9 ± 0.50.0–2.0
NO2 (ppb)10.9 ± 4.36–22
CO (ppb)0.5 ± 0.20.2–0.9
O3 (ppb)24.2 ± 10.18–47
Meteorological parameters
Pressure (millibars)1009.3 ± 3.01004.3–1014.9
Temperature (Celsius)26.9 ± 2.322.8–31.6
Humidity (%)70.1 ± 9.647.8–83.0
Rain (millimeters)3.1 ± 3.60–15.2
Sun (hours)6.9 ± 1.93.4–9.8
Wind speed (kilometer/hour)21.6 ± 4.712.5–31.5
Note: Data are mean ± SD and range.
Table
Table 2. Pollutant Data between High PM10 Period (≥45 µg/m3) and Low PM10 Periods (<45 µg/m3) Recommended by WHO Air Quality Guidelines 2021.
Table 2. Pollutant Data between High PM10 Period (≥45 µg/m3) and Low PM10 Periods (<45 µg/m3) Recommended by WHO Air Quality Guidelines 2021.
PollutantsHigh PM10
(n = 15 Months)		Low PM10
(n = 25 Months)		p-Value
Pollutants
PM10 (µg/m3) 73.6 ± 23.927.4 ± 8.3<0.001
SO2 (ppb)1.2 ± 0.40.7 ± 0.50.005
NO2 (ppb)15.1 ± 3.68.3 ± 2.1<0.001
CO (ppm)0.7 ± 0.20.4 ± 0.1<0.001
O3 (ppb)32.5 ± 9.219.2 ± 6.9<0.001
Meteorological parameters
Pressure (millibars)1010.5 ± 2.21008.8 ± 3.20.099
Temperature (Celsius)26.8 ± 2.926.9 ± 1.90.887
Humidity (%)59.5 ± 7.675.2 ± 5.4<0.001
Rain (millimeters)0.7 ± 1.14.3 ± 3.80.003
Sun (hours)8.5 ± 1.26.1 ± 1.8<0.001
Wind speed (kilometer/hour)21.7 ± 3.721.5 ± 5.10.897
Note: Data are mean ± standard deviation (SD).
Table
Table 3. Correlation between Weather Data (Pollutants and Meteorological parameters) and Asthma Control Test (ACT) Score.
Table 3. Correlation between Weather Data (Pollutants and Meteorological parameters) and Asthma Control Test (ACT) Score.
Weather DataCorrelation (r)p-Value
Pollutants
Average PM10 (ug/m3)–0.70<0.001
Average SO2 (ppb)–0.310.048
Average NO2 (ppb)–0.54<0.001
Average CO (ppm)–0.58<0.001
Average O3 (ppb)–0.480.002
Meteorological parameters
Average pressure (millibars)–0.370.025
Average temperature (Celsius)0.190.251
Average humidity (%)0.490.002
Average rainfall (millimeters)0.370.024
Average sunshine (hours)–0.440.007
Average wind speed (kilometer/hour)0.020.926
Table
Table 4. Monthly Average of Asthma Control Test (ACT) Score in High PM10 Periods (≥45 µg/m3) and Low PM10 Periods (<45 µg/m3).
Table 4. Monthly Average of Asthma Control Test (ACT) Score in High PM10 Periods (≥45 µg/m3) and Low PM10 Periods (<45 µg/m3).
ACT ScoreHigh PM10
(15 Months)		Low PM10
(25 Months)		p-Value
Question 1, limited activity (5)4.78 ± 0.094.87 ± 0.080.004
Question 2, shortness of breath (5)4.26 ± 0.114.34 ± 0.130.049
Question 3, nighttime symptom (5)4.42 ± 0.154.59 ± 0.12<0.001
Question 4, rescuer used (5)4.15 ± 0.154.32 ± 0.160.002
Question 5, self-rating of asthma control (5)3.89 ± 0.094.00 ± 0.110.002
Total score (25)21.49 ± 0.4822.14 ± 0.49<0.001
Note: Data are mean ± standard deviation (SD).
Table
Table 5. Associations between Every 10 µg/m3 Increase in Monthly Average of PM10 and Monthly Average of Total Asthma Control Test (ACT) Score and Sub-domains.
Table 5. Associations between Every 10 µg/m3 Increase in Monthly Average of PM10 and Monthly Average of Total Asthma Control Test (ACT) Score and Sub-domains.
ACT ScoreAdjusted Coefficient *95% CIp-Value
Question 1, limited activity–0.019–0.029, –0.009<0.001
Question 2, shortness of breath–0.012–0.028, 0.0040.137
Question 3, nighttime symptom–0.024–0.041, –0.0070.005
Question 4, rescuer used–0.030–0.050, –0.0090.004
Question 5, self-rating of asthma control–0.016–0.027, –0.0040.008
Total score –0.101–0.165, –0.0370.002
Note: *, adjusted for other pollutants (CO, SO2, NO2, and O3) and meteorological parameters.
Table
Table 6. Associations between Every 10 µg/m3 Increase in Monthly Average of PM10 and Monthly Average Asthma Control Test (ACT) Scores.
Table 6. Associations between Every 10 µg/m3 Increase in Monthly Average of PM10 and Monthly Average Asthma Control Test (ACT) Scores.
ACT ScoreAdjusted Coefficient *95% CIp-Value
Lag 0 month–0.101–0.165, –0.0370.002
Lag 1 month–0.079–0.147, –0.0120.021
Lag 2 months–0.026–0.098, 0.0460.481
Lag 3 months–0.012–0.085, 0.0620.759
Lag 4 months0.010–0.061, 0.0810.780
Lag 5 months0.018–0.054, 0.0890.628
Note: *, adjusted for other pollutants (CO, SO2, NO2, and O3) and meteorological parameters.
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Liwsrisakun, C.; Chaiwong, W.; Bumroongkit, C.; Deesomchok, A.; Theerakittikul, T.; Limsukon, A.; Trongtrakul, K.; Tajarernmuang, P.; Niyatiwatchanchai, N.; Pothirat, C. Influence of Particulate Matter on Asthma Control in Adult Asthma. Atmosphere 2023, 14, 410. https://doi.org/10.3390/atmos14020410

AMA Style

Liwsrisakun C, Chaiwong W, Bumroongkit C, Deesomchok A, Theerakittikul T, Limsukon A, Trongtrakul K, Tajarernmuang P, Niyatiwatchanchai N, Pothirat C. Influence of Particulate Matter on Asthma Control in Adult Asthma. Atmosphere. 2023; 14(2):410. https://doi.org/10.3390/atmos14020410

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Liwsrisakun, Chalerm, Warawut Chaiwong, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Konlawij Trongtrakul, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, and Chaicharn Pothirat. 2023. "Influence of Particulate Matter on Asthma Control in Adult Asthma" Atmosphere 14, no. 2: 410. https://doi.org/10.3390/atmos14020410

APA Style

Liwsrisakun, C., Chaiwong, W., Bumroongkit, C., Deesomchok, A., Theerakittikul, T., Limsukon, A., Trongtrakul, K., Tajarernmuang, P., Niyatiwatchanchai, N., & Pothirat, C. (2023). Influence of Particulate Matter on Asthma Control in Adult Asthma. Atmosphere, 14(2), 410. https://doi.org/10.3390/atmos14020410

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