Peer-Review Record
Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas
Diagnostics 2021, 11(4), 681; https://doi.org/10.3390/diagnostics11040681
by
Jotaro On 1
, Manabu Natsumeda 1,*, Jun Watanabe 1, Shoji Saito 1, Yu Kanemaru 1, Hideaki Abe 1, Yoshihiro Tsukamoto 1, Masayasu Okada 1, Makoto Oishi 1, Junichi Yoshimura 1, Akiyoshi Kakita 2 and Yukihiko Fujii 1
, Manabu Natsumeda 1,*, Jun Watanabe 1, Shoji Saito 1, Yu Kanemaru 1, Hideaki Abe 1, Yoshihiro Tsukamoto 1, Masayasu Okada 1, Makoto Oishi 1, Junichi Yoshimura 1, Akiyoshi Kakita 2 and Yukihiko Fujii 1Reviewer 1:
Anonymous
Reviewer 2:
Anonymous
Diagnostics 2021, 11(4), 681; https://doi.org/10.3390/diagnostics11040681
Submission received: 2 March 2021
/
Accepted: 4 April 2021
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Published: 9 April 2021
(This article belongs to the Special Issue Advances in Pediatric Neuro-Oncology)
Round 1
Reviewer 1 Report
The idea of cerebrospinal fluid biopsy of malignant brain tumors instead of invasive stereotactic procedures is very good. It opens the possibility of oncology therapy without an open biopsy. It is definitely more reliable to take CSF from cerebral ventricles. Congratulations on your excellent scientific work.
Reviewer 2 Report
This is a clearly written article that points out the need of a deeper investigation in the field and I am accepting the manuscript in its present form despite of the small sample size, since the authors stated that limitation twice throughout the manuscript.
